Propionyl-l-carnitine prevents renal function deterioration due to ischemia/reperfusion

Mister, Marilena; Noris, Marina; Szymczuk, Jarosław; Azzollini, Nadia; Aiello, Sistiana; Abbate, Mauro; Trochimowicz, Lech; Gagliardini, Elena; Arduini, Arduino; Perico, Norberto; Remuzzi, Giuseppe

doi:10.1046/j.1523-1755.2002.00212.x

Cited by 66 publications

(49 citation statements)

References 57 publications

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“…In general, PP of kidneys is considered to function through stabilization of the organ by supplying nutrients and oxygen during storage, by decreasing intrarenal vasospasm and by removal of waste materials while mimicking circulation and increasing vascular compliance. Numerous diagnostic procedures and perfusate modifications have been introduced for PP throughout its evolution (21)(22)(23)(24)(25). Despite the abundance of literature examining these issues and novel technical methodologies, opinions regarding the ultimate efficacy of PP are mixed.…”

Section: Introductionmentioning

confidence: 99%

Are We Frozen in Time? Analysis of the Utilization and Efficacy of Pulsatile Perfusion in Renal Transplantation

Schold

Kaplan

Howard

et al. 2005

American Journal of Transplantation

146

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Preservation techniques are crucial to deceased donor kidney transplantation (DDTx), but the efficacy of pulsatile perfusion (PP) versus cold storage (CS) remains uncertain. We describe patterns of PP use and explore four fundamental questions. What kidneys are selected for PP? How does PP affect utilization of donated kidneys? What effect does PP have on outcomes? When does PP appear to be most efficacious? We examined rates of PP in DDTx in the United States from 1994 to 2003. We generated models for organ utilization, delayed graft function (DGF) and for the use of PP. We analyzed the long-term effect of PP with multivariate Cox models. The utilization rates for nonexpanded criteria donors (ECDs) were similar by storage type, but for ECDs there was a significantly higher utilization rate with PP (70% with PP vs. 59% with CS, p < 0.001). Use of PP was widely variable across transplant centers. DGF rates were significantly lower with PP (27.6% vs. 19.6%). PP was associated with a mild benefit on death censored graft survival (adjusted hazard ratio = 0.88, 95% CI 0.85-0.91). Reduced DGF and significantly lower discard rates of ECDs associated with PP suggest an important utility of PP in renal transplantation. Additional evidence of improvement in graft survival, particularly in more recent years, provides further encouraging evidence for the use of PP.

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Section: Introductionmentioning

confidence: 99%

Are We Frozen in Time? Analysis of the Utilization and Efficacy of Pulsatile Perfusion in Renal Transplantation

Schold

Kaplan

Howard

et al. 2005

American Journal of Transplantation

146

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“…In many studies serum and/or tissue MDA levels were shown as increased. 19,20,22,[44][45][46][47] In our study, serum creatinine and tissue MDA levels were significantly higher in AIR group than other groups. Also there was a positive correlation between serum creatinine and tissue MDA levels and between creatinine values and TSHD.…”

Section: Discussionmentioning

confidence: 72%

“…Mister et al showed in their studies with the same method that carnitine protected phospholipids and cellular membrane integrity by preventing lipid peroxidation and release of free oxygen radicals. Mister et al 20 also showed that carnitine prevented increase in MDA levels in kidneys after reperfusion. Besides, carnitine also prevents increase in MDA levels in IR damage in several organs and in renal damage caused by several agents.…”

Section: Discussionmentioning

confidence: 94%

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The Role of Carnitine in Preventing Renal Damage Developed as a Result of Infrarenal Aortic Ischemia–Reperfusion

et al. 2011

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Background: This study was designed to use carnitine for preventing deposition of end products of lipid peroxidation in rat models in the prevention of ischemia-reperfusion (IR) damage frequently seen following operations of infrarenal abdominal aorta (AA). Methods: Forty male rats of Sprague-Dawley type were evenly (n = 8) randomized to five groups: sham laparotomy (SHAM), carnitine control (CC), aortic IR (AIR), AIR + low-dose carnitine (AIR+LDC), and AIR + high-dose carnitine (AIR+HDC). Results: Compared to other groups, serum creatinine levels of AIR group were significantly higher. Also tissue malondialdehyde (MDA) levels of AIR group were significantly higher compared to SHAM, CC, and AIR+HDC groups. In histopathological examination, although tubular necrosis atrophy and tubular degeneration observed in AIR group showed regression with low-dose carnitine, tubular necrosis atrophy, tubular degeneration, glomerular damage, and vascular congestion thrombosis decreased with high-dose carnitine. Total score of histological damage was significantly higher in AIR, AIR+LDC, and AIR+HDC groups compared to SHAM and CC groups. Moreover, total score of histological damage was significantly lower in AIR+HDC group than AIR+LDC group. Conclusions: In this study, we showed carnitine can partially prevent renal damage in infrarenal AIR models of rats. This result may open new prospects to us in the prevention of renal IR damage during surgery of aorta.

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“…(9)(10)(11)(12). Administration of L-carnitine or its derivatives were documented to improve I/R injury of the heart, kidney, skeletal muscle, and brain (3,(13)(14)(15)(16).…”

Section: Introductionmentioning

confidence: 99%

The protective effect of L-carnitine on hepatic ischemia-reperfusion injury in rats

Çekın

Gür²,

Türkoğlu³

et al. 2009

Turk J Gastroenterol

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Amaç: ‹skemi-reperfüzyon hasar› klinik pratikte karaci¤er nakli ile ilgili ciddi bir komplikasyon olmaya devam etmektedir. Bu çal›fl-ma, s›çanlarda deneysel hepatik iskemi-reperfüzyon hasar› üzerine L-karnitinin etkisini de¤erlendirmek için tasarlanm›flt›r. Gereç ve Yöntem: Toplam 45 erkek Grup 3'den (267.6(56.6 )U/L); ortalama (SD) alanin aminotransferaz de¤erleri Grup 2 (257(97.7)U/L) için Grup 1 (37.2(6.6)U/L) ve Grup 3'den (118.1(46.7)U/L); ortalama (SD) laktat dehidrogenaz de¤erleri Grup 2 (2943.8(166.1)U/L) için Grup 1 (1496.5(274.8)U/L) ve Grup 3'den (2185.3(258.7)U/L); ortalama (SD) doku malondialdehit düzey-leri Grup 2 (54.3(2.8)nmol/gr) için Grup 1 (41.0(1.4)nmol/gr) ve Grup 3'den (42.1(3.8)Anahtar kelimeler: L-karnitin, hepatik iskemi-reperfüzyon hasar›, antioksidan, lipit peroksidasyonu Background/aims: Ischemia-reperfusion injury may occur during liver transplantation and remains a serious concern in clinical practice. This study was designed to study the potential benefit of L-carnitine on experimental warm hepatic ischemia-reperfusion injury in rats. Materials and Methods: Forty-five male Wistar Albino rats were divided into three groups; Group 1 sham-operation without ischemia-reperfusion (n=15); Group 2, ischemia-reperfusion (n=15); and Group 3, which was administered L-carnitine (200 mg/kg, intraperitoneal, for 4 days) prior to ischemia-reperfusion (n=15

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Propionyl-l-carnitine prevents renal function deterioration due to ischemia/reperfusion

Cited by 66 publications

References 57 publications

Are We Frozen in Time? Analysis of the Utilization and Efficacy of Pulsatile Perfusion in Renal Transplantation

Are We Frozen in Time? Analysis of the Utilization and Efficacy of Pulsatile Perfusion in Renal Transplantation

The Role of Carnitine in Preventing Renal Damage Developed as a Result of Infrarenal Aortic Ischemia–Reperfusion

The protective effect of L-carnitine on hepatic ischemia-reperfusion injury in rats

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