Propofol enhanced the cell sensitivity to paclitaxel (PTX) in prostatic cancer (PC) through modulation of HOTAIR

Yang, Xuesong; Qin, Jiao; Gong, Chunyu; Yang, Jing

doi:10.1007/s13258-021-01093-0

Cited by 9 publications

(10 citation statements)

References 28 publications

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“…Frontiers in Bioengineering and Biotechnology | www.frontiersin.org November 2021 | Volume 9 | Article 706536 9 Shi et al, 2021;Yang et al, 2021). Studies have proven that miRNAs and their regulatory genes play important roles in the development of PCa (Wei et al, 2007;Deng et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

“…Many studies have shown that differentially expressed proteins in PCa affect its development and that most of these proteins are regulated at the transcriptional level and in turn regulate related signaling pathways ( Nam et al, 2021 ; Papachristodoulou et al, 2021 ; Shi et al, 2021 ; Yang et al, 2021 ). Studies have proven that miRNAs and their regulatory genes play important roles in the development of PCa ( Wei et al, 2007 ; Deng et al, 2013 ).…”

Section: Discussionmentioning

confidence: 99%

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Folic Acid–Modified miR-491-5p–Loaded ZIF-8 Nanoparticles Inhibit Castration-Resistant Prostate Cancer by Regulating the Expression of EPHX1

Liu

et al. 2021

Front. Bioeng. Biotechnol.

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Epoxide hydrolase 1 (EPHX1) has been reported to be related to the development of several tumors. However, the regulation of castration-resistant prostate cancer (CRPC) development by EPHX1 has not been reported. We used proteomic technology and found that the EPHX1 protein was highly expressed in CRPC tissues and the CRPC cell line C4-2. We performed screening and found that EPHX1 is a direct target of miR-491-5p. High miR-491-5p expression significantly reduced the EPHX1 level in C4-2 cells and inhibited C4-2 cell proliferation and migration. Zeolite imidazolate framework-8 (ZIF-8) has good thermal stability, a simple synthesis method, tumor site stability, and specific acid responsiveness. We synthesized ZIF-8 nanodrug vectors to deliver miR-491-5p into C4-2 cells. After loading miR-491-5p into ZIF-8, we modified the ZIF-8 surface with folic acid (FA) as the target group (FA@ZIF-8). Our synthesized nanodrug carrier showed less cytotoxicity to C4-2 cells even at 200 μg/ml. Modified FA could increase the efficiency of nanomaterial entry into C4-2 cells. FA@miR-491-5p@ZIF-8 could stably release miR-491-5p for a long period in both phosphate-buffered saline (pH 7.4) and acetate buffer (pH 4.8), and miR-491-5p was released faster at the beginning of the experiment in acetate buffer (pH 4.8). FA@miR-491-5p@ZIF-8 significantly reduced C4-2 cell proliferation and migration, and FA@miR-491-5p@ZIF-8 had a better effect than miR-491-5p alone. In vivo, FA@miR-491-5p@ZIF-8 significantly inhibited CRPC growth in nude mice. Overall, we verified that miR-491-4p regulated CRPC development by targeting EPHX1. The drug nanocarrier FA@miR-491-5p@ZIF-8 not only significantly reduced C4-2 CRPC cell proliferation and migration but also significantly inhibited CRPC growth. Our research provides a theoretical basis for treatment and treatment strategies for CRPC.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Folic Acid–Modified miR-491-5p–Loaded ZIF-8 Nanoparticles Inhibit Castration-Resistant Prostate Cancer by Regulating the Expression of EPHX1

Liu

et al. 2021

Front. Bioeng. Biotechnol.

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“…HOTAIR downregulation using siRNA weakened trastuzumab resistance through activating the MEK/MAPK and PI3K/AKT/mTOR pathways [65]. In prostate cancer, propofol strengthened PTX sensitivity by regulating HOTAIR-mediated EMT [66]. In GBM, HOTAIR knockdown suppressed tumor growth, migration, and invasion and EMT, whereas exosomal HOTAIR accelerated TMZ resistance by the miR-519a-3p/RRM1 pathway [67].…”

Section: Hotair Enhances Emtmentioning

confidence: 99%

Functions and underlying mechanisms of lncRNA HOTAIR in cancer chemotherapy resistance

Zhu

Wang

et al. 2022

Cell Death Discov.

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Chemotherapy has been one of the most important treatments for advanced cancer in recent decades. Although the sensitivity rate of initial chemotherapy is high, patients with chemotherapy resistant tumors, experience tumor recurrence. In recent years, many studies have shown that homeobox transcript antisense intergenic RNA (HOTAIR) is involved in many pathological processes including carcinogenesis. The abnormal regulation of a variety of cell functions by HOTAIR, such as apoptosis, the cell cycle, epithelial-mesenchymal transition, autophagy, self-renewal, and metabolism, is associated with chemotherapy resistance. Therefore, there is an urgent need to understand the biology and mechanism underlying the role of HOTAIR in tumor behavior and its potential as a biomarker for predicting the effect of chemotherapy. In this manuscript, we review the mechanisms underlying HOTAIR-related drug resistance and discuss the limitations of current knowledge and propose potential future directions.

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“…Paclitaxel (PTX) and docetaxel, which are taxane-based chemotherapy drugs, boost the polymerization of microtubule proteins and prevent their depolymerization in order to block the mitotic process and induce apoptosis, which are used together with other anti-cancer drugs in the treatment of a variety of tumors. Yang et al (2021) showed that propofol enhanced the sensitivity of prostate cancer cells to PTX by reducing the expression of HOTAIR, which promoted apoptosis of cancer cells. In prostate cancer, propofol also reversed hypoxia-induced docetaxel resistance by inhibiting HIF-1α to prevent epithelial-mesenchymal transition (Qian et al, 2018).…”

Section: Regulation Of Drug Resistancementioning

confidence: 99%

An intravenous anesthetic drug-propofol, influences the biological characteristics of malignant tumors and reshapes the tumor microenvironment: A narrative literature review

Zhou

Shao

et al. 2022

Front. Pharmacol.

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Malignant tumors are the second leading cause of death worldwide. This is a public health concern that negatively impacts human health and poses a threat to the safety of life. Although there are several treatment approaches for malignant tumors, surgical resection remains the primary and direct treatment for malignant solid tumors. Anesthesia is an integral part of the operation process. Different anesthesia techniques and drugs have different effects on the operation and the postoperative prognosis. Propofol is an intravenous anesthetic that is commonly used in surgery. A substantial number of studies have shown that propofol participates in the pathophysiological process related to malignant tumors and affects the occurrence and development of malignant tumors, including anti-tumor effect, pro-tumor effect, and regulation of drug resistance. Propofol can also reshape the tumor microenvironment, including anti-angiogenesis, regulation of immunity, reduction of inflammation and remodeling of the extracellular matrix. Furthermore, most clinical studies have also indicated that propofol may contribute to a better postoperative outcome in some malignant tumor surgeries. Therefore, the author reviewed the chemical properties, pharmacokinetics, clinical application and limitations, mechanism of influencing the biological characteristics of malignant tumors and reshaping the tumor microenvironment, studies of propofol in animal tumor models and its relationship with postoperative prognosis of propofol in combination with the relevant literature in recent years, to lay a foundation for further study on the correlation between propofol and malignant tumor and provide theoretical guidance for the selection of anesthetics in malignant tumor surgery.

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Propofol enhanced the cell sensitivity to paclitaxel (PTX) in prostatic cancer (PC) through modulation of HOTAIR

Cited by 9 publications

References 28 publications

Folic Acid–Modified miR-491-5p–Loaded ZIF-8 Nanoparticles Inhibit Castration-Resistant Prostate Cancer by Regulating the Expression of EPHX1

Folic Acid–Modified miR-491-5p–Loaded ZIF-8 Nanoparticles Inhibit Castration-Resistant Prostate Cancer by Regulating the Expression of EPHX1

Functions and underlying mechanisms of lncRNA HOTAIR in cancer chemotherapy resistance

An intravenous anesthetic drug-propofol, influences the biological characteristics of malignant tumors and reshapes the tumor microenvironment: A narrative literature review

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