Propofol infusion syndrome

Chen, Leon; Lim, Fidelindo

doi:10.1097/01.nurse.0000456376.94907.11

Cited by 3 publications

(1 citation statement)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interestingly, despite the fact that previously several cases have shown the fatality of propofol given in a dose higher than 4 mg/kg/h over more than 48 h which is the maximal dosage to be supported strongly by the international recommendations, higher doses have still been given in recent reports (Deters et al, Savard et al, and Mayette et al in 2013 [ 7 , 9 , 10 ] and Chen and Lim in 2014 [ 17 ]).…”

Section: Resultsmentioning

confidence: 99%

Propofol Infusion Syndrome in Refractory Status Epilepticus: A Case Report and Topical Review

Walli

Poulsen

Dam

et al. 2016

Case Reports in Emergency Medicine

View full text Add to dashboard Cite

Propofol infusion syndrome (PRIS) is a fatal complication when doses of propofol administration exceed 4 mg/kg/h for more than 48 hours. Propofol overdosage is not uncommon in patients with refractory status epilepticus (RSE). We describe a case of refractory status epilepticus complicated by propofol infusion syndrome and collect from 5 databases all reports of refractory status epilepticus cases that were treated by propofol and developed the syndrome and outline whether refractory status epilepticus treatment with propofol is standardized according to international recommendations, compare it with alternative medications, and discuss how this syndrome can be treated and prevented. A total of 21 patients who developed this syndrome reported arrhythmia in all cases (100%), rhabdomyolysis in 9 cases (42%), lactic acidosis in 13 cases (62%), renal failure in 8 cases (38%), lipemia in 7 cases (33%), and elevated hepatic enzymes in 6 cases (28%). 13 patients died (66%). Propofol is still given in a dosage higher than what is internationally recommended, and new treatment modalities such as renal replacement therapy, blood exchange, and extracorporeal membrane oxygenation seem to be promising. In conclusion, propofol should be carefully titrated, the maximal infusion rate needs to be reassessed, and combination of different sedative agents may be considered.

show abstract

Section: Resultsmentioning

confidence: 99%

Propofol Infusion Syndrome in Refractory Status Epilepticus: A Case Report and Topical Review

Walli

Poulsen

Dam

et al. 2016

Case Reports in Emergency Medicine

View full text Add to dashboard Cite

show abstract

Propofol

2015

Reactions Weekly

View full text Add to dashboard Cite

Hemodynamic Effects of Ketamine Infusion in the Intensive Care Unit for Maintenance Sedation Compared With Propofol and Midazolam: A Retrospective Cohort Study

Khatib¹,

Roelofsz²,

Singh³

et al. 2022

TOJ

View full text Add to dashboard Cite

Background: Sedation and analgesia in the intensive care unit (ICU) are major clinical challenges, and several continuous infusion medications have been used for these purposes. The use of these sedative medications has been associated with hemodynamic effects that complicate the patient's critical illness. Continuous ketamine infusion is an emerging sedative option that has been used more frequently in the ICU since 2017. The purpose of this study was to characterize the hemodynamic differences between 3 continuous sedative infusions: ketamine, propofol, and midazolam. Methods: For this single-center retrospective cohort study, we collected data for patients hospitalized between January 2015 and April 2020 at Saint Luke's Health System in Kansas City, Missouri. Adult patients in the ICU requiring a norepinephrine infusion and sedation were included. The change in norepinephrine requirement from baseline at 1 hour was the primary outcome. The change in vasopressor requirement at 3 and 30 hours after initiation of the infusion was also tabulated. Results: Sixty-eight critically ill patients with several types of shock requiring vasopressor support with norepinephrine were enrolled in our study. Patients who received ketamine had an increase in norepinephrine requirement compared to midazolam and propofol, although this difference was not statistically significant. Conclusion:In our study, continuous ketamine infusion did not reveal a statistically significant favorable hemodynamic effect compared with propofol and midazolam because of the small sample size. A trend toward an unfavorable hemodynamic effect is not expected, but large randomized trials are needed to further evaluate the hemodynamic effects of continuous ketamine infusion in the ICU.

show abstract

Propofol infusion syndrome

Cited by 3 publications

References 11 publications

Propofol Infusion Syndrome in Refractory Status Epilepticus: A Case Report and Topical Review

Propofol Infusion Syndrome in Refractory Status Epilepticus: A Case Report and Topical Review

Propofol

Hemodynamic Effects of Ketamine Infusion in the Intensive Care Unit for Maintenance Sedation Compared With Propofol and Midazolam: A Retrospective Cohort Study

Contact Info

Product

Resources

About