Propofol-Induced Vasodilation in Human Internal Mammary Artery: Role of Potassium Channels

Doğan, Muhammed Fatih; Arslan, Seyfullah Oktay; Yıldız, Oğuzhan; Kurtoğlu, Murat; Parlar, Ali İhsan

doi:10.1053/j.jvca.2018.12.015

Cited by 13 publications

(16 citation statements)

References 47 publications

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“…Several studies demonstrated that testosterone and taurine‐induced vasodilation may occur via activation of BK Ca in the human radial artery and the internal mammary artery . It has been shown that the vasodilator effect of propofol on the human umbilical vessels and the internal mammary artery is related to BK Ca . Propofol also relaxed the mesenteric arterioles via BK Ca activation in rat .…”

Section: Basic Properties Of Potassium Channelsmentioning

confidence: 99%

Potassium channels in vascular smooth muscle: a pathophysiological and pharmacological perspective

Doğan

Yıldız

Arslan

et al. 2019

Fundamemntal Clinical Pharma

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Potassium (K+) ion channel activity is an important determinant of vascular tone by regulating cell membrane potential (MP). Activation of K+ channels leads to membrane hyperpolarization and subsequently vasodilatation, while inhibition of the channels causes membrane depolarization and then vasoconstriction. So far five distinct types of K+ channels have been identified in vascular smooth muscle cells (VSMCs): Ca+2‐activated K+ channels (BKCa), voltage‐dependent K+ channels (KV), ATP‐sensitive K+ channels (KATP), inward rectifier K+ channels (Kir), and tandem two‐pore K+ channels (K2P). The activity and expression of vascular K+ channels are changed during major vascular diseases such as hypertension, pulmonary hypertension, hypercholesterolemia, atherosclerosis, and diabetes mellitus. The defective function of K+ channels is commonly associated with impaired vascular responses and is likely to become as a result of changes in K+ channels during vascular diseases. Increased K+ channel function and expression may also help to compensate for increased abnormal vascular tone. There are many pharmacological and genotypic studies which were carried out on the subtypes of K+ channels expressed in variable amounts in different vascular beds. Modulation of K+ channel activity by molecular approaches and selective drug development may be a novel treatment modality for vascular dysfunction in the future. This review presents the basic properties, physiological functions, pathophysiological, and pharmacological roles of the five major classes of K+ channels that have been determined in VSMCs.

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Section: Basic Properties Of Potassium Channelsmentioning

confidence: 99%

Potassium channels in vascular smooth muscle: a pathophysiological and pharmacological perspective

Doğan

Yıldız

Arslan

et al. 2019

Fundamemntal Clinical Pharma

Self Cite

View full text Add to dashboard Cite

show abstract

“…IN THIS ISSUE of the Journal of Cardiovascular and Thoracic Anesthesia, Dogan et al present a study titled "Propofol-Induced Vasodilation in Human Internal Mammary Artery: Role of Potassium Channels" aimed at identifying the mechanism involved in propofol-mediated vasodilation of the internal mammary artery (IMA) in vitro. 1 The authors conclude that propofol use in coronary artery bypass graft (CABG) surgery may have favorable vasodilator effects to overcome perioperative vasospasm of the IMA.…”

mentioning

confidence: 99%

“…The study methods used IMA parts discarded from patients during CABG surgery. 1 IMA contraction then was induced by various vasoconstrictors (potassium chloride, phenylephrine, 5-hydroxytryptamine, and calcium chloride), and the antagonistic effect of cumulative concentrations of propofol was assessed in the presence of various potassium receptor, nitric oxide synthase, and cyclooxygenase inhibitors. Results showed that propofol-induced vasodilation was concentration dependent, endothelium independent, and associated with propofol-induced activation of large conductance calcium (Ca 2+ )-activated potassium (K + ) channels (BK ca ).…”

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confidence: 99%

“…Results showed that propofol-induced vasodilation was concentration dependent, endothelium independent, and associated with propofol-induced activation of large conductance calcium (Ca 2+ )-activated potassium (K + ) channels (BK ca ). 1 The authors thoughtfully designed a protocol aimed at identifying key mechanisms involved in IMA propofol-induced vasodilation. With that said, additional research is needed to determine the clinical relevance of these novel findings.…”

mentioning

confidence: 99%

“…In summary, Dogan et al demonstrated in vitro IMA vasodilation in a concentration-dependent, endotheliumindependent manner secondary to activation of large conductance BK ca channels in smooth muscle with the use of propofol. 1 IMA spasm can occur throughout the perioperative period, and severe refractory spasm can lead to significant morbidity and mortality. Exploration of new techniques for the pharmacologic management of spasm is valid, and the authors did investigate a relatively novel treatment approach.…”

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confidence: 99%

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