Propofol Prevents Lung Injury Following Intestinal Ischemia-Reperfusion

The protective effects of curcumin on intestine and remote organs against mesenteric ischemia/reperfusion injury

“…The amount of ROS produced is under the control exerted by antioxidant defense mechanisms (19). An increase in MDA levels, as a marker of lipid peroxidation, was observed after 60 min reperfusion in rats with the SMA occluded for 60 or 45 min (5,20). In this study, MDA levels of serum increased after 60 min reperfusion in rats with the SMA occluded for 30 min, supporting the oxidative stress.…”

The Effects of Short-Term Propofol and Dexmedetomidine on Lung Mechanics, Histology, and Biological Markers in Experimental Obesity

“…Propofol (PRO) and dexmedetomidine (DEX) have a favorable pharmacokinetic profile for anesthesia and sedation and are used for surgical procedures and long-term sedation in intensive care units in the obese population. [3][4][5] In lean animals, PRO decreases airway resistance and lung inflammation in experimental acute lung injury induced by endotoxin, 6,7 ischemia-reperfusion, 8 or oleic acid. 9 Similarly, in lean human subjects, PRO improves lung mechanics, 10 reduces inflammation, 11 and modulates oxidative stress.…”

Protective effects of montelukast and Hypericum perforatum against intestinal ischemia-reperfusion injury in hamsters

“…The authors did not find evidence of any preventive effects of N-acetylcysteine on I/R injury by means of histopathologic findings. Other studies showed increased MDA levels after 60 min of reperfusion in rats following 60 or 45 min of SMA occlusion (23,24). Önder et al reported a significant increase in serum MDA levels in a mesenteric I/R injury model of 30 min of ischemia followed by a 1-h reperfusion period (25).…”