Prophylactic antibiotics for staged bone augmentation in implant dentistry

Abstract

Background: The objective of the study was to assess the effect of prophylactic antibiotics on the outcome of bone augmentation and subsequent dental implant placement by combining the recommended quality assessment methods for systematic reviews and primary studies. Materials and methods: This is a complex systematic review in which systematic reviews as well as primary studies are scrutinised. A search of Medline (OVID), The Cochrane Library (Wiley) and EMBASE, PubMed and Health technology assessment (HTA) organisations as-well as a complementary handsearch was carried out. Selected primary studies were assessed using GRADE. Each study was reviewed by three authors independently. Results: Abstract screening yielded six potential systematic reviews allocated for full-text inspection. A total of ten primary studies were read in full-text. No relevant systematic reviews regarding the topic of this article were found. The quality assessment resulted in two primary studies with a moderate risk of bias. Of the two studies with a moderate risk of bias, one compared a single dose of clindamycin 600 mg preoperatively with the same preoperative dose followed by four doses of 300 mg every 6 h. The second study compared a single dose prophylaxis of two different types of antibiotic compounds. Conclusion:In conclusion, the scientific evidence regarding the use of antibiotic prophylaxis for reducing the risk of infection in conjunction with bone augmentation procedures during dental implant placement is very limited. The infection rate as compared to nonusage of prophylactic antibiotics, selection of the most suitable compound, and the optimal duration of prophylactic treatment is still unknown.

Hydroxyapatite Consolidated by Zirconia: Applications for Dental Implant

“…Implant dentistry is a prosthetic effort via a surgical procedure [32,33]. In order to achieve an ideal prosthetic construct, precise plan should be taken into consideration prior to the beginning of treatment.…”

Antibiotics to Prevent Surgical Site Infection (SSI) in Oral Surgery: Survey among Italian Dentists

“…Similarly, since the use of hemostatic materials or sutures (C3) in non-surgical extractions does not increase the risk of SSI [ 12 ], the use of antibiotics is not justified, as indicated by 82.2% of the participants. Conversely, in the case of ridge preservation procedures with bone grafting (C4), 83.4% of participants agreed on the need for antibiotics, though literature data are scarce and conflicting on this issue [ 39 , 40 ], and it has been suggested that a single preoperative dose (2 or 3 g of amoxicillin) would be sufficient to prevent SSI after bone regeneration procedures [ 41 ].…”

Is clindamycin effective in preventing infectious complications after oral surgery? Systematic review and meta-analysis of randomized controlled trials

“…After full-text assessment, 7 were included in qualitative synthesis. First, all articles that did not analyze the infection clinically Excluded: no control group with placebo or without treatment Bone grafts along with implant placement Lindeboom JA, 2005 [18] Excluded: no control group with placebo or without treatment Lindeboom JA, 2006 [19] Excluded: no control group with placebo or without treatment Klinge A, Khalil D, Klinge B et all 2020 [20] Excluded: It is a review Orthognathic surgery Lindeboom JA, Baas EM, Kroon FH 2003 [21] Excluded: no control group with placebo or without treatment Baqain ZH, Hyde N, Patrikidou A, Harris M.2004 [22] Excluded: no control group with placebo or without treatment Davis CM, Gregoire CE, Davis I, Steeves TW.2017 [23] Excluded: no control group with placebo or without treatment Oncologic surgery Righi M, Manfredi R, Farneti G, et all 1995 [24] Excluded: no control group with placebo or without treatment Head and neck surgery Mann W, Maurer J, Wolfensberger M, et all 1990 [25] Excluded: no control group with placebo or without treatment Clayman GL, Raad II, Hankins PD et all 1993 [26] Excluded: no control group with placebo or without treatment Endodontic procedure Raslan N, Mansour O, Assfoura L. 2017 [27] Excluded: no control group with placebo or without treatment Endodontic surgery Lindeboom JA, Frenken JW, Valkenburg et all 2005 [28] Included Dental extraction Laird WR 1972 [29] Excluded: no control group with placebo or without treatment Bystedt 1980 [30] Excluded: did not report data in a form suitable for inclusion Kupfer 1995 [15] Excluded: it is not a RCT Poeschl 2003 [31] Included &Foy SP, Shugars DA, Phillips C, et all 2004 [32] Excluded: did not report data in a form suitable for inclusion a Halpern LR,0.2007 [12] Included Kaczmarzyk 2007 [33] Included Adde, 2012 [34] Included *Hamiti-Krasniqi 2014 [35] Included Xue 2014 [36] Excluded: patients included in another study. It was not possible to contact the authors to confirm this Xue 2015 [13] Excluded: did not report data in a form suitable for inclusion Kaposvári 2017 [37] Included were excluded.…”