Prospective cardiac motion self-gating

Han, Fei; Rapacchi, Stanislas; Hu, Peng

doi:10.21037/qims.2017.03.02

Cited by 16 publications

(15 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…54 Other approaches will be to denoise as well as design better segmentation to statistically remove ill-fitted pixels in the ROI, and employ better-fitting strategies and motion correction. 55–59 Actually, our preliminary analysis demonstrated that IVIM parameters’ scan–rescan reproducibly can be satisfactory if motion-contaminated data are carefully removed during analysis. Another limitation of our study is all our patients had liver fibrosis due to viral hepatitis-b.…”

Section: Discussionmentioning

confidence: 83%

A Combined Use of Intravoxel Incoherent Motion MRI Parameters Can Differentiate Early-Stage Hepatitis-b Fibrotic Livers from Healthy Livers

et al. 2018

View full text Add to dashboard Cite

This study investigated a combined use of intravoxel incoherent motion (IVIM) parameters, Dslow ( D), PF ( f), and Dfast ( D*), for liver fibrosis evaluation. Sixteen healthy volunteers (F0) and 33 hepatitis-b patients (stage F1 = 15, stage F2-4 = 18) were included. With a 1.5 T MR scanner and respiration gating, IVIM diffusion-weighted imaging was acquired using a single-shot echo-planar imaging sequence with 10 b values of 10, 20, 40, 60, 80, 100, 150, 200, 400, and 800 s/mm. Signal measurement was performed on right liver parenchyma. With a three-dimensional tool, Dslow, PF, and Dfast values were placed along the x axis, y axis, and z axis, and a plane was defined to separate healthy volunteers from patients. The three-dimensional tool demonstrated that healthy volunteers and all patients with liver fibrosis could be separated. Classification and regression tree showed that a combination of PF (PF < 12.55%), Dslow (Dslow < 1.152 × 10 mm/s), and Dfast (Dfast < 13.36 × 10 mm/s) could differentiate healthy subjects and all fibrotic livers (F1-4) with an area under the curve of logistic regression (AUC) of 0.986. The AUC for differentiation of healthy livers versus F2-4 livers was 1. PF offered the best diagnostic value, followed by Dslow; however, all three parameters of PF, Dslow, and Dfast contributed to liver fibrosis detection.

show abstract

Section: Discussionmentioning

confidence: 83%

A Combined Use of Intravoxel Incoherent Motion MRI Parameters Can Differentiate Early-Stage Hepatitis-b Fibrotic Livers from Healthy Livers

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Because the nature of the surface of nanoparticles, such as size, charge, and ligands, infl uences the blood circulation half-life, biodistribution and targeting abilities of the particles, much effort has been devoted to the surface modification of nanoparticles. [128][129][130] There is an urgent need to expand studies on the surface modifi cation of NMOFs. Different hydrophilic polymers have been employed to provide small 2015, 11, No.…”

Section: Stability and Surface Modifi Cation Of Nmofsmentioning

confidence: 99%

Metal–Organic Framework‐Based Nanomedicine Platforms for Drug Delivery and Molecular Imaging

Cai

Chu

Liu

et al. 2015

Small

410

198

View full text Add to dashboard Cite

Metal-organic frameworks (MOFs), which are a unique class of hybrid porous materials built from metal ions and organic linkers, have attracted significant research interest in recent years. Compared with conventional porous materials, MOFs exhibit a variety of advantages, including a large surface area, a tunable pore size and shape, an adjustable composition and structure, biodegradability, and versatile functionalities, which enable MOFs to perform as promising platforms for drug delivery, molecular imaging, and theranostic applications. In this article, the recent research progress related to nanoscale metal-organic frameworks (NMOFs) is summarized with a focus on synthesis strategies and drug delivery, molecular imaging, and theranostic applications. The future challenges and opportunities of NMOFs are also discussed in the context of translational medical research. More effort is warranted to develop clinically translatable NMOFs for various applications in nanomedicine.

show abstract

“…Cardiac "self-gated" techniques 21,22 have been proposed to eliminate the need for ECG synchronization by acquiring and processing additional MR signals to derive cardiac cycle timing information resulting in decreased imaging efficiency. These studies have extracted the cardiac self-gating signal from the acquired data during breath-holds [23][24][25] or free-breathing. 19,20,26 Previously reported cardiac self-gating approaches have used the k-space center point 22,27 or center k-space line 5,13,14,23 as navigator signals.…”

Section: Introductionmentioning

confidence: 99%

Free‐breathing cine imaging with motion‐corrected reconstruction at 3T using SPiral Acquisition with Respiratory correction and Cardiac Self‐gating (SPARCS)

Zhou

Yang

Mathew

et al. 2019

Magnetic Resonance in Med

View full text Add to dashboard Cite

Purpose To develop a continuous‐acquisition cardiac self‐gated spiral pulse sequence and a respiratory motion‐compensated reconstruction strategy for free‐breathing cine imaging. Methods Cine data were acquired continuously on a 3T scanner for 8 seconds per slice without ECG gating or breath‐holding, using a golden‐angle gradient echo spiral pulse sequence. Cardiac motion information was extracted by applying principal component analysis on the gridded 8 × 8 k‐space center data. Respiratory motion was corrected by rigid registration on each heartbeat. Images were reconstructed using a low‐rank and sparse (L+S) technique. This strategy was evaluated in 37 healthy subjects and 8 subjects undergoing clinical cardiac MR studies. Image quality was scored (1–5 scale) in a blinded fashion by 2 experienced cardiologists. In 13 subjects with whole‐heart coverage, left ventricular ejection fraction (LVEF) from SPiral Acquisition with Respiratory correction and Cardiac Self‐gating (SPARCS) was compared to that from a standard ECG‐gated breath‐hold balanced steady‐state free precession (bSSFP) cine sequence. Results The self‐gated signal was successfully extracted in all cases and demonstrated close agreement with the acquired ECG signal (mean bias, –0.22 ms). The mean image score across all subjects was 4.0 for reconstruction using the L+S model. There was good agreement between the LVEF derived from SPARCS and the gold‐standard bSSFP technique. Conclusion SPARCS successfully images cardiac function without the need for ECG gating or breath‐holding. With an 8‐second data acquisition per slice, whole‐heart cine images with clinically acceptable spatial and temporal resolution and image quality can be acquired in <90 seconds of free‐breathing acquisition.

show abstract

Prospective cardiac motion self-gating

Cited by 16 publications

References 24 publications

A Combined Use of Intravoxel Incoherent Motion MRI Parameters Can Differentiate Early-Stage Hepatitis-b Fibrotic Livers from Healthy Livers

A Combined Use of Intravoxel Incoherent Motion MRI Parameters Can Differentiate Early-Stage Hepatitis-b Fibrotic Livers from Healthy Livers

Metal–Organic Framework‐Based Nanomedicine Platforms for Drug Delivery and Molecular Imaging

Free‐breathing cine imaging with motion‐corrected reconstruction at 3T using SPiral Acquisition with Respiratory correction and Cardiac Self‐gating (SPARCS)

Contact Info

Product

Resources

About