Propranolol overdose — a dramatic response to calcium chloride

Brimacombe, J.; Scully, M.; Swainston, Robin

doi:10.5694/j.1326-5377.1991.tb142238.x

Cited by 34 publications

(9 citation statements)

References 19 publications

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“…These mechanisms with the involvement of calcium and sodium channels could explain the effects of calcium‐chloride or sodium bicarbonate that have been reported to dramatically improve patients with a beta‐blocker overdose 19,20 …”

Section: Discussionmentioning

confidence: 99%

Propranolol Intoxication Revealing a Brugada Syndrome

Aouate

Clerc

Viard

et al. 2005

Cardiovasc electrophysiol

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This is the first report of Brugada syndrome revealed by beta-blocker intoxication. A 24-year-old healthy man ingested propranolol (2.28 g) to commit suicide. After early gastric lavage, electrolytes, cardiac enzymes, chest X-ray, and echocardiography were normal. Dosages of psychotropic drugs were negative. ECG showed a typical coved-type pattern of Brugada syndrome. Follow-up showed partial ECG normalization of the discrete saddleback-type pattern. The ajmaline- test confirmed Brugada syndrome. These ECG modifications may be explained by the stabilizing membrane effect of high concentration of propranolol and/or inhibition of ICaL. This case illustrates the possible deleterious effects of beta-blockers in patients with Brugada syndrome.

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Section: Discussionmentioning

confidence: 99%

Propranolol Intoxication Revealing a Brugada Syndrome

Aouate

Clerc

Viard

et al. 2005

Cardiovasc electrophysiol

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“…Multiple case reports have shown a positive clinical response to glucagon therapy in beta-blocker toxicity in conjunction with other treatments, but fewer have demonstrated the efficacy of glucagon as the sole agent. 82 Overall, clinical experience with calcium use in beta-blocker overdose is mixed. 80 In nonpoisoned individuals, onset of action of glucagon occurs at 1 to 3 min, peaks at 5 to 7 min, and effects persist for only 10 to 15 min.…”

Section: Management Of Beta-blocker Overdosementioning

confidence: 99%

Cardiovascular Toxicity of Cardiovascular Drugs

et al. 2015

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“…The quinidine‐like effect of blockade of the fast sodium channel adds to the toxicity of propranolol by potentiating the hypotensive and arrhythmogenic effects. Glucagon appears less effective in propranolol overdose than in overdose of agents without membrane stabilising activity 31 .…”

Section: Specific Treatmentmentioning

confidence: 99%

“…Must successful case reports have not used inotropes alone but in conjunction with glucagon and in some cases calcium 7,27,28 . They are beneficial in minor overdoses, but in moderate to severe toxicity, they are best considered as adjunctive therapy 7,27–31 .…”

Section: Specific Treatmentmentioning

confidence: 99%