Propofol: Application in veterinary sedation and anesthesia

Glowaski, Maria M.; Wetmore, Lois A.

doi:10.1016/s1096-2867(99)80021-8

Cited by 50 publications

(50 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is possible that at low doses propofol has a disinhibitory effect, and at higher doses it has an antiepileptogenic effect by raising the excitatory threshold (Baraka and Aoud, 1997). Conversely, Glowaski and Wetmore (1999) reported that propofol in low dosage did not cause excitement and the authors Fig. 3.…”

Section: Discussionmentioning

confidence: 96%

Quantitative electroencephalographic findings in beagles anaesthetized with propofol

Bergamasco

Accatino²,

Priano

et al. 2003

The Veterinary Journal

View full text Add to dashboard Cite

The purpose of this study was to assess quantitative electroencephalography (q-EEG) in 10 healthy beagle dogs under propofol anaesthesia in order to determine objective guidelines for diagnostic electroencephalographic (EEG) recordings and interpretation. The basic pattern after preliminary visual examination of EEG recordings was characterized by spindles, k-complexes, vertex sharp transients, and positive occipital transients that were superimposed on the slow background activity. The results of the q-EEG were characterized by the prevalence of slow rhythms d and h, both in absolute and relative power spectrum analysis, while fast rhythms (a and b) were poorly represented. The distribution of single frequency bands was widespread for d, focal for frontal and central for h, as well as for most a and b patterns. The present study has shown that the use of quantitative EEG gives information on the frequency content of the bio-electrical activity and defines the distribution of the single frequency bands under a standardized anaesthetic protocol.

show abstract

Section: Discussionmentioning

confidence: 96%

Quantitative electroencephalographic findings in beagles anaesthetized with propofol

Bergamasco

Accatino²,

Priano

et al. 2003

The Veterinary Journal

View full text Add to dashboard Cite

show abstract

“…Propofol alone has proved to be unsatisfactory for major surgical procedures as it has no analgesic properties and the dose required to suppress responses to surgical manipulations induces severe cardiovascular and respiratory adverse effects 1,6,8,12,21 . Thus, it may be combined with some opioids like remifentanil or fentanyl.…”

Section: Discussionmentioning

confidence: 99%

“…Propofol is a short-acting, nonbarbiturate sedative drug, which is rapidly metabolized in dogs [1][2][3][4] . Minimal accumulation on repeated or constant administration makes propofol suitable for both the induction and maintenance of anesthesia [5][6][7] .…”

Section: Introductionmentioning

confidence: 99%

Comparison of Propofol-Remifentanil and Propofol-Fentanyl Anesthesia During Ovariohysterectomy in Dogs

Kürüm¹,

Pekcan²,

Kalender³

et al. 2013

Kafkas Univ Vet Fak Derg

View full text Add to dashboard Cite

The aim of the study was to evaluate the cardiorespiratory and clinical effects of propofol and remifentanil anesthesia compared to propofol and fentanyl anesthesia during ovariohysterectomy in dogs. Sixteen healthy dogs were randomly assigned to two groups. After premedication with atropine, anesthesia was induced with propofol and maintained with the infusion of propofol at a dose of 0.5 mg/kg/min. Once stable anesthesia was achieved, 1 µg/kg remifentanil or 2 µg/kg fentanyl was administered intravenously, and infusion was begun at a dose of 0.6 µg/kg/min and 0.5 µg/kg/min, respectively. Cardiorespiratory variables were recorded after propofol administration combined with remifentanil or fentanyl at 10-min intervals, and the quality of anesthesia, return of spontaneous ventilation, head lift and sternal position were also recorded. Apnea was observed after remifentanil and fentanyl administration in all dogs. Heart rate, systolic and mean arterial blood pressures tended to decrease rapidly after remifentanil and fentanyl administration, and during the first 20 min, in both groups. Although the difference between times was significant, the difference between groups was statistically insignificant. Recovery periods were longer in the fentanyl group than in the remifentanil group. The administration of propofol with remifentanil or fentanyl provides a stable haemodynamic state and depth of anesthesia with a constant infusion, and remifentanil could be preferred to fentanyl when aiming a rapid recovery period. Propofol, Remifentanil, Fentanyl, Anesthesia, Cardiorespiratory, Recovery, Dog Köpeklerde Ovariohisterektomi Operasyonunda Propofol-Remifentanil ve Propofol-Fentanil Anestezisinin Karşılaştırılması Keywords: ÖzetBu çalışmanın amacı köpeklerde ovariohysterektomi operasyonunda propofol-remifentanil ile propofol-fentanil anestezisinin etkinliğini ve kardiyorespiratorik etkilerini karşılaştırmaktır. Bu amaçla 16 adet yetişkin, dişi köpek rastgele iki gruba (n=8) ayrıldı. Anesteziye atropin ile premedikasyon yapılarak başlandıktan sonra propofol ile indüksiyon yapıldı ve 0.5 mg/kg/dk dozunda propofol infüzyonuna başlandı. Stabil anesteziden sonra ilk gruba 1 µg/kg remifentanil, ikinci gruba 2 µg/kg fentanyl bolus olarak uygulandı. Remifentanil ve fentanil infüzyonu sırasıyla 0.6 µg/kg/dk ve 0.5 µg/kg/dk dozunda devam edildi. Kardiyovasküler değişiklikler propofol sonrası, remifentanil veya fentanil sonrası ve operasyon süresince 10 dakika aralıklarla kaydedildi. Anestezinin derinliği, spontan ventilasyonun başlama, kafayı kaldırma ve sternal pozisyona gelme zamanları kaydedildi. Tüm olgularda remifentanil ve fentanil uygulamasından sonra apnea oluşumu gözlendi. Her iki grupta da kalp atım hızı, sistolik (SAP) ve ortalama arteriyel basınç (MAP) değerlerinin remifentanil ve fentanil uygulanmasından sonra hızla düştüğü ve ilk 20 dakikada düşmeye devam ettiği görüldü. Bu değerlerde zaman içindeki farklılıklar istatistiksel olarak anlamlı olarak kaydedilirken, gruplar arasında istatistiksel açıdan anlamlı olmadığı ...

show abstract

“…infüzyon dozu kullanılan anestezik ilaca bağlı olarak değişmekle birlikte, 0.15-0.5 mg/kg/dk arasındadır (2,7). Hayvanlarda olduğu gibi insanlarda da yaygın kullanım alanı olan propofolün uygulamasına ilişkin rapor edilen sporadik komplikasyon vakaları vardır.…”

Section: Introductionunclassified

Köpeklerde kısa süreli uygulanan propofolün pankreatitis oluşumuna etkisi

Pekcan¹,

Karaisaoğlu²

2017

Ankara Üniversitesi Veteriner Fakültesi Dergisi

View full text Add to dashboard Cite

Özet: İlaca bağlı pankreatitis şekillenmesi nadir olmakla beraber bugüne kadar 85'in üzerinde değişik ilacın pankreatitise neden olduğu bildirilmiştir. Yakın tarihte FDA'ya propofol uygulanmasından sonra pankreatitis geliştiğini bildiren 25 ayrı vaka bildirimi vardır. Veteriner çalışmalarında ise propofol uygulaması sonrasında hiperlipidemi ve trigliserid seviyesinde yükselmeler olduğu bildirilmesine rağmen, pankreas üzerine muhtemel etkisi araştırılmamıştır. Bu çalışmanın amacı, propofol uygulanmasının pankreas üzerine etkilerini değerlendirmektir. Çalışmada 20 sağlıklı köpek en az bir saat süre ile anesteziye alındı. Hayvanlardan anestezi öncesinde ve sırasında, uyanma sırasında, uyandıktan 4 ve 24 saat sonra kan alınarak serum amilaz, lipaz, kolesterol, trigliserid, ALP, AST, GGT, cPLI, kalsiyum ve glikoz seviyeleri değerlendirildi. Buna göre anestezi sırasında serum glikoz, kalsiyum ve trigliserid değerleri yük-selirken amilaz, lipaz, ALP, AST, kolesterol ve GGT değerlerinin düştüğü kaydedildi. Serum cPLI analizlerinde ise istatistiksel olarak anlamlı bir değişiklik kaydedilmedi. Klinik olarak değerlendirildiğinde ise propofol uygulaması sonrasında hiçbir hayvanda pankreatitis bulgusuna rastlanmadı. Sonuç olarak bir saat süre ile uygulanan propofolun, serum trigliserid düzeyini yükselttiği, ancak pankreas üzerine etkisi değerlendirildiğinde klinik açıdan güvenli olduğu kanısına varılmıştır.Anahtar sözcükler: Anestezi, köpek, pankreatitis, propofol.The effects of short term propofol administration on pancreatitis formation in dogs * Summary: Even the incidence of a drug-induced pancreatitis is rare there are more than 85 different drugs have been reported that induces pancreatitis. FDA have been reported that propofol administration resulted in pancreatitis in 25 human cases. Even though there are several reports pointed out an increase in blood lipid and triglyceride levels after propofol administration, there are no studies investigated the possible association between the use of propofol and consequently occuring pancreatitis in veterinary medicine. The aim of this study was to evaluate the possible side-effects of propofol administration on pancreatic tissue in dogs. Twenty healty dogs were anesthetized for at least one hour. Bloods were collected to evaluate the serum amylase, lipase, ALP, AST, GGT, cPLI, cholesterol, triglyceride, Ca and glucose levels before and after propofol administration, during recovery period and after 4th and 24th hour. It was recorded that the serum glucose, calcium and triglyceride levels were increased during anesthesia, on the contrary serum amylase, lipase, ALP, AST, GGT, and cholesterol levels were decreased. The alterations in cPLI was insignificant. Clinical evaluation is not revealed any evidence of pancreatitis in neither of the animals. As a result, it was concluded that although the triglyceride levels were found to be elevated during propofol administration, it did not cause any clinical manifestations regarding pancreatic activity.

show abstract

Propofol: Application in veterinary sedation and anesthesia

Cited by 50 publications

References 28 publications

Quantitative electroencephalographic findings in beagles anaesthetized with propofol

Quantitative electroencephalographic findings in beagles anaesthetized with propofol

Comparison of Propofol-Remifentanil and Propofol-Fentanyl Anesthesia During Ovariohysterectomy in Dogs

Köpeklerde kısa süreli uygulanan propofolün pankreatitis oluşumuna etkisi

Contact Info

Product

Resources

About