2023
DOI: 10.48208/headachemed.2023.2
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Propranolol: A migraine prophylactic since the 1960s

Abstract: IntroductionPropranolol was the first non-selective beta-adrenergic blocker to be developed. Initially it was used in the treatment of cardiovascular diseases, but since the 60's it has been used in the prevention of migraine.ObjectiveThe objective of this study was to know the history of propranolol and its use as a migraine prophylactic.MethodsThis study was an integrative literature review using articles with historical data on propranolol, from its origin in cardiology to its indication in the preventive t… Show more

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Cited by 2 publications
(3 citation statements)
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“…With the discovery of the mechanism of migraine over time, drugs that can be used in its treatment have been approved by the FDA. Ergot alkaloids, 72 valproate, topiramate, 73 β-blockers, 74 calcium channel blockers, 75 and amitriptyline 76 are the most commonly used drugs in migraine treatment. 6.1.…”
Section: Migraine Drugs and Their Synthesismentioning
confidence: 99%
“…With the discovery of the mechanism of migraine over time, drugs that can be used in its treatment have been approved by the FDA. Ergot alkaloids, 72 valproate, topiramate, 73 β-blockers, 74 calcium channel blockers, 75 and amitriptyline 76 are the most commonly used drugs in migraine treatment. 6.1.…”
Section: Migraine Drugs and Their Synthesismentioning
confidence: 99%
“…21 The first beta-blocker to be used clinically was propranolol in 1964. 22 The mechanisms of action are related to its ability to act centrally on the serotonergic and noradrenergic neurotransmitter systems. The various beta-blockers differ in terms of selectivity for β1 and β2 receptors, their lipophilic capacity and blood-brain penetration.…”
Section: Beta-adrenergic Blockersmentioning
confidence: 99%
“…In addition, they interact with serotonergic 5-HT 2B and 5-HT 2C receptors, promoting their down regulation. 18,20,23 The most used beta-blockers with proven efficacy are propranolol (the oldest), 22 at doses from 30 to 180 mg/ day; metoprolol, at doses of 50 to 200 mg/day; atenolol, at doses of 50 to 120 mg/day; and nadolol, at doses from 80 to 240 mg/day (Table 2). Nadolol is the only one with predominantly renal excretion, without hepatic metabolism and more present in breast milk.…”
Section: Beta-adrenergic Blockersmentioning
confidence: 99%