Propyithiouracil-induced Lupus-like Syndrome Developing in a Graves' Patient with a Sibling with Systemic Lupus Erythematosus.

Yamada, Akiteru; Sato, Kanji; Hara, Mitsuhiko; Tochimoto, Akiko; Takagi, Shun; Hizuka, Naomi; Takano, Kazue

doi:10.2169/internalmedicine.41.1204

Cited by 19 publications

(7 citation statements)

References 25 publications

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“…Drug-induced lupus can also manifest as arthritis, and clinical and serological results that are consistent with lupus erythematosus have been observed in some patients who were treated using antithyroid agents ( 17 ). Interestingly, many researchers insist that it is irrelevant to distinguish between antithyroid agent-induced lupus-like syndrome and AAV ( 11 ), although other researchers make a clear distinction between these conditions ( 18 ).…”

Section: Discussionmentioning

confidence: 96%

Antithyroid Arthritis Syndrome: A Case Report and Review of the Literature

2016

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We herein report the case of a 38-year-old Japanese woman with antithyroid arthritis syndrome who experienced severe migratory polyarthritis after the initiation of thiamazole therapy. The patient's symptoms promptly disappeared without any sequelae after the withdrawal of the drug. Antithyroid arthritis syndrome is poorly characterized, and the findings from our literature review indicate that this syndrome exhibits serological features that are distinct from those of antithyroid agent-induced vasculitis syndrome. The absence of autoantibodies, especially anti-neutrophil cytoplasmic antibodies, may help characterize and diagnose antithyroid arthritis syndrome. Furthermore, physicians' awareness of this syndrome is essential for its diagnosis in clinical practice.

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Section: Discussionmentioning

confidence: 96%

Antithyroid Arthritis Syndrome: A Case Report and Review of the Literature

2016

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“…The mechanism by which anti-thyroid drugs trigger DIL could be associated with drug-mediated changes to the structure of the DNA-histone complex. The changes lead to the histone not being readily hydrolyzed, causing it to retain immunogenicity or expose new epitopes (14,15). Many drugs are metabolized into cytotoxic metabolites that lead to cell death and abnormal chromatin degradation.…”

Section: Discussionmentioning

confidence: 99%

Anti-thyroid drug-induced lupus: a case report and review of the literature

Qiu

et al. 2016

Arch. Endocrinol. Metab.

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“…We speculate that different clearance of apoptotic materials by macrophages might determine type of autoimmune response [37]. PTU-induced LLD was described in a patient with HLA DR9 haplotype whose twin sister had SLE [38]. …”

Section: Discussionmentioning

confidence: 99%