Propofol‐induced irreversible hair depigmentation: a case report

Ricci, Francesco; Lunghi, Franco; Simone, Clara De; Peris, Ketty

doi:10.1111/ijd.13594

Cited by 3 publications

(2 citation statements)

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“…Sixty-seven articles were published in English, six in Spanish, two in Dutch, one in Korean, and one in Turkish. The mentioned publications documented 95 cases of propofol-associated discoloration (and no case of fospropofol-associated discoloration): 54 (57%) with a green urine discoloration [2,, 32 (34%) with a pink-cloudy urine discoloration [3,[60][61][62][63][64][65][66][67][68][69][70][71][72][73][74][75][76][77][78], and nine (9.5%) with a non-urinary green discoloration [46,[79][80][81][82][83][84][85][86]. Completeness of reporting was satisfactory in 33 (35%), good in 35 (37%), and excellent in 27 (28%) cases.…”

Section: Search Outputs -Completeness Of Reportingmentioning

confidence: 99%

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Propofol-Associated Urine Discoloration: Systematic Literature Review

Lasica,

Cortesi,

Milani

et al. 2023

Pharmacology

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Introduction: Propofol occasionally induces a green or pink-cloudy urine discoloration. A lesser-known effect is green discoloration of hair, milk, liver, or stool. We aimed to gain insight into the features of these disturbances. Methods: The terms (“propofol” OR “fospropofol”) AND (“green” OR “pink” OR “cloudy” OR “pink-cloudy”) were searched in Excerpta Medica, MEDLINE/PubMed®, and Web of Sciences databases, with no language limit, from inception up to February 2023 (CRD4202236804). Articles reporting individually documented cases were retained, and data were extracted using a checklist. Results: Seventy-seven original reports documented 95 cases (including 13 subjects ≤18 years of age). Completeness of reporting was satisfactory in 33, good in 35, and excellent in 27 cases. Propofol-associated green urine discoloration was observed in 54 patients. In most instances (n = 21, 39%), propofol was given for ≥24 h. Sometimes, however, the urine discoloration developed after propofol for ≤3 h (n = 12, 22%). Propofol-associated urine discoloration was usually observed during the administration of this agent, but it was at times (n = 11) first recognized ≥3 h after propofol discontinuation. The duration of green urine discoloration was usually ≤24 h after stopping propofol. Propofol-associated green urine discoloration was never associated with worsening kidney function. A pink-cloudy urine discoloration was observed in 32 subjects with an acidic urine pH and increased uric acid excretion given propofol for ≤24 h. A stage I acute kidney injury was observed in 2 cases (6.3%) of propofol-associated pink-cloudy urine discoloration. Nine cases of non-urinary green discoloration were observed: hair (n = 4), breast milk (n = 1), liver (n = 1), stool (n = 1). Conclusion: Propofol is sometimes associated with a green (benign) or pink-cloudy (occasionally associated with mild acute kidney injury) urine discoloration. Rarely, non-urinary green discoloration has been reported.

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Section: Search Outputs -Completeness Of Reportingmentioning

confidence: 99%

“…A non-urinary green discoloration was observed in 9 subjects, 1.8–60 (median 37) years of age: green hair [49, 79, 83, 85] in four, green breast milk in three [82, 84, 85], and green liver [80] or stool [81] in each 1 case. A green urine discoloration preceded the non-urinary discoloration in only 1 case [49].…”

Section: Patients Characteristicsmentioning

confidence: 99%