Perioperative anaphylaxis is a rare and life-threatening condition, with a mortality rate of 3%–9%. Several anesthetic agents are often used during general anesthesia, and all the anesthetics tend to cause allergic reactions and anaphylaxis. Anaphylaxis due to propofol is very uncommon, which can occur in 1.2% of cases of perioperative anaphylactic shock. We report a case of a 64 year-old female patient who has suffered from anaphylaxis after being given propofol during the anesthesia induction.