Proposed model for growth preference of plate-like nanohydroxyapatite crystals on superhydrophilic vertically aligned carbon nanotubes by electrodeposition

Lobo, Anderson Oliveira; Marciano, Fernanda Roberta; Regiani, Inacio; Ramos, Susana; Matsushima, Jorge Tadao; Corat, Evaldo José

doi:10.1007/s00214-011-0993-x

Cited by 15 publications

(28 citation statements)

References 61 publications

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“…The rod-like shape and nanoscale of CNTs make it possible to use them as reinforcement materials to simulate collagen fibers in the ECM [52,53,54,55]. Currently, existing nanometer synthesis methods can prepare parallel or randomly orientated CNTs with a similar fibrillar hierarchy structure to ECM, and MWCNTs have been proven to reflect the band/gap structure of collagen as bone-like HA [56,57]. Furthermore, these tubular CNTs have an extremely large surface-area-to-volume ratio, making them suitable for supplying more sites for efficient adhesion of proteins, as well as providing higher drug loading capacity [58].…”

Section: Advantages For Using Cnt Composite Materials For Bone Tismentioning

confidence: 99%

Applications of Carbon Nanotubes in Bone Tissue Regeneration and Engineering: Superiority, Concerns, Current Advancements, and Prospects

et al. 2019

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With advances in bone tissue regeneration and engineering technology, various biomaterials as artificial bone substitutes have been widely developed and innovated for the treatment of bone defects or diseases. However, there are no available natural and synthetic biomaterials replicating the natural bone structure and properties under physiological conditions. The characteristic properties of carbon nanotubes (CNTs) make them an ideal candidate for developing innovative biomimetic materials in the bone biomedical field. Indeed, CNT-based materials and their composites possess the promising potential to revolutionize the design and integration of bone scaffolds or implants, as well as drug therapeutic systems. This review summarizes the unique physicochemical and biomedical properties of CNTs as structural biomaterials and reinforcing agents for bone repair as well as provides coverage of recent concerns and advancements in CNT-based materials and composites for bone tissue regeneration and engineering. Moreover, this review discusses the research progress in the design and development of novel CNT-based delivery systems in the field of bone tissue engineering.

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Section: Advantages For Using Cnt Composite Materials For Bone Tismentioning

confidence: 99%

Applications of Carbon Nanotubes in Bone Tissue Regeneration and Engineering: Superiority, Concerns, Current Advancements, and Prospects

et al. 2019

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“…The wettability in polar liquids, such as water, improved significantly in this way, leading to more reactive VAMWCNT surfaces 17 . The oxygen plasma etching is the most efficient way to introduce polar groups (COH, OH, C=O, COOH) and roughness to VAMWCNT in order to obtain superhydrophilic behavior 18 . Figures 1c and 1d show the efficiency of the oxygen plasma treatment on converting VAMWCNT surfaces from superhydrophobic to superhydrophilic behavior, comparing contact angle between deionized water on VAMWCNT before (1c) and after (1d) the oxygen plasma treatment.…”

Section: Characterization Of Nhap/vamwcnt-o 2 Nanocompositesmentioning

confidence: 99%

“…This top surface is heavily attacked by oxygen plasma, which is responsible for the grafting of the oxygen groups onto VAMWCNT-O 2 and a further roughening of the VAMWCNT-O 2 surfaces. Clearly, the rapid and direct electrodeposition of plate-like nHAp crystals on VAMWCNT-O 2 films is highly influenced by the COOH groups and VAMWCNT-O 2 rough nanotopology surface 18 . The mechanism for nHAp crystal formation on VAMWCNT-O 2 films was already proposed and discussed in literature 18 .…”

Section: Sem (mentioning

confidence: 99%

“…Clearly, the rapid and direct electrodeposition of plate-like nHAp crystals on VAMWCNT-O 2 films is highly influenced by the COOH groups and VAMWCNT-O 2 rough nanotopology surface 18 . The mechanism for nHAp crystal formation on VAMWCNT-O 2 films was already proposed and discussed in literature 18 . The schematic reaction ilustration of plate-like nHAp crystals formation and dissolution during direct electrodeposition on VAMWCNT-O 2, to form nHAp/ VAMWCNT-O 2 composite is shown in Figure 2 18 .…”

Section: Sem (mentioning

confidence: 99%

“…Figure 2. Schematic illustration of plate-like nHAp crystals formation and dissolution during direct electrodeposition on VAMWCNT-O 2 s surfaces based on Lobo et al model 18 . Figure 3 shows SEM micrography of nHAp/ VAMWCNT-O 2 surfaces before (Figure 3a) and after biomineralization process (Figure 3b-d).…”

Section: Sem (mentioning

confidence: 99%

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Proposed model for biomineralization of novel nanohydroxyapatite/vertically aligned multiwalled carbon nanotube scaffolds

et al. 2013

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For the first time, the growth mechanism of biominerals formed on plate-like nanohydroxyapatite (nHAp) electrodeposited on superhydrophilic vertically aligned multi-walled carbon nanotubes (VAMWCNT-O 2 ) is presented and a model for the specific growth preference is discussed. VAMWCNT-O 2 films were obtained by microwave-assisted chemical vapor deposition method and funcionalized by oxygen plasma. nHAp/VAMWCNT-O 2 nanocomposites were fabricated with a direct electrodeposition of the thin nHAp films onto the VAMWCNT-O 2 films. The biomineralized "scaffolds" were obtained by soaking nHAp/VAMWCNT-O 2 in simulated body fluid for 7, 14 and 21 days. Results show that the carboxyl functional groups directly attached onto VAMWCNT tips after oxygen plasma treatment were essential for the acceleration of the OH-formation and the deposition of plate-like nHAp crystals.

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In vitro and in vivo studies of a novel nanohydroxyapatite/superhydrophilic vertically aligned carbon nanotube nanocomposites

Lobo

Siqueira

Neves

et al. 2013

J Mater Sci: Mater Med

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An association between in vitro and in vivo studies has been demonstrated for the first time, using a novel nanohydroxyapatite/superhydrophilic vertically aligned multiwalled carbon nanotube (nHAp/VAMWCNT-O2) nanocomposites. Human osteoblast cell culture and bone defects were used to evaluate the in vitro extracellular matrix (ECM) calcification process and bone regeneration, respectively. The in vitro ECM calcification process of nHAp/VAMWCNT-O2 nanocomposites were investigated using alkaline phosphatase assay. The in vivo biomineralization studies were carried out on bone defects of C57BL/6/JUnib mice. Scanning electron microscopy, micro-energy dispersive spectroscopy, X-ray photoelectron spectroscopy, and X-ray difractometry analyses confirmed the presence of the nHAp crystals. nHAp/VAMWCNT-O2 nanocomposites induced in vitro calcification of the ECM of human osteoblast cells in culture after only 24 h. Bone regeneration with lamellar bone formation after 9 weeks was found in the in vivo studies. Our findings make these new nanocomposites very attractive for application in bone tissue regeneration.

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Proposed model for growth preference of plate-like nanohydroxyapatite crystals on superhydrophilic vertically aligned carbon nanotubes by electrodeposition

Cited by 15 publications

References 61 publications

Applications of Carbon Nanotubes in Bone Tissue Regeneration and Engineering: Superiority, Concerns, Current Advancements, and Prospects

Applications of Carbon Nanotubes in Bone Tissue Regeneration and Engineering: Superiority, Concerns, Current Advancements, and Prospects

Proposed model for biomineralization of novel nanohydroxyapatite/vertically aligned multiwalled carbon nanotube scaffolds

In vitro and in vivo studies of a novel nanohydroxyapatite/superhydrophilic vertically aligned carbon nanotube nanocomposites

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