2024
DOI: 10.1002/jpen.2681
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Propyl acetate protects intestinal barrier during parenteral nutrition in mice and Caco‐2 cells

Jiwei Wang,
Jing Du,
Xiaomei Gou
et al.

Abstract: BackgroundGut microbiota dysbiosis induces intestinal barrier damage during parenteral nutrition (PN). However, the underlying mechanisms remain unclear. This study aimed to investigate gut microbiota dysbiosis, luminal short‐chain fatty acids, and autophagy in a mouse model and how these short‐chain fatty acids regulate autophagy.MethodsEight‐week‐old male specific‐pathogen–free mice were randomly divided into a Chow group (standard diet and intravenous normal saline infusion) and a PN group (continuous infus… Show more

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