Propofol infusion syndrome: A lethal condition in critically injured patients eliminated by a simple screening protocol

Propofol infusion syndrome

“…11 This in turn causes diffuse cellular hypoxia and muscle necrosis. 11 This in turn causes diffuse cellular hypoxia and muscle necrosis.…”

“…11 This in turn causes diffuse cellular hypoxia and muscle necrosis. 11 PRIS is considered a pharmacogenetic phenomenon, suggesting that some patients may have a specific susceptibility to the disease. 11 PRIS is considered a pharmacogenetic phenomenon, suggesting that some patients may have a specific susceptibility to the disease.…”

“…13 A mitochondrial defect may predispose some patients to PRIS. 11 Additionally, propofol' s lipid emulsion is thought to cause accumulation of free fatty acids, leading to dysrhythmia. This is referred to as the "coved type" Brugada pattern.…”

“…11 The lack of a standardized screening tool for PRIS presents a challenge because many of the presenting signs (such as metabolic acidosis) are common in critically ill patients or are adverse reactions to propofol, such as bradycardia. A screening protocol based on creatine kinase and lactic acid levels has been studied in a single-center trial, but external validity hasn't been established.…”

“…11 Interdisciplinary collaboration among nurses, healthcare providers, and pharmacists is essential for the prompt recognition and treatment of PRIS. propofol who have risk factors, including high doses (more than 4 mg/kg/hr), prolonged use (longer than 48 hr), critical illness, concomitant use of vasopressors or steroids, low carbohydrate intake, and relatively young age (less than age 55), hold a high index of suspicion of PRIS.…”