Proportion of B cell subsets and Nrf2 mediated redox regulation in systemic lupus erythematosus patients

Gautam, Preeti; Kaushal, Jyotsana; Sharma, Aman; Bhatnagar, Archana

doi:10.1016/j.imbio.2022.152180

Cited by 6 publications

(4 citation statements)

References 48 publications

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“…In the present study, Nrf2 protein levels were positively correlated with disease activity (SLEDAI scores), and previous studies have also pointed out that Nrf2 expression in B cells of patients with SLE positively correlated with disease severity (SLEDAI score) (21). We further verified the relationship between SLEDAI scores and Nrf2 protein expression by following up with similar patients with who did not have a significant decrease in eGFR.…”

Section: Discussionsupporting

confidence: 87%

“…As reported in the literature, Nrf2 protein level correlated with eGFR (17), proteinuria (18), diabetes mellitus (19), C-reactive protein (CRP) (20), and SLEDAI score (21) in renal diseases. In the present study in patients with LN, Nrf2 protein level positively correlated with eGFR and the SLEDAI score.…”

Section: Bivariate Correlation Analysis For Nrf2mentioning

confidence: 63%

“…In clinical studies, polymorphisms in the human NRF2 gene were associated with pediatric LN ( 27 ), and Nrf2 expression was upregulated in the kidneys of patients with LN ( 24 ). However, Nrf2 levels decreased in dendritic cells of patients with SLE ( 28 ), whereas Nrf2 expression increased in activated T and B cells ( 21 , 29 ). Accumulating reports support the regulatory role of Nrf2 in LN.…”

Section: Discussionmentioning

confidence: 99%

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Association of serum Nrf2 protein levels with disease activity and renal impairment in lupus nephritis

Li,

Guo,

Wei

et al. 2024

Front. Immunol.

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IntroductionWe aimed to investigate the relationship between nuclear factor erythroid 2-related factor 2 (Nrf2) protein expression levels, lupus nephritis (LN) disease activity, and the degree of renal injury (based on the estimated glomerular filtration rate [eGFR]) in patients with LN.MethodsWe selected 40 healthy control participants and 102 patients with LN who were treated in the Second Hospital of Jilin University, China, for inclusion in this study. Patients with LN were classified into LN with high-eGFR and LN with low-eGFR groups. Nrf2 protein levels were measured in the serum and renal tissues of the participants in both groups to assess the correlation between Nrf2 protein levels and different LN disease states.ResultsThere was a significantly positive correlation between serum Nrf2 protein levels, the degree of renal injury, and systemic lupus erythematosus disease activity index (SLEDAI) scores in patients with LN. Nrf2 protein levels were higher in the LN with high-eGFR group than in the healthy control and LN with low-eGFR groups. In follow-up patients in the LN high eGFR group, Nrf2 protein levels decreased significantly after remission of disease activity.ConclusionNrf2 protein expression has a dual role in patients with LN. Nrf2 protein levels not only correlate with disease activity in patients with LN, but also with the degree of kidney injury. Before implementing targeted therapy for Nrf2, evaluating both Nrf2 protein expression and the disease state in patients with LN is necessary to better identify and place each patient in an appropriate patient group.

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Section: Discussionsupporting

confidence: 87%

Section: Bivariate Correlation Analysis For Nrf2mentioning

confidence: 63%

Section: Discussionmentioning

confidence: 99%

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Association of serum Nrf2 protein levels with disease activity and renal impairment in lupus nephritis

Li,

Guo,

Wei

et al. 2024

Front. Immunol.

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“…This upregulation of ROS is important for BCR signaling and proliferation, and in determining B cell fate after activation ( 82 , 83 ). A recent study showed that in patients of systemic lupus erythematosus, B cells harbor heightened levels of cytosolic ROS and increased expression of Nrf2 ( 85 ). At the pre-B developmental stage, upon expression of pre-BCR, these cells also undergo rapid proliferation with high uptake of glucose and enhanced mitochondrial ROS generation ( 86 ).…”

Section: Introductionmentioning

confidence: 99%

Beyond Antioxidation: Keap1–Nrf2 in the Development and Effector Functions of Adaptive Immune Cells

et al. 2023

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Ubiquitously expressed in mammalian cells, the Kelch-like ECH-associated protein 1 (Keap1)–NF erythroid 2–related factor 2 (Nrf2) complex forms the evolutionarily conserved antioxidation system to tackle oxidative stress caused by reactive oxygen species. Reactive oxygen species, generated as byproducts of cellular metabolism, were identified as essential second messengers for T cell signaling, activation, and effector responses. Apart from its traditional role as an antioxidant, a growing body of evidence indicates that Nrf2, tightly regulated by Keap1, modulates immune responses and regulates cellular metabolism. Newer functions of Keap1 and Nrf2 in immune cell activation and function, as well as their role in inflammatory diseases such as sepsis, inflammatory bowel disease, and multiple sclerosis, are emerging. In this review, we highlight recent findings about the influence of Keap1 and Nrf2 in the development and effector functions of adaptive immune cells, that is, T cells and B cells, and discuss the knowledge gaps in our understanding. We also summarize the research potential and targetability of Nrf2 for treating immune pathologies.

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4-Octyl Itaconate Inhibits Proinflammatory Cytokine Production in Behcet’s Uveitis and Experimental Autoimmune Uveitis

Wang,

Ye,

Tan

et al. 2024

Inflammation

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Proportion of B cell subsets and Nrf2 mediated redox regulation in systemic lupus erythematosus patients

Cited by 6 publications

References 48 publications

Association of serum Nrf2 protein levels with disease activity and renal impairment in lupus nephritis

Association of serum Nrf2 protein levels with disease activity and renal impairment in lupus nephritis

Beyond Antioxidation: Keap1–Nrf2 in the Development and Effector Functions of Adaptive Immune Cells

4-Octyl Itaconate Inhibits Proinflammatory Cytokine Production in Behcet’s Uveitis and Experimental Autoimmune Uveitis

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