Prospective evaluation of current asthma control using ACQ and ACT compared with GINA criteria

Korn, Stephanie; Both, Julia; Jung, Matthias; Hübner, Marisa; Taube, Christian; Buhl, Roland

doi:10.1016/j.anai.2011.09.001

Cited by 63 publications

(48 citation statements)

References 27 publications

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“…Several QOL questionnaires have revealed that the results might help to establish the severity of asthma and that modification of the results might correlate with the clinical status of patients (37,38). A study has demonstrated that, in adults with asthma, the QOL is closely related to the frequency of symptoms and the level of pulmonary function (38).…”

Section: Discussionmentioning

confidence: 99%

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Is there an association between postural balance and pulmonary function in adults with asthma?

Almeida¹,

Guimarães²,

Moço³

et al. 2013

Clinics

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OBJECTIVE:Asthma may cause systemic repercussions due to its severity and the effects of treatment. Our objective was to compare posture, balance, functional capacity, and quality of life (QOL) according to the severity of disease, as assessed by pulmonary function levels.METHOD:This cross-sectional study evaluated fifty individuals with asthma. We compared two groups of adult individuals who were divided according to the median of the forced expiratory volume in one second (FEV1) as follows: group A = FEV1>74% predicted; group B = FEV1<74% predicted. All patients underwent the following tests: spirometry, whole-body plethysmography, diffusing capacity for carbon monoxide (DLco), respiratory muscle strength, posture assessment, stabilometry, six-minute walking distance (6MWD), and QOL.RESULTS:All pulmonary function variables exhibited statistically significant differences between the two groups, except for the DLco. The maximal inspiratory pressure (MIP), maximal expiratory pressure (MEP), and 6MWD were lower in group B. The maximal mediolateral velocity and the mediolateral displacement were significantly different, while the postural changes and QOL were similar between the groups.CONCLUSIONS:In adult individuals with asthma, the pulmonary function is associated with balance control in the mediolateral direction but does not influence the postural changes or QOL.

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Section: Discussionmentioning

confidence: 99%

“…A study has demonstrated that, in adults with asthma, the QOL is closely related to the frequency of symptoms and the level of pulmonary function (38). In our investigation, the two groups did not exhibit a significant difference in the median values of the AQLQ.…”

Section: Discussionmentioning

confidence: 99%

Is there an association between postural balance and pulmonary function in adults with asthma?

Almeida¹,

Guimarães²,

Moço³

et al. 2013

Clinics

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“…С другой стороны, полученные результаты пока зывают, что при использовании ACQ 5 системати ческая погрешность в определении уровня контроля практически отсутствует. В целом уровень адекват ных оценок контроля над БА при использовании ACT и ACQ 5 оказался более низким, чем в анало гичных западных исследованиях [26]. Это обстоя тельство нуждается в дальнейшем изучении.…”

Section: Discussionunclassified

Control of bronchial asthma in Russia: results of NIKA multi-center observational study

Архипов¹,

Григорьева²,

Gavrishina³

2011

Pulʹmonologiâ (Mosk.)

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Контроль над бронхиальной астмой (БА) следует рассматривать как главную цель терапии этого забо левания и одновременно как важнейший маркер ка чества оказания медицинской помощи [1]. Первые исследования, в которых оценивался уровень конт роля над БА, были выполнены в США [2] и Запад ной Европе [3] > 10 лет назад. В то время лишь у 5 % пациентов течение БА было контролируемым. Более поздние исследования [4-6] показали, что благодаря изменениям в характере и объеме фармакотерапии БА за последнее 10 летие доля больных с контроли руемым течением этого заболевания увеличилась до 42-49 %. С момента проведения первых исследова ний контроля над БА в российской популяции [7][8][9][10]11] прошло уже > 5 лет. Это достаточно большой срок, который позволяет оценить динамику контро ля над БА и факторы, влияющие на достижение контроля у пациентов в РФ.В конце прошлого 10 летия эксперты Европей ского респираторного (ERS) и Американского тора кального (ATS) обществ пересмотрели концепцию контроля над БА [12]. В результате понятие контроля теперь включает в себя не только оценку симптомов заболевания и показателей спирометрии, но и сни жение потенциального риска, связанного с ухудше нием состояния, развитием обострений, прогрес сированием заболевания, а также с появлением нежелательных лекарственных реакций в ходе лече ния. Расширенной концепции соответствует термин "общий (overall) контроль над БА" [13]. Несмотря на важность оценки общего контроля, исследования, посвященные этой проблеме, в нашей стране не про водились.Еще одной значительной тенденцией последних лет стал поиск новых инструментов для более прос той и точной оценки уровня контроля над БА. Наи более эффективными из них считают опросники, позволяющие выразить контроль в виде композит ного числового показателя. По сравнению с опрос никами, дневники симптомов распространены су щественно меньше. Кроме того, было показано, что оценка дневников, которые больные заполняли в те чение 1-2 нед., требует от врача дополнительного времени, но при этом не может предоставить более Control of bronchial asthma in Russia: results of NIKA multi center observational study Summary Asthma control level was evaluated in 1 000 patients treated in 26 outpatient centers at 12 cities of Russian Federation. Asthma control level was assessed clinically and with special questionnaires ACQ 5 and ACT. Results were referred to GINA criteria. Well controlled asthma was found in 23 % of patients, partly controlled and poorly controlled asthma was diagnosed in 25 % and 42 % of patients, respectively. Attendant physicians mis estimated asthma control level in 49 % of cases. ACQ 5 and ACT questionnaires equally improved estimation of asthma control (64 % and 60 % of adequate estimates, respectively) however, ACT questionnaire demonstrated systematic bias to overestimated asthma control when compared to GINA criteria. Key words: asthma, pharmacoepidemiology, asthma control. РезюмеВ исследовании была проведена оценка уровня контроля над бронхиальной астмой (БА) у 1 000 больных из 26 амбулаторных лечебны...

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“…Cut-off points for controlled and not well-controlled asthma on the full version of the ACQ have also been shown to be suitable for the shortened versions of this instrument (ACQ-5 and ACQ-6) (135). The ability of an ACQ-5 or ACQ-7 score ≥1.5 points and an ACT score ≤19 points to identify uncontrolled asthma was shown in a prospective study of 150 adults with asthma performed in a real-life setting (126). Using these cutoff points, the ACQ-5, ACQ-7 and ACT correctly predicted GINA-defined uncontrolled asthma in 77%, 71% and 81% of patients, respectively.…”

Section: Acq and Actmentioning

confidence: 99%

The Asthma Control Questionnaire as a clinical trial endpoint: past experience and recommendations for future use

Barnes¹,

Casale

Dahl

et al. 2014

Allergy

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The goal of asthma treatment is to control the disease according to guidelines issued by bodies such as the Global Initiative for Asthma. Effective control is dependent upon evaluation of symptoms, initiation of appropriate treatment and minimization of the progressive adverse effects of the disease and its therapies. Although individual outcome measures have been shown to correlate with asthma control, composite endpoints are preferred to enable more accurate and robust monitoring of the health of the individual patient. A number of validated instruments are utilized to capture these component endpoints; however, there is no consensus on the optimal instrument for use in clinical trials. The Asthma Control Questionnaire (ACQ) has been shown to be a valid, reliable instrument that allows accurate and reproducible assessment of asthma control that compares favourably with other commonly used instruments. This analysis provides a summary of the use of ACQ in phase II, III and IV asthma trials. Comparisons between the ACQ and other instruments are also presented. Our analysis suggests that the ACQ is a valid and robust measure for use as a primary or secondary endpoint in future clinical trials.

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Prospective evaluation of current asthma control using ACQ and ACT compared with GINA criteria

Cited by 63 publications

References 27 publications

Is there an association between postural balance and pulmonary function in adults with asthma?

Is there an association between postural balance and pulmonary function in adults with asthma?

Control of bronchial asthma in Russia: results of NIKA multi-center observational study

The Asthma Control Questionnaire as a clinical trial endpoint: past experience and recommendations for future use

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