Proposal for prevention and control of the 2019 novel coronavirus disease in newborn infants

Li, Fang; Feng, Zhi Chun; Shi, Yuan

doi:10.1136/archdischild-2020-318996

Cited by 41 publications

(52 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…16 Chinese neonatologists and obstetricians have recently proposed how to prevent and control COVID-19 infections in newborn infants. 22,38,60 Until now, there have been no reports of COVID-19 transmission within neonatal intensive care units, but although children seem to have less symptoms than adult patients also newborn infants can suffer from respiratory distress and are likely to transmit the disease if sick. 8 The main strength of this study was that it used well-established databases and wide-ranging search terms to pick up as many studies as possible up to March 18, 2020.…”

Section: Novel Coronavirus Pneumonia Emergency Response Epidemiologymentioning

confidence: 99%

Systematic review of COVID‐19 in children shows milder cases and a better prognosis than adults

2020

View full text Add to dashboard Cite

Aim:The coronavirus disease 2019 pandemic has affected hundreds of thousands of people. Data on symptoms and prognosis in children are rare. Methods:A systematic literature review was carried out to identify papers on COVID-19, which is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), using the MEDLINE and Embase databases between January 1 and March 18, 2020. Results:The search identified 45 relevant scientific papers and letters. The review showed that children have so far accounted for 1%-5% of diagnosed COVID-19 cases, they often have milder disease than adults and deaths have been extremely rare.Diagnostic findings have been similar to adults, with fever and respiratory symptoms being prevalent, but fewer children seem to have developed severe pneumonia.Elevated inflammatory markers were less common in children, and lymphocytopenia seemed rare. Newborn infants have developed symptomatic COVID-19, but evidence of vertical intrauterine transmission was scarce. Suggested treatment included providing oxygen, inhalations, nutritional support and maintaining fluids and electrolyte balances. Conclusions:The coronavirus disease 2019 has occurred in children, but they seemed to have a milder disease course and better prognosis than adults. Deaths were extremely rare.

show abstract

Section: Novel Coronavirus Pneumonia Emergency Response Epidemiologymentioning

confidence: 99%

Systematic review of COVID‐19 in children shows milder cases and a better prognosis than adults

2020

View full text Add to dashboard Cite

show abstract

“…Clinical features of infected newborns, especially preterm infants, might be non-specific and include acute respiratory distress syndrome, temperature instability, gastrointestinal and cardiovascular dysfunction. All infants with suspected COVID-19 should be isolated and monitored, whether symptomatic or not [41]. In the cohort described by Zhu et al [35], nine of ten neonates born to mothers with confirmed COVID-19 presented with shortness of breath (n = 6), cyanosis (n = 3), vomiting and feeding intolerance (n = 2), fever (n = 2), increased heart rate (n = 1), moaning and rashes (n = 3).…”

Section: Clinical Features In Newborns and Infantsmentioning

confidence: 99%

“…A SARS-CoV-2 test should be performed after birth: all probable or laboratory-confirmed newborns with SARS-CoV-2 should be isolated or cohorted in a single room (if possible) for at least 14 days. The quarantine room should be equipped with an isolated air cycle system and, given SARS-CoV-2 high infectivity, negative pressure isolation rooms are recommended, albeit rarely available [41]. Standard and additional infection control measures should be implemented immediately [47], such as visitor restriction policies and protected pathways.…”

Section: Infection Control and Treatmentmentioning

confidence: 99%

Novel Coronavirus disease (COVID-19) in newborns and infants: what we know so far

et al. 2020

View full text Add to dashboard Cite

Recently, an outbreak of viral pneumonitis in Wuhan, Hubei, China successively spread as a global pandemia, led to the identification of a novel betacoronavirus species, the 2019 novel coronavirus, successively designated 2019-nCoV then SARS-CoV-2). The SARS-CoV-2 causes a clinical syndrome designated coronavirus disease 2019 (COVID19) with a spectrum of manifestations ranging from mild upper respiratory tract infection to severe pneumonitis, acute respiratory distress syndrome (ARDS) and death. Few cases have been observed in children and adolescents who seem to have a more favorable clinical course than other age groups, and even fewer in newborn babies. This review provides an overview of the knowledge on SARS-CoV-2 epidemiology, transmission, the associated clinical presentation and outcomes in newborns and infants up to 6 months of life.

show abstract

“…Möglicherweise liegt das Hauptrisiko eher in der Tröpfcheninfektion aus den mütterlichen Atemwegen während des Stillens (horizontale Transmission) 29 . Obwohl das Stillen für das Neugeborene und für die Bindung zwischen Mutter und Kind wichtig ist, vermieden Kollegen in China noch im Februar 2020 eine klare Positionierung für oder gegen das Stillen bei isolierten Neugeborenen 41 . Anzunehmen ist aber auch die Weitergabe von SARS-CoV-2-Antikörpern über die Muttermilch an das Kind, was den klinischen Verlauf einer kindlichen Infektion positiv beeinflussen könnte, ähnlich wie es bei der SARS-Epidemie 2002/2003 berichtet wurde 42 .…”

Section: Haupttextunclassified

Perinatale Aspekte der SARS-CoV-2 Infektion

Longardt

Winkler

Pecks

2020

Z Geburtshilfe Neonatol

View full text Add to dashboard Cite

ZusammenfassungDas neuartige Coronavirus SARS-CoV-2 hat sich zu einer Pandemie entwickelt, in der es noch viele Unbekannte gibt. Die Modalitäten der Übertragung, unterschiedlichen Symptome und Ausprägungen sowie Begleiterscheinung der Erkrankung sind unzureichend charakterisiert. Gerade Patientengruppen in besonderen Situationen wie Schwangere und Neugeborene müssen dabei separat betrachtet werden. Das bisherige Wissen zu Schwangerschaft, Geburt und den ersten Lebenstagen ist aufgrund der spärlichen Datenlage von besonderer Unsicherheit geprägt. Es bestehen aber derzeit keine Hinweise für eine signifikante Verschlechterung im maternalen und perinatalen Outcome. Viele Schwangere mit SARS-CoV-2-Infektion bleiben asymptomatisch. Die Möglichkeit einer vertikalen Transmission auf das Kind kann nicht sicher ausgeschlossen werden. Hinweise hierauf ergaben sich jedoch bislang nur aus Einzelfällen. Auch Neugeboreneninfektionen sind eher selten, unspezifisch und verlaufen meist mild, wobei respiratorische Symptome dominieren. In diesem Artikel wird die bisherige Datenlage beleuchtet, um eine bessere Aufklärung, Beratung und Behandlung der Schwangeren und Neugeborenen mit SARS-CoV-2 zu ermöglichen und um Anregungen für die zukünftige Forschung zu geben.

show abstract

Proposal for prevention and control of the 2019 novel coronavirus disease in newborn infants

Cited by 41 publications

References 2 publications

Systematic review of COVID‐19 in children shows milder cases and a better prognosis than adults

Systematic review of COVID‐19 in children shows milder cases and a better prognosis than adults

Novel Coronavirus disease (COVID-19) in newborns and infants: what we know so far

Perinatale Aspekte der SARS-CoV-2 Infektion

Contact Info

Product

Resources

About