Prophylaxis of Malaria

Schwartz, Eli

doi:10.4084/mjhid.2012.045

Cited by 23 publications

(10 citation statements)

References 26 publications

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“…Furthermore, ELQ‐400 was evaluated in a causal prophylaxis assay and found to be capable of inhibiting LS infection by firefly luciferase‐expressing P. yoelii (PyLuc) sporozoites . LS (causal) prophylaxis refers to drugs that are active against malaria parasites within the hepatocytes, that is, PQ and malarone . Remarkably, a single dose of ELQ‐400 when administered orally 1 hr after sporozoite inoculation completely prevented the development of both LS and blood‐stage infections at oral doses as low as 0.08 mg/kg.…”

Section: Chemical Compounds Effective Against Various Life Stagesmentioning

confidence: 99%

Multistage inhibitors of the malaria parasite: Emerging hope for chemoprotection and malaria eradication

Poonam

Gupta

et al. 2018

Medicinal Research Reviews

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Over time, several exciting advances have been made in the treatment and prevention of malaria; however, this devastating disease continues to be a major global health problem and affects millions of people every year. Notably, the paucity of new efficient drug molecules and the inevitable drug resistance of the malaria parasite, Plasmodium falciparum, against frontline therapeutics are the foremost struggles facing malaria eradication initiatives. According to the malaria eradication agenda, the discovery of new chemical entities that can destroy the parasite at the liver stage, the asexual blood stage, the gametocyte stage, and the insect ookinete stage of the parasite life cycle (i.e., compounds exhibiting multistage activity) are in high demand, preferably with novel and multiple modes of action. Phenotypic screening of chemical libraries against the malaria parasite is certainly a crucial step toward overcoming these crises. In the last few years, various research groups, including industrial research laboratories, have performed large-scale phenotypic screenings that have identified a wealth of chemical entities active against multiple life stages of the malaria parasite. Vital scientific and technological developments have led to the discovery of multistage inhibitors of the malaria parasite; these compounds, considered highly valuable starting points for subsequent drug discovery and eradication of malaria, are reviewed.

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Section: Chemical Compounds Effective Against Various Life Stagesmentioning

confidence: 99%

Multistage inhibitors of the malaria parasite: Emerging hope for chemoprotection and malaria eradication

Poonam

Gupta

et al. 2018

Medicinal Research Reviews

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“…Los virus de la fiebre amarilla y dengue, diseminados por dipteros del género Aedes (Patterson et al, 2016), o bien, el parásito Trypanosoma cruzi agente causal de la enfermedad de Chagas transmitido por chinches de los géneros Triatoma y Rhodnius, son ejemplos de estos patógenos (González y Hernández, 2017;Pita et al, 2018). Establecida la relación tripartita entre patógeno-vector-huésped, para reducir el impacto de las ETV existen técnicas de control, como vacunas implementadas en contra del dengue (Sridhar et al, 2018), o métodos quimioprofilácticos en el caso del paludismo (Schwartz, 2012). No obstante, el control de poblaciones de vectores permanece como el método de primera elección para el manejo de las ETV.…”

Section: Panorama De Las Etv En Méxicounclassified

Políticas públicas para el control de enfermedades transmitidas por vectores en México

Juache-Villagrana

Flores

2021

RESPYN

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Las enfermedades transmitidas por vectores (ETV) persisten como un problema nacional de salud pública. A fin de disminuir su impacto, existen políticas públicas dirigidas al manejo de estas infecciones. Las soluciones propuestas, así como su implementación, se estipulan dentro de documentos como la ley general de salud (LGS) y normas oficiales mexicanas (NOM). Pese a que la ejecución de las políticas públicas ha conducido a resultados favorables en contra de las ETV, existen nuevas pautas internacionales establecidas por la Organización Mundial de la Salud (OMS) que incrementarían la eficacia de las políticas actuales. Objetivo: Contrastar las acciones estipuladas en las políticas públicas mexicanas del 2000 a 2020 para el combate a las ETV contra las directrices internacionales actuales. Conclusiones: La mayoría de las actividades en contra de las ETV recaen dentro del control de vectores, mismo que al ser comparado con las directrices de la OMS exhibe áreas de oportunidad en la escala de aplicación, uso de insecticidas, participación comunitaria, investigación, entre otras. Bajo este escenario, las políticas públicas deben actualizarse para incluir nueva información propuesta por organismos internacionales.

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“…The most commonly recommended regimens of chemoprophylaxis are as follows: doxycycline 100 mg once daily (started one day before traveling, and continued for four weeks after returning); mefloquine 250 mg once weekly (started 2.5 weeks before traveling, and continued for four weeks after returning); atovaquone/proguanil one tablet daily (started one day before traveling, and continued for one week after returning) [27].…”

Section: Chemoprophylaxismentioning

confidence: 99%

Malaria in the 21st century - still a threatening problem

Čanović

Jovicić

Pavlović³

2019

Srp Arh Celok Lek

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There are six parasite species (P. falciparum, P. vivax, P. ovale curtisi, P. ovale wallikeri, P. malariae, and P. knowlesi) that cause malaria in humans. P. falciparum is responsible for most malaria-related deaths globally. P. vivax is the dominant malaria parasite in most countries outside of the Sub-Saharan Africa. In 2016, 91 countries reported a total of 216 million cases of malaria. The global tally of malaria deaths reached 445,000. In 2016, 24 cases of imported malaria were registered in the Republic of Serbia, with an incidence of 0.33/100,000. According to the World Health Organization recommendations, every suspected malaria case should be confirmed by microscopy or a rapid diagnostic test before treatment. The main stone of antimalarial therapy should be artemisinin-based combinations. Since malaria occurs in Europe as an imported (though rarely also autochthonous and a hospital-borne infection), the objective of this paper is to point out current problems and attitudes in the diagnosis and treatment of malaria, without entering the data field significant for professionals (infectologists, epidemiologists, intensivists).

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Prophylaxis of Malaria

Cited by 23 publications

References 26 publications

Multistage inhibitors of the malaria parasite: Emerging hope for chemoprotection and malaria eradication

Multistage inhibitors of the malaria parasite: Emerging hope for chemoprotection and malaria eradication

Políticas públicas para el control de enfermedades transmitidas por vectores en México

Malaria in the 21st century - still a threatening problem

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