Prophylactic augmentin in prelabor preterm rupture of the membranes

Magwali, Thulani; Chipato, Tsungai; Majoko, Franz; Rusakaniko, S; Mujaji, C.

doi:10.1016/s0020-7292(99)00036-3

Cited by 21 publications

(20 citation statements)

References 6 publications

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“…The findings of 3 other studies [373][374][375] conducted in developing countries largely corroborated findings from studies in developed countries, although data are very limited (Table 19). No trials of antibiotic therapy for PPROM, however, have been conducted solely in community settings in developing countries.…”

Section: Antibiotics For Preterm Laborsupporting

confidence: 66%

Community-Based Interventions for Improving Perinatal and Neonatal Health Outcomes in Developing Countries: A Review of the Evidence

et al. 2005

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ABSTRACT. Background. Infant and under-5 childhood mortality rates in developing countries have declined significantly in the past 2 to 3 decades. However, 2 critical indicators, maternal and newborn mortality, have hardly changed. World leaders at the United Nations Millennium Summit in September 2000 agreed on a critical goal to reduce deaths of children <5 years by two thirds, but this may be unattainable without halving newborn deaths, which now comprise 40% of all under-5 deaths. Greater emphasis on wide-scale implementation of proven, cost-effective measures is required to save women's and newborns' lives. Approximately 99% of neonatal deaths take place in developing countries, mostly in homes and communities. A comprehensive review of the evidence base for impact of interventions on neonatal health and survival in developingcountry communities has not been reported.Objective. This review of community-based antenatal, intrapartum, and postnatal intervention trials in developing countries aimed to identify (1) key behaviors and interventions for which the weight of evidence is sufficient to recommend their inclusion in communitybased neonatal care programs and (2) key gaps in knowledge and priority areas for future research and program learning.Methods. Available published and unpublished data on the impact of community-based strategies and interventions on perinatal and neonatal health status outcomes were reviewed. Evidence was summarized systematically and categorized into 4 levels of evidence based on study size, location, design, and reported impact, particularly on perinatal or neonatal mortality. The evidence was placed in the context of biological plausibility of the intervention; evidence from relevant developed-country studies; health care program experience in implementation; and recommendations from the World Health Organization and other leading agencies.Results. A paucity of community-based data was found from developing-country studies on health status impact for many interventions currently being considered for inclusion in neonatal health programs. However, review of the evidence and consideration of the broader context of knowledge, experience, and recommendations regarding these interventions enabled us to categorize them according to the strength of the evidence base and confidence regarding their inclusion now in programs. This article identifies a package of priority interventions to include in programs and formulates research priorities for advancing the state of the art in neonatal health care.Conclusions. This review emphasizes some new findings while recommending an integrated approach to safe motherhood and newborn health. The results of this study provide a foundation for policies and programs related to maternal and newborn health and emphasizes the importance of health systems research and evaluation of interventions. The review offers compelling support for using research to identify the most effective measures to save newborn lives. It also may facilitate dialogue with policy...

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Section: Antibiotics For Preterm Laborsupporting

confidence: 66%

Community-Based Interventions for Improving Perinatal and Neonatal Health Outcomes in Developing Countries: A Review of the Evidence

et al. 2005

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“…Outcomes of PPROM depend on the gestational age and the condition of chorioamnionitis (34). Since most of the neonatal complications of PPROM are because of preterm labor, prolonging the interval between rupture of the membrane and the occurrence of labor by appropriate interventions may reduce prenatal mortality and morbidity (35).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Maternal Risk Factors, Delivery, and Neonatal Outcomes of Premature Rupture of Membrane: A Systematic Review Study

Boskabadi

Zakerihamidi

2018

J. Pediatr. Rev.

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Context: Premature rupture of membrane is a serious complication in pregnancy and responsible for one third of preterm labors associated with the neonatal and delivery outcomes.Objective: The current study aimed at investigating the risk factors of premature rupture of membrane on delivery and neonatal implications. Data Sources:The articles on the databases, including PubMed, Cochrane Library, ISI and Google Scholar up to 2017 were searched to conduct the current study. The keywords used were "premature rupture of membrane", "neonatal," "risk factors", "maternal", and "delivery". Study Selection:The inclusion criteria were articles on the relationship between maternal risk factors and Premature Rupture of Membrane (PROM), neonatal outcomes of PROM, the delivery outcomes of PROM, the study of mothers and infants, English and Persian language articles, and sufficient information on the PROM. The articles investigating amniotomy or the ones that only their abstracts were available were excluded from the study.Data Extraction: The data extracted from the above mentioned databases were fed with the following titles in the Excel software: Authors' names and surnames, year of study, type of study, place of study, case group, control group, maternal risk factors, delivery outcomes, neonatal outcomes of PROM, and the results of the study. Results:Out of 90 articles, 15 articles were finalized including one prospective study, five crosssectional papers, six retrospective articles, and three historical cohort studies. Maternal risk factors included age; parity; education; occupation; diabetes; blood pressure; cervical length along with abortion history; history of infection, upper urinary tract infection, and sexually transmitted diseases. Moreover, delivery complications were cesarean section, oligohydramnios, chorioamnionitis, and placental abruption. Neonatal complications included prematurity, respiratory distress syndrome, asphyxia, infection, meningitis, sepsis, pneumonia, perinatal mortality, patent arterial duct, necrotizing enterocolitis, IVH, pulmonary hypoplasia, hyperbilirubinemia, and antibiotic intake. Conclusions:Based on the results of the current study, the most important risk factors for PROM were diabetes and maternal hypertension associated with neonatal and maternal complications. Infection was the most important maternal and neonatal complication. Citation: Boskabadi H, Zakerihamidi M. Evaluation of Maternal Risk Factors, Delivery, and Neonatal Outcomes of Premature Rupture of Membrane: A Systematic Review Study. Journal of Pediatrics Review. 2019; 7(2):77-88. http://dx.

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“…For patients with PPROM and a positive or unknown GBS culture, antibiotic therapy is recommended to prevent or treat ascending intrauterine infection (21). Due to the administration of antibiotics, pregnancy will be prolonged and both maternal and neonatal infectious morbidity is decreased (62, 63). Unfortunately, the majority of cases of IAI in the setting of PPROM do not produce the signs and symptoms traditionally used as diagnostic criteria for clinical chorioamnionitis.…”

Section: During Deliverymentioning

confidence: 99%

Morbidity related to maternal group B streptococcal infections

Muller

Oostvogel

Steegers

et al. 2006

Acta Obstet Gynecol Scand

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Group B streptococcus is known to be a leading cause of neonatal infection, but less appreciated is the fact that it causes maternal infection also. Maternal group B streptococcal infections during pregnancy and delivery threaten not only the mother, but the child as well. Postpartum infection, such as mastitis, bacteremia, sepsis, meningitis, endometritis, and wound infections are hazards to the mother. We describe the various maternal group B streptococcal infections, their characteristics, associated neonatal morbidity, and prevention and treatment strategies during pregnancy, delivery, and in the postpartum period.

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Prophylactic augmentin in prelabor preterm rupture of the membranes

Abstract: The use of prophylactic Augmentin in PPROM significantly prolongs gestation. It appears to decrease neonatal and maternal morbidity due to sepsis.

Cited by 21 publications

References 6 publications

Community-Based Interventions for Improving Perinatal and Neonatal Health Outcomes in Developing Countries: A Review of the Evidence

Community-Based Interventions for Improving Perinatal and Neonatal Health Outcomes in Developing Countries: A Review of the Evidence

Evaluation of Maternal Risk Factors, Delivery, and Neonatal Outcomes of Premature Rupture of Membrane: A Systematic Review Study

Morbidity related to maternal group B streptococcal infections

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