Properties, toxicity and current applications of the biolarvicide spinosad

Santos, Vanessa Santana Vieira; Pereira, Boscolli Barbosa

doi:10.1080/10937404.2019.1689878

Cited by 36 publications

(21 citation statements)

References 79 publications

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“…Compared with the CMR on day 0, the CMR 24 on day 1 for the three formulations dropped sharply, while the corresponding decline in the values of CMR 48 was relatively moderate (Figures and S2). Spinosad was able to control the pest through both stomach-poisoning and touch-killing approaches by affecting the nicotinic acetylcholine receptors of their nervous system. , Meanwhile, it had good penetration capacity in the cabbage leaves. Due to volatilization, photolysism, and penetration of the formulation, the amount of exposed spinosad on the leaf surface on day 1 was much less than that on day 0.…”

Section: Results and Discussionmentioning

confidence: 99%

“…Spinosad, mainly composed of spinosyns A and D, is a fermentation product produced by actinomycete Saccharopolyspora spinosa . Structurally, the spinosyn family is composed of a central macrolide ring system (aglycon) with rhamnose and forosamine sugars at the 9- and 17-positions, respectively. , Spinosad is a widely used insecticide featuring high efficacy against Diptera, Thysanoptera, and especially Lepidopteran pests with low toxicity to nontarget organisms . However, shortcomings of conventional spinosad formulations such as easy photolysis or hydrolysis , result in their repeated and excessive application, which thereby leads to increased environmental risks , as well as relatively high costs.…”

Section: Introductionmentioning

confidence: 99%

“…Structurally, the spinosyn family is composed of a central macrolide ring system (aglycon) with rhamnose and forosamine sugars at the 9- and 17-positions, respectively. , Spinosad is a widely used insecticide featuring high efficacy against Diptera, Thysanoptera, and especially Lepidopteran pests with low toxicity to nontarget organisms . However, shortcomings of conventional spinosad formulations such as easy photolysis or hydrolysis , result in their repeated and excessive application, which thereby leads to increased environmental risks , as well as relatively high costs. Recently, sustained/controlled-release formulations of spinosad have shown great potential in reducing side effects of conventional formulations based on the advantages of small effective dose, prolonged release time, , and particularly specific environmental responsiveness. − …”

Section: Introductionmentioning

confidence: 99%

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Evaluation of a Spinosad Controlled-Release Formulation Based on Chitosan Carrier: Insecticidal Activity against Plutella xylostella (L.) Larvae and Dissipation Behavior in Soil

Wang

et al. 2021

ACS Omega

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Controlled-release pesticide formulations using natural polymers as carriers are highly desirable owing to their good biocompatibility, biodegradability, and improved pesticide utilization. In this study, the application potential of our previously prepared spinosad/chitosan controlled-release suspension (SCCS) was evaluated through both toxicity and dissipation tests. A comparison with the spinosad suspension concentrate and the commercial spinosad emulsion in water showed that the insecticidal activity of SCCS against Plutella xylostella larvae displayed the best quick-acting performance as well as long-term efficacy of more than 20 days. The 48 h LC50 for a 20-day efficacy was calculated to be 29.36 mg/L. The dissipation behavior of spinosad in the spinosad/chitosan microparticles in soil was found to follow the first-order kinetics, with a relatively shorter half-life (2.1 days) than that observed for the unformulated spinosad (3.1 days). This work showed the positive effect of chitosan on spinosad in improving insecticidal activity and reducing environmental risks in soil, which provided useful information on the application potential of pesticide–carrier systems based on natural polymer materials in crop protection and food safety.

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Section: Results and Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of a Spinosad Controlled-Release Formulation Based on Chitosan Carrier: Insecticidal Activity against Plutella xylostella (L.) Larvae and Dissipation Behavior in Soil

Wang

et al. 2021

ACS Omega

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“…The insecticide spinosad is manufactured from the bacterium Saccharopolyspora sinosa . It effectively reduced the density of vector mosquito larvae (Santos & Pereira, 2020 ). However, a modest effect of spinosad at a field concentration was found on Notonectidae (Hertlein et al, 2010 ) and Corixidae (Lawler & Dritz, 2013 ) in mesocosm experiments.…”

Section: Methodsmentioning

confidence: 99%

Pollution impacts on water bugs (Nepomorpha, Gerromorpha): state of the art and their biomonitoring potential

Bakonyi

Vásárhelyi²,

Szabó

2022

Environ Monit Assess

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As water pollution poses an increasing risk worldwide, it is timely to assess the achievements of the aquatic macroinvertebrate ecotoxicology to provide a sound basis for the discipline’s future and support the development of biomonitoring. Aquatic and semi-aquatic bugs (Hemiptera: Nepomorpha, Gerromorpha) are ubiquitous in almost all water types, sometimes in high densities, and play a significant role in organic material turnover and energy flow. Nevertheless, they are ignored in the water pollution biomonitoring schemes. Here, based on 300 papers, we review and evaluate the effects of chemical pesticides, microorganism-derived pesticides, insecticides of plant origin, heavy metals, eutrophication, salinisation and light pollution which are summarised for the first time. Our review encompasses the results of 100 laboratory and 39 semi-field/field experiments with 47 pesticides and 70 active ingredients. Pyrethroids were found to be more toxic than organochlorine, organophosphate and neonicotinoid insecticides to water bugs, like other macroinvertebrate groups. Additionally, in 10 out of 17 cases, the recommended field concentration of the pesticide was higher than the LC50 values, indicating potential hazards to water bugs. The recommended field concentrations of pesticides used in mosquito larvae control were found non-toxic to water bugs. As very few replicated studies are available, other findings on the effects of pesticides cannot be generalised. The microorganism-derived pesticide Bti appears to be safe when used at the recommended field concentration. Data indicates that plant-derived pesticides are safe with a high degree of certainty. We have identified three research areas where water bugs could be better involved in water biomonitoring. First, some Halobates spp. are excellent, and Gerris spp. are promising sentinels for Cd contamination. Second, Micronecta and, to a certain extent, Corixidae species composition is connected to and the indicator of eutrophication. Third, the species composition of the Corixidae is related to salinisation, and a preliminary method to quantify the relationship is already available. Our review highlights the potential of water bugs in water pollution monitoring.

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“…So far, more than 20 spinosyns analogues have been isolated and identified, among which the most effective constituents are spinosyn A and spinosyn D (spinosad) 4 . Spinosad affects the acetylcholine receptors of insects, causing muscle twitch and a sudden death 5 . Moreover, spinosad exhibits low mammalian toxicity and can be easily degraded 2 , 6 .…”

Section: Introductionmentioning

confidence: 99%

Comparative transcriptomic analysis of two Saccharopolyspora spinosa strains reveals the relationships between primary metabolism and spinosad production

Zhang¹,

Liu²,

Yin³

et al. 2021

Sci Rep

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Saccharopolyspora spinosa is a well-known actinomycete for producing the secondary metabolites, spinosad, which is a potent insecticides possessing both efficiency and safety. In the previous researches, great efforts, including physical mutagenesis, fermentation optimization, genetic manipulation and other methods, have been employed to increase the yield of spinosad to hundreds of folds from the low-yield strain. However, the metabolic network in S. spinosa still remained un-revealed. In this study, two S. spinosa strains with different spinosad production capability were fermented and sampled at three fermentation periods. Then the total RNA of these samples was isolated and sequenced to construct the transcriptome libraries. Through transcriptomic analysis, large numbers of differentially expressed genes were identified and classified according to their different functions. According to the results, spnI and spnP were suggested as the bottleneck during spinosad biosynthesis. Primary metabolic pathways such as carbon metabolic pathways exhibited close relationship with spinosad formation, as pyruvate and phosphoenolpyruvic acid were suggested to accumulate in spinosad high-yield strain during fermentation. The addition of soybean oil in the fermentation medium activated the lipid metabolism pathway, enhancing spinosad production. Glutamic acid and aspartic acid were suggested to be the most important amino acids and might participate in spinosad biosynthesis.

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Properties, toxicity and current applications of the biolarvicide spinosad

Cited by 36 publications

References 79 publications

Evaluation of a Spinosad Controlled-Release Formulation Based on Chitosan Carrier: Insecticidal Activity against Plutella xylostella (L.) Larvae and Dissipation Behavior in Soil

Evaluation of a Spinosad Controlled-Release Formulation Based on Chitosan Carrier: Insecticidal Activity against Plutella xylostella (L.) Larvae and Dissipation Behavior in Soil

Pollution impacts on water bugs (Nepomorpha, Gerromorpha): state of the art and their biomonitoring potential

Comparative transcriptomic analysis of two Saccharopolyspora spinosa strains reveals the relationships between primary metabolism and spinosad production

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