Propolis nanoparticles modulate the inflammatory and apoptotic pathways in carbon tetrachloride‐induced liver fibrosis and nephropathy in rats

Izzularab, Batoul Mohamed; Megeed, Mervat; Yehia, Mona

doi:10.1002/tox.23010

Cited by 13 publications

(17 citation statements)

References 62 publications

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“…Untreated diabetic rats had a significant increase in glomerular basement membrane thickness [114]. Propolis also reduced the CCl 4 -induced apoptosis of renal cells by downregulating the caspase-9 gene and upregulating Bcl-2 gene expression [119].…”

Section: Chronic Kidney Diseasementioning

confidence: 93%

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Propolis in Metabolic Syndrome and Its Associated Chronic Diseases: A Narrative Review

et al. 2021

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Propolis is a resinous product collected by bees from plants to protect and maintain the homeostasis of their hives. Propolis has been used therapeutically by humans for centuries. This review article attempts to analyze the potential use of propolis in metabolic syndrome (MetS) and its associated chronic diseases. MetS and its chronic diseases were shown to be involved in at least seven out of the top 10 causes of death in 2019. Patients with MetS are also at a heightened risk of severe morbidity and mortality in the present COVID-19 pandemic. Propolis with its antioxidant and anti-inflammatory properties is potentially useful in ameliorating the symptoms of MetS and its associated chronic diseases. The aim of this article is to provide a comprehensive review on propolis and its therapeutic benefit in MetS and its chronic diseases, with an emphasis on in vitro and in vivo studies, as well as human clinical trials. Moreover, the molecular and biochemical mechanisms of action of propolis are also discussed. Propolis inhibits the development and manifestation of MetS and its chronic diseases by inhibiting of the expression and interaction of advanced glycation end products (AGEs) and their receptors (RAGEs), inhibiting pro-inflammatory signaling cascades, and promoting the cellular antioxidant systems.

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Section: Chronic Kidney Diseasementioning

confidence: 93%

“…[ 103,[114][115][116][117][118][119][120][121][122][123][124] human clinical trials Reduction in proteinuria, oxidative stress, and inflammatory markers. [125,126] Non-alcoholic fatty liver disease in-vitro and in-vivo Reduction in inflammatory markers and hepatic steatosis severity.…”

Section: Hypertension In Vivomentioning

confidence: 99%

Propolis in Metabolic Syndrome and Its Associated Chronic Diseases: A Narrative Review

et al. 2021

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“…Therapies developed along the principles of synthetic medicine are often limited in efficacy, carry the risk of adverse effects and are often expensive, especially for the developing world. Therefore, treating liver diseases with plant-derived compounds has attracted research and clinical interest [ 84 , 85 , 86 ].…”

Section: Propolis Bioactivitiesmentioning

confidence: 99%

Experimental Evidence for Therapeutic Potentials of Propolis

et al. 2021

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Propolis is produced by honeybees from materials collected from plants they visit. It is a resinous material having mixtures of wax and bee enzymes. Propolis is also known as bee glue and used by bees as a building material in their hives, for blocking holes and cracks, repairing the combs and strengthening their thin borders. It has been extensively used since ancient times for different purposes in traditional human healthcare practices. The quality and composition of propolis depend on its geographic location, climatic zone and local flora. The New Zealand and Brazilian green propolis are the two main kinds that have been extensively studied in recent years. Their bioactive components have been found to possess a variety of therapeutic potentials. It was found that Brazilian green propolis improves the cognitive functions of mild cognitive impairments in patients living at high altitude and protects them from neurodegenerative damage through its antioxidant properties. It possesses artepillin C (ARC) as the key component, also known to possess anticancer potential. The New Zealand propolis contains caffeic acid phenethyl ester (CAPE) as the main bioactive with multiple therapeutic potentials. Our lab performed in vitro and in vivo assays on the extracts prepared from New Zealand and Brazilian propolis and their active ingredients. We provided experimental evidence that these extracts possess anticancer, antistress and hypoxia-modulating activities. Furthermore, their conjugation with γCD proved to be more effective. In the present review, we portray the experimental evidence showing that propolis has the potential to be a candidate drug for different ailments and improve the quality of life.

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“…With extensive use and repeated exposure to toxic chemicals in everyday life, the human body absorbs exotoxins through drinking, the skin, and respiration [1], those toxins get into the bloodstream, causing oxidative stress [2]. Carbon tetrachloride appears as a colorless and volatile liquid, the hepatotoxic effect of CCl4 is largely due to its active metabolites, trichloromethyl free radicals such as CCl3 and CCl3OO− [3]. Subsequent damage caused by CCl4 has been linked to many mechanisms, including the disruption of redox equilibrium and the induction of programmed cell death and liver cirrhosis in experimental animals and humans [4].…”

Section: Introductionmentioning

confidence: 99%

Effect of spinach-derived glutathione against carbon tetrachloride-induced stress in rats

Abdulrazak¹,

Jameel

2022

FFHD

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Background: Increased consumption of natural antioxidants found in vegetables and fruits has been linked to a lower risk of disease caused by oxidative stress.Objective: The current study's focus was to compare the antioxidant properties of synthetic glutathione and glutathione derived from spinach against CCl4-induced stress in female albino rats. Materials and Methods: Cold chloroform extraction was used to prepare the spinach leaf extract. Glutathione was then extracted from the spinach leaf extract using preparative HPLC afterward when the concentration of glutathione was measured in the extract. Biological preventive and therapeutic experiments were conducted, where laboratory rats were divided into 6 groups, the first group G1 (positive control group), the second group G2 (negative control group), the third group G3 preventive experiment 1 (group glutathione extracted from spinach + CCl4), the fourth group G4 therapeutic experiment 1 (Group CCl4+ Glutathione extracted from spinach), the fifth group G5 Preventive experiment 2 (Group of synthetic glutathione + CCl4), the sixth group G6 therapeutic experiment 2 (Group CCl4+ Glutathione extracted from spinach). Results: Treatment of rats with spinach-derived synthetic glutathione, before or after they were given CCl4 subcutaneous, improved the values of parameters near to normal levels in the positive control animals in groups treated with spinach-derived glutathione (G3 and G4) compared to treatment with synthetic glutathione (G5 and G6). Administration of milk with glutathione derived from Iraqi spinach leaves exhibited favorable effects on oxidative stress, greatly enhanced the antioxidant system, and protected rats from liver damage brought on by carbon tetrachloride compared to milk with synthetic glutathione. Keywords: Iraqi spinach, Functional food, Natural antioxidant, Oxidative stress, synthetic glutathione.

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Propolis nanoparticles modulate the inflammatory and apoptotic pathways in carbon tetrachloride‐induced liver fibrosis and nephropathy in rats

Cited by 13 publications

References 62 publications

Propolis in Metabolic Syndrome and Its Associated Chronic Diseases: A Narrative Review

Propolis in Metabolic Syndrome and Its Associated Chronic Diseases: A Narrative Review

Experimental Evidence for Therapeutic Potentials of Propolis

Effect of spinach-derived glutathione against carbon tetrachloride-induced stress in rats

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