Proposed Rectal Dose Constraints for Patients Undergoing Definitive Whole Pelvic Radiotherapy for Clinically Localized Prostate Cancer

Does Image-Guided Radiotherapy (IG-IMRT) Improve Toxicity Profile in Whole Pelvic–Treated High-Risk Prostate Cancer? Comparison Between IG-IMRT and IMRT: In regard to Chung et al. (Int J Radiat Oncol Biol Phys 2008. In press)

“…Because each group of patients is treated wan a different center, the photon beam energy may be different if the machines did not have the same energy. Although photon energy does not have a significant role in inverse planning techniques (2), studies have shown that it could increase the dose to regions distant from the target when 6-MV photons are used with less than nine fields (seven fields were used in the present study) (3). There is a lack of clinical studies about this increased dose distant from the target in terms of complications.…”

“…TRA-8 is a monoclonal antibody (mAb) that binds to DR5 and activates the extrinsic apoptosis pathway. The study by Fiveash et al (3) reveals that TRA-8, in combination with temozolomide and radiotherapy, augments cytotoxicity of glioblastoma cell lines. However, the results of the in vivo portion of the experiment (subcutaneous and intracranial), in which TRA-8 was delivered intraperitoneally, were less striking.…”

Intensity-modulated Radiotherapy Combined with Endocrine Therapy for Intermediate and Advanced Prostate Cancer: Long-term Outcome of Chinese Patients

“…With the increase in the dose of external radiation, an improved local control rate and long-term survival can be achieved in patients with prostate cancer (Chan et al, 2008;Zelefsky et al, 2008). However, conventional radiotherapy with a dose > 70 Gy has been demonstrated to cause more severe rectal and bladder toxicity (Hanks et al, 1997).…”

Pelvic Nodal Radiotherapy in Patients With Unfavorable Intermediate and High-Risk Prostate Cancer: Evidence, Rationale, and Future Directions

“…Intensity modulated radiation therapy (IMRT) and image-guided radiotherapy techniques allow more comprehensive coverage of targets while reducing the dose to surrounding normal structures (80)(81)(82). RTOG 9413 suggest that at a minimum with WPRT the superior border of the field should be placed at least at the level of L5-S1 (Fig.…”