Prophylactic heparin and risk of orotracheal intubation or death in patients with mild or moderate COVID-19 pneumonia

Abstract

Prophylactic low molecular weight heparin (pLMWH) is currently recommended in COVID-19 to reduce the risk of coagulopathy. The aim of this study was to evaluate whether the antinflammatory effects of pLMWH could translate in lower rate of clinical progression in patients with COVID-19 pneumonia. Patients admitted to a COVID-hospital in Rome with SARS-CoV-2 infection and mild/moderate pneumonia were retrospectively evaluated. The primary endpoint was the time from hospital admission to orotracheal intubation/death (OTI/death). A total of 449 patients were included: 39% female, median age 63 (IQR, 50–77) years. The estimated probability of OTI/death for patients receiving pLMWH was: 9.5% (95% CI 3.2–26.4) by day 20 in those not receiving pLMWH vs. 10.4% (6.7–15.9) in those exposed to pLMWH; p-value = 0.144. This risk associated with the use of pLMWH appeared to vary by PaO2/FiO2 ratio: aHR 1.40 (95% CI 0.51–3.79) for patients with an admission PaO2/FiO2 ≤ 300 mmHg and 0.27 (0.03–2.18) for those with PaO2/FiO2 > 300 mmHg; p-value at interaction test 0.16. pLMWH does not seem to reduce the risk of OTI/death mild/moderate COVID-19 pneumonia, especially when respiratory function had already significantly deteriorated. Data from clinical trials comparing the effect of prophylactic vs. therapeutic dosage of LMWH at various stages of COVID-19 disease are needed.

Know an Emotion by the Company It Keeps: Word Embeddings from Reddit/Coronavirus

“…olfactory, (0.463) [72], parkinson (0.459) [73], aspirin (0.496) [74] antibody A protein that is produced in response to the introduction of an antigen in an organism monoclonal (0.436) [75], regeneron (0.478) [76], serological (0.475) [77], bamlanivimab (0.539) [78] antiviral Medication used for treating viral infections favipiravir (0.341) [79], remdesivir (0.344) [80], heparin (0.379) [81], interferón (0.385) [82], ritonavir (0.435) [83] In Table 3, we show the closest terms retrieved by our model and their cosine distances to representative definitions from the initial terms of the glossary (terms starting with the 'A' letter). For each of the terms identified by our trained model, we included relevant published scientific literature.…”

Intersection of Resilience and COVID-19: Structural Topic Modelling and Word Embeddings from Reddit Titles (Preprint)

“…glucose (0.461) [46], epithelium (0.461) [47] , anticoagulant (0.481) [48] anosmia The complete or partial loss of the sense of smell. olfactory (0.463) [49] , parkinson (0.459) [50] , aspirin (0.496) [51], loss (0.483), senses (0.483) antibody A protein that is produced in response to the introduction of an antigen in an organism monoclonal (0.436) [52], regeneron (0.478) [53], serological (0.475) [54], bamlanivimab (0.539) [55], antigen (0.489), lilly (0.515) [56], eli (0.493) [ [58], microdroplets (0.486), particles (0.383), transmission (0.414), exhaled (0.428), fomite (0.382) [59], hvac (0.460) [60] antiviral medication used for treating viral infections favipiravir (0.341) [61], remdesivir (0.344) [62], heparin (0.379) [63], interferón (0.385) [64], gilead (0.402) [65], avigan (0.423) [66], ritonavir (0.435) [67] antigen A substance that, when introduced in an organism, induces an immune response. rapid (0.272), kit (0.363), diagnostic (0.363) [68], igm (0.435), igg (0.432) [69], cepheid (0.496) [70], sona (0.501) [71],…”