Prospective comparison of transient elastography, Fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C

Liver fibrosis: consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL)

“…However, newer probes are being developed for obese patients or those who have narrow intercostal spaces. Several studies evaluated the accuracy of FibroScan, blood tests, or combinations compared with liver biopsy [34]. Most include patients with HCV infection, one includes patients with chronic liver disease of any origin, one includes patients with biliary cirrhosis due to primary biliary cirrhosis or primary sclerosing cholangitis, and one includes only those patients who are coinfected with HIV and HCV.…”

Non-Invasive Index for Predicting Significant Liver Fibrosis: Comparison of Diagnostic Performances in Patients with Chronic Hepatitis B and C

“…The power of the SF index is strengthened by the fact that the diagnostic performance is improved when using scores in combination, especially direct and indirect fibrosis markers. The GGT, a2MG, and haptoglobin are parameters included in Fibrotest and repeatedly validated as indirect fibrosis markers [10,13,24,25]. Furthermore, MMP2 and TIMP1 have also been frequently reported as useful direct markers [11,26].…”

“…Recently, Wai et al [15] demonstrated that APRI from studies in patients with CHC in predicting liver fibrosis was unlikely to yield accurate results with simple routine laboratory markers in patients with CHB. In contrast to patients with CHB, APRI has been found to be accurate in a wide range of cohorts in patients with CHC [15,23,24]. This might explain why the predictive models included different variables depending on the cause of chronic liver disease.…”

Bayesian prediction for liver fibrosis staging: Combined use of elastography and serum fibrosis markers

“…1,2 Combined use of elastography and fibrosis markers may be a superior method. Algorithms for combined use of serum markers and elastography have been proposed, with specific cut-off values being used in the decision trees.…”

“…We read with much interest the article by Li et al 1 This elegant study indicated that intraportal transplantation of human bone marrow mesenchymal stem cells (hBMSCs) could achieve better liver function recovery and long-term survival in pigs with fulminant hepatic failure (FHF), whereas animals either in the sham group or receiving hBMSCs through the peripheral vein died within 4 days after D-galactosamine injection. We believe that the transplantation procedure was performed immediately after the induction of liver failure according to the title, though interval time between the two interventions was not mentioned clearly in the Materials and Methods section.…”