Prophylaxis of the Thrombo-Embolic Disease with Subcutaneous Low Doses of Heparin and Intrapulmonary Application of Heparin with Aerosol Inhalation

Aerosolized Heparin

“…In all studies an increase of APTT, with a marked prolongation of up to 3 weeks (19), was found. The highest concentration of heparin determined in the blood was 0.18 U/ml (13). Similar data were obtained with low molecular weight heparin (30).…”

“…Higher doses of up to 190.000 U heparin (volume fill into the nebulizer) were administered to volunteers using ultrasonic nebulizers (13,19,26) to test the influence on the blood clotting system. In all studies an increase of APTT, with a marked prolongation of up to 3 weeks (19), was found.…”