2020
DOI: 10.1186/s12876-020-1165-z
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Proportion of NAFLD patients with normal ALT value in overall NAFLD patients: a systematic review and meta-analysis

Abstract: Background: ALT value is often used to reflect the hepatic inflammation and injury in NAFLD patients, but many studies proved that ALT values were normal in many NAFLD patients. The aim of this study was to identify the summarized proportion of NAFLD patients with normal ALT value in the overall NAFLD patients. Methods: Electronic databases PubMed, EMBASE, Ovid, and the Cochrane Library were searched for potential studies published from . Studies that have reported the number of NAFLD or NASH patients with nor… Show more

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Cited by 118 publications
(73 citation statements)
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“…On the other hand, 60% of the patients with NAFLD had normal ALT. These figures are in line with data from the general population and suggest the development of NAFLD may be occult[ 58 , 59 ]. This finding emphasizes the need for sensitive diagnostic tools in this at-risk population.…”
Section: Discussionsupporting
confidence: 87%
“…On the other hand, 60% of the patients with NAFLD had normal ALT. These figures are in line with data from the general population and suggest the development of NAFLD may be occult[ 58 , 59 ]. This finding emphasizes the need for sensitive diagnostic tools in this at-risk population.…”
Section: Discussionsupporting
confidence: 87%
“… 20 , 21 This method is controversial because some studies illustrated that there is no significant difference in ALT and AST levels between patients with NAFL and NASH. 22 We found elevated ALT and AST levels in NAFL mice, but we could not use these two markers to distinguish NAFL and NASH. This preclinical evidence supports the idea that NAFL cannot be distinguished from NASH using ALT and AST alone.…”
Section: Discussionmentioning
confidence: 68%
“…First, calculation of FIB-4 index requires only four parameters, age, AST, ALT, and platelet count, while calculating the formula of NFS is slightly more complex [ 26 ] ( Table 1 ). Second, FIB-4 index is available even in MAFLD patients with normal ALT levels [ 42 , 43 , 44 ]. A meta-analysis proved that 25% MAFLD patients and 19% NASH patients possess the normal ALT value [ 43 ].…”
Section: The Usefulness Of Fib-4 Index To Evaluating Severe Fibrosmentioning
confidence: 99%