Propranolol and beta‐adrenergic receptor blocking drugs in the treatment of hypertension.

Prichard, B. N. C.

doi:10.1111/j.1365-2125.1982.tb01336.x

Cited by 24 publications

(7 citation statements)

References 71 publications

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“…This result suggests that 320 mg inhibited 3-adrenoceptor mediated tachycardia over 24 h. The lack of effect of LA propranolol 160 mg shows the insensitivity of these variables as indices of 0-adrenoceptor blockade in PHT, and stresses the importance of measuring exercise rather than resting HR in assessing the efficacy of ,3-adrenoceptor antagonists (Prichard, 1982;Oh, 1979).…”

Section: Discussionmentioning

confidence: 95%

“…Whereas the action of ordinary propranolol in systemic hypertension is well known (Prichard, 1982), that of long-acting (LA) preparations of 1-adrenoceptor antagonists is not well shown in controlled, double-blind studies (Watson et al, 1981). A long-acting drug formulation should lower BP continually at rest and during exercise without important unwanted effects.…”

Section: Introduction Methodsmentioning

confidence: 99%

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Effects of long‐acting propranolol on blood pressure and heart rate in hypertensive Chinese.

Oh¹,

Chia²,

Taylor³

1985

Brit J Clinical Pharma

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In a double-blind, balanced and randomised study we used treadmill exercise to assess the effects of long-acting propranolol (LA propranolol) 160 or 320 mg or placebo, given once daily for 4 weeks, on heart rate (HR) and blood pressure (BP) in 15 Chinese subjects with mild primary hypertension (PHT). We used 24 h ECG monitoring to assess drug effects on HR. Another 18 patients were similarly assessed without exercise. Steady-state plasma propranolol concentrations after LA propranolol 160 and 320 mg were comparable to those after ordinary propranolol 80 and 160 mg daily measured in 11 and 12 separate patients. LA propranolol 160 and 320 mg reduced HR and BP before and during vigorous exercise. LA propranolol 160 and 320 mg reduced HR for 17.6 and 21.4 h of the day, and 320 mg significantly reduced the mean 24 h HR, and the mean maximum HR. The drug effects on BP and HR, and the average plasma propranolol levels after LA propranolol were similar to those reported in European subjects.

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Section: Discussionmentioning

confidence: 95%

Section: Introduction Methodsmentioning

confidence: 99%

Effects of long‐acting propranolol on blood pressure and heart rate in hypertensive Chinese.

Oh¹,

Chia²,

Taylor³

1985

Brit J Clinical Pharma

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“…~-Adrenoceptor blockers are used extensively to treat angina (Chamberlain 1987;Thadani & Parker 1979), to control hypertension (Prichard 1964(Prichard , 1982 and to improve the prognosis of patients who survive a myocardial infarction (Beta Blocker Heart Attack Research Trial Group 1982;Norwegian Study Group 1981). In each clinical situation the prescribing doctor has a number of alternative drug treatments to offer the patient (table I).…”

Section: Discussionmentioning

confidence: 99%

A Risk-Benefit Assessment of Celiprolol in the Treatment of Cardiovascular Disease

Kendall

Rajman

1994

Drug Safety

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Celiprolol is a third-generation beta-adrenoceptor blocker with selective beta 1-antagonist, partial beta 2-agonist and mild alpha 2-antagonist actions. It seems to be as effective as other beta-blockers in the treatment of hypertension and angina pectoris. beta-Blockers have many cardioprotective effects and have been shown to reduce the morbidity and mortality from coronary artery disease in a number of trials. However, there is no good clinical evidence that celiprolol itself has specific cardioprotective properties other than those attributable to this class of drugs. Because of its pharmacological profile, celiprolol is less likely to cause bradycardia, deterioration in cardiac function and other adverse effects mainly caused by beta 2-blockade. Unlike most other beta-blockers, celiprolol has no adverse effects on plasma lipids. It seems to be well tolerated in diabetic patients and patients with renal dysfunction.

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“…31 Garlic homogenate with propranolol cause increase in the bioavailability and halflife along with decrease clearance and elimination rate constant of propranolol it is found to be most effective in reducing systolic blood pressure 32 …”

Section: Antihypertensivementioning

confidence: 99%

Possible interactions between garlic and conventional drugs: a review

Kansara

Jani

2017

PBE

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Herbs can affect body function; therefore, when herbs are taken concurrently with drugs, interactions are possible. The interaction between drugs and herbal medicines is a safe concern and these interactions are especially important for drugs with narrow therapeutics index. The probability of herb-drug interaction can be higher than drug interaction, if conventional drug having single chemical entities, whereas most of the herbal medicinal product contain a mixture of pharmacologically active constituents. The herb-drug interaction may involve either an increase or decrease in the amount of drug in blood, either by altering the absorption, distribution, metabolism, and elimination (ADME) of drug and by antagonizing or synergism of the effect of drug or pharmacodynamics interaction may arise. This article we focus on how garlic interacts with conventional drug or it is favourable or not.

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Propranolol and beta‐adrenergic receptor blocking drugs in the treatment of hypertension.

Cited by 24 publications

References 71 publications

Effects of long‐acting propranolol on blood pressure and heart rate in hypertensive Chinese.

Effects of long‐acting propranolol on blood pressure and heart rate in hypertensive Chinese.

A Risk-Benefit Assessment of Celiprolol in the Treatment of Cardiovascular Disease

Possible interactions between garlic and conventional drugs: a review

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