Prospective Changes in Fasting Glucose Inversely Affects Spexin Levels in Females with Prediabetes

Abstract

BackgroundSpexin (SPX) is a novel peptide thought to have a role in various metabolic regulations. Given its presumed body‐weight regulatory function, we aimed to determine whether lifestyle intervention programs focusing on weight loss and improvement in fasting glucose (FG) among people with impaired glucose regulation also induces changes in circulating levels of SPX.Materials and MethodsA total of 160 Saudi males and females with prediabetes were randomly selected from a larger cohort of 294 who underwent a 6‐month lifestyle modification and/or metformin treatment to improve their glycemic status. Participants were split in two groups based on differences in glucose levels post‐intervention, with the first 50% (improved group) having the most significant reduction in FG. SPX was measured in both time‐points.ResultsChanges in SPX was significant only in this group [baseline median (Q1–Q3) 164pg/ml (136–227) vs follow‐up 176pg/ml (146–285); p<0.01]. When stratified by sex, the significant increase was observed only in females [159pg/ml (127–252) vs 182.5 (152,369.1); p<0.01], not in males. Furthermore, SPX levels showed a significant inverse association with FG (β=−0.22, p=0.003) only in females after adjustment for age and BMI.ConclusionsThe study demonstrated that prospective changes in FG inversely modulates SPX levels in a sexually dimorphic manner.Support or Funding InformationDeanship of Scientific Research, KSU and the Chair for Biomarkers of Chronic Diseases (CBCD), Biochemistry Department, College of Science, King Saud University Association of spexin with glycemic indexes. Fasting glucose (3A), insulin (3B) and HOMA‐IR (3C) on X‐axis and spexin on Y‐axis. Significant inverse correlations between SPX and glycemic indices were seen only in females. “r” depicts pearson correlation coefficient and “p” is the associated p‐value. P‐value <0.05 is considered significantimageAssociation of spexin with glycemic indexes. Fasting glucose (3A), insulin (3B) and HOMA‐IR (3C) on X‐axis and spexin on Y‐axis. Significant inverse correlations between SPX and glycemic indices were seen only in females. “r” depicts pearson correlation coefficient and “p” is the associated p‐value. P‐value <0.05 is considered significantThis abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.