Propolis Action in Controlling Activated T Cell Producing TNF-alfa and IFN-gamma in Diabetic Mice

Ningsih, Febby Nurdiya; Rifa’i, Muhaimin

doi:10.25002/tji.2017.575

Cited by 4 publications

(3 citation statements)

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“…1,2 Based on research data, significant differences exist between treatment groups. The highest mean of osteoclasts number occurred in group V (BBG + PEG on day 14) and the lowest occurred in group VII (propolis extract + PEG on day 14). While the highest mean of osteoblasts number occurred in group VIII (Propolis extract + BBG + PEG on day 30), and the lowest mean occurred in group I (Control on day 14).…”

Section: Discussionmentioning

confidence: 91%

“…The decrease of oxidative pressure level suppresses the activation of nuclear factor kappa beta (NF-κB) that acts as a transcription factor for the coding of pro-inflammatory cytokine genes, including TNF-α and IFN-γ so as to reduce inflammation. 7,14 Caffeic acid phenetyl ester (CAPE) is an antioxidant that can inhibit excessive oxidative reactions caused by inflammatory reactions and metabolic processes of cell injury. As an anti-inflammatory, CAPE acts to inhibit phospholipase in the arachidonic acid cascade, so that it does not release prostaglandins and leukotrin and inhibits the process of lipoxygenase (LOX) and cycloxygenase (COX), which play a role in inflammatory metabolic pathways.…”

Section: Discussionmentioning

confidence: 99%

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The effect of propolis extract and bovine bone graft combination on the number of osteoclast and osteoblast as an effort to preserve post-extraction socket (on Cavia cobaya)

2020

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Background: Post-extraction alveolar bone height and width never reach the same dimensions as before extraction. A combination of propolis extracts and bovine bone graft (BBG) that are anti-inflammatory, antioxidant, osteoinductive and osteconductive is expected to improve bone regeneration. Purpose: Knowing the effect of the combination of propolis extracts and BBG on the number of osteoclast and osteoblast as an effort to preserve the socket after extraction of Cavia cobaya teeth. Methods: 56 Cavia cobaya was divided into eight groups: the lower left incisor was extracted, and the socket was filled with 2% poly ethylene glycol (PEG), propolis extract+PEG, BBG+PEG, and a combination of propolis extract+BBG+PEG. The incisors socket of animals models were executed on the 14th and 30th days. Using HE for histopathological examination, the number of osteoclasts and osteoblasts were counted with a 400x magnification light microscope with nine visual fields. The data were analysed via one-way ANOVA and Tukey HSD tests. Results: The highest mean number of osteoclasts occurred in the BBG+PEG 14th day group and the lowest occurred in the propolis extract+BBG+PEG 14th day group. The highest mean number of osteoblasts occurred in the propolis + BBG + PEG combination 30th day group, the lowest occurred in the control group (PEG) on the 14th day. Conclusion: The 2% combination of propolis extracts and BBG effectively reduces the osteoclast number and increases the osteoblast number in preserving the socket after extracting Cavia cobaya teeth.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

The effect of propolis extract and bovine bone graft combination on the number of osteoclast and osteoblast as an effort to preserve post-extraction socket (on Cavia cobaya)

2020

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“…7 Pemberian propolis dengan dosis 100 dan 200 mg/kg dapat menekan ekspresi sitokin proinflamasi seperti menurunkan ekspresi TNF-α dan IFN-γ. 8 Berdasarkan uraian tersebut, tujuan penelitian ini untuk mengetahui pengaruh pemberian propolis sebagai anti inflamasi terhadap sitokin IL-6 penderita Diabetes Melitus Tipe 2.…”

Section: Pendahuluanunclassified

Pengaruh Propolis Terhadap Il-6 Pada Diabetes Melitus Tipe 2: <i>A Literature Review</i>

Shafriani¹

2021

HMJ

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Type-2 diabetes is a metabolic disease characterized by an increase in blood sugar levels due to decreased insulin secretion by pancreatic beta cells, or inappropriate insulin action. The pathophysiology of type-2 diabetes is related to inflammatory mechanisms caused by an increase in proinflammatory cytokines such as IL-6. Propolis has an anti-inflammatory role that can influence type 2 diabetes. To determine the effect of propolis as an anti-inflammatory to the IL-6 cytokines in type 2 Diabetes Mellitus A Literature review by searching electronic databases on Pubmed, ProQuest, and Google Scholar with the keywords "propolis or bee propolis and IL-6 levels or interleukin-6 levels and diabetes type-2 or type-2 diabetes" published in 2010-2020. Based on the search results, 9 journals were found. These articles consist of 5 experimental articles and 4 RCT articles. Five databases reported a decrease in IL-6 levels and three journals stated that there was an increase in IL-6 levels in the type-2 diabetes group after being given propolis. One journal reported no significant difference. Variations in propolis administration and time in IL-6 measurements affected the tendency to decrease IL-6 levels in type 2 diabetes patients. The active components in propolis were influenced by differences in plant resources, collection season, bee species, and solvents used in the extraction. IL-6 levels in the type-2 diabetes group tended to decrease after propolis administration compared to the type-2 diabetes group without propolis administration. IL-6 levels in the type-2 diabetes group increased after propolis administration because IL-6 helps improve chronic inflammation associated with type-2 diabetes.

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Ex vivo immunomodulatory effect of ethanolic extract of propolis during Celiac Disease: involvement of nitric oxide pathway

et al. 2018

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Celiac Disease (CeD) is a chronic immune-mediated enteropathy, in which dietary gluten induces an inflammatory reaction, predominantly in the duodenum. Propolis is a resinous hive product, collected by honeybees from various plant sources. Propolis is well-known for its anti-inflammatory, anti-oxidant and immunomodulatory effects, due to its major compounds, polyphenols and flavonoids. The aim of our study was to assess the ex vivo effect of ethanolic extract of propolis (EEP) upon the activity and expression of iNOS, along with IFN-γ and IL-10 production in Algerian Celiac patients. In this context, PBMCs isolated from peripheral blood of Celiac patients and healthy controls were cultured with different concentrations of EEP. NO production was measured using the Griess method, whereas quantitation of IFN-γ and IL-10 levels was performed by ELISA. Inducible nitric oxide synthase (iNOS) expression, NFκB and pSTAT-3 activity were analyzed by immunofluorescence assay. Our results showed that PBMCs from Celiac patients produced high levels of NO and IFN-γ compared with healthy controls (HC). Interestingly, EEP reduced significantly, NO and IFN-γ levels and significantly increased IL-10 levels at a concentration of 50 µg/mL. Importantly, EEP downmodulated the iNOS expression as well as the activity of NFκB and pSTAT-3 transcription factors. Altogether, our results highlight the immunomodulatory effect of propolis on NO pathway and on pro-inflammatory cytokines. Therefore, we suggest that propolis may constitute a potential candidate to modulate inflammation during Celiac Disease and has a potential therapeutic value.

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Propolis Action in Controlling Activated T Cell Producing TNF-alfa and IFN-gamma in Diabetic Mice

Cited by 4 publications

References 0 publications

The effect of propolis extract and bovine bone graft combination on the number of osteoclast and osteoblast as an effort to preserve post-extraction socket (on Cavia cobaya)

The effect of propolis extract and bovine bone graft combination on the number of osteoclast and osteoblast as an effort to preserve post-extraction socket (on Cavia cobaya)

Pengaruh Propolis Terhadap Il-6 Pada Diabetes Melitus Tipe 2: <i>A Literature Review</i>

Ex vivo immunomodulatory effect of ethanolic extract of propolis during Celiac Disease: involvement of nitric oxide pathway

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