Proportion of Flat- and Depressed-Type and Laterally Spreading Tumor Among Advanced Colorectal Neoplasia

Kaku, Eisuke; Oda, Yasushi; Murakami, Yoshitaka; Goto, Hiraaki; Tanaka, Tomofumi; Hasuda, Kiwamu; Yasunaga, Makoto; Ito, Kota; Sakurai, Katsunobu; Fujimori, Takahiro; Hattori, Masahiro; Sasaki, Yutaka

doi:10.1016/j.cgh.2011.03.018

Cited by 68 publications

(58 citation statements)

References 26 publications

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“…These include lesser quality of colon cleansing in the proximal than in the distal colon, and the importance of trained and experienced endoscopists; indeed, the proximal colon may be difficult to reach and explore properly, especially in women [23]. In addition, proximal adenomas are often flat, and difficult to identify and remove [24], even by an experienced endoscopist. However, analyses stratified on year 2002, which could account for progress in endoscopic techniques, led to similar results in the two periods.…”

Section: Discussionmentioning

confidence: 93%

Colonoscopy reduced distal colorectal cancer risk and excess cancer risk associated with family history

Morois

Cottet

Racine

et al. 2014

Cancer Causes Control

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Section: Discussionmentioning

confidence: 93%

Colonoscopy reduced distal colorectal cancer risk and excess cancer risk associated with family history

Morois

Cottet

Racine

et al. 2014

Cancer Causes Control

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“…Several reports indicated that the KRAS mutation rate is lower in superficial tumors than in protruding tumors (23,24), while the granular type of laterally spreading tumor (LSTG), which is a variant type of superficial tumors, is known to have a high KRAS mutation rate (76.5 -78%) and occurs frequently in the rightsided colon (25,26). LSTG has recently been receiving much attention as an important precursor of colorectal cancer (25,26), and the higher KRAS mutation rate in right-sided colon cancer may be due to more colon cancer originating from LSTG in the right-sided colon (27).…”

Section: Kras Mutational Status In Japanese Patientsmentioning

confidence: 99%

KRAS Mutational Status in Japanese Patients with Colorectal Cancer: Results from a Nationwide, Multicenter, Cross-sectional Study

Watanabe

Yoshino

Uetake

et al. 2013

Japanese Journal of Clinical Oncology

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Objective: KRAS gene mutations are a useful predictive factor for the efficacy of anti-epidermal growth factor receptor therapeutics. Since there were no large-scale studies among Asian populations, we designed an observational nationwide study in Japan. Methods: Formalin-fixed paraffin-embedded tissue blocks or sections from primary or metastatic lesions were obtained from patients registered between 2009 and 2010 for genomic DNA extraction. KRAS gene was analyzed by direct sequencing or Luminex assay. The primary endpoint was the frequency of KRAS gene mutations and the secondary endpoints were differences in KRAS mutation rates by various stratification factors. Univariate and multivariate analyses were performed to investigate relationships between KRAS mutation rates and patient background factors. Results: We analyzed 5790 eligible samples out of 5887 registered. The overall KRAS mutation rate was 37.6%, with 29.9% in codon 12 and 7.7% in codon 13, and wild type was 62.4%. A significant relationship with the KRAS mutation rate was found for gender, age, the year that the sample was prepared and the site of the primary lesion. Conclusion: The KRAS mutation rate of Japanese colorectal cancer patients was 37.6%. Gender, age, the site of the primary lesion and the year that the sample was prepared were independent risk factors for KRAS mutations.

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“…In the last decade, flat and depressed lesions, including the ‘laterally spreading tumours', have raised growing attention [8,9], in particular as some studies indicated a higher risk of malignancy for these subtypes compared to protruding adenomas [10,11,12,13]. However, data obtained from a large asymptomatic adult screening population (n = 52,521) showed that polyp size (p < 0.0001) but not polyp shape (p = 0.438) is an independent predictor of high-grade dysplasia, i.e.…”

Section: Conventional Adenomasmentioning

confidence: 99%

Serrated and Non-Serrated Precursor Lesions of Colorectal Cancer

Langner¹

2014

Dig Dis

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Although often viewed as a single disease, colorectal cancer more accurately represents a family of diseases with different precursor lesions. Conventional (tubular, tubulovillous and villous) adenomas are the most common neoplastic lesions occurring in the large intestine. They have adenomatous polyposis coli (APC) mutations and arise from dysplastic aberrant crypt foci, initially as polyclonal lesions. In sporadic tumours, neoplastic progression follows the traditional pathway (chromosomal instability pathway), resulting in CpG island methylator phenotype (CIMP)-negative, microsatellite-stable (MSS), BRAF and KRAS wild-type cancers. Germline mutations in the APC gene lead to familial adenomatous polyposis. Conventional adenomas are also the precursors of Lynch syndrome-associated microsatellite-instable (MSI-high) cancers. Sessile serrated adenoma/polyp (SSA/P) is the principal precursor lesion of the serrated pathway, in which BRAF mutation can lead to colorectal cancer with MSI-high CIMP-high or MSS CIMP-high phenotype. SSA/Ps have been associated with synchronous and metachronous invasive adenocarcinomas as well as so-called interval carcinomas. Serrated polyposis is rare but most likely underdiagnosed. Affected individuals bear an increased but unspecified risk for the development of colorectal cancer; close endoscopic surveillance is warranted. Traditional serrated adenomas (TSAs) are much less common than the other serrated lesions. Cancers originating from TSAs may show KRAS mutation with a CIMP-high MSS phenotype.

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Proportion of Flat- and Depressed-Type and Laterally Spreading Tumor Among Advanced Colorectal Neoplasia

Cited by 68 publications

References 26 publications

Colonoscopy reduced distal colorectal cancer risk and excess cancer risk associated with family history

Colonoscopy reduced distal colorectal cancer risk and excess cancer risk associated with family history

KRAS Mutational Status in Japanese Patients with Colorectal Cancer: Results from a Nationwide, Multicenter, Cross-sectional Study

Serrated and Non-Serrated Precursor Lesions of Colorectal Cancer

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