Prospective evaluation of platelets prepared by single and random methods during 5 days of storage: aspects related to quality and quantity

Effects of platelet concentrate storage time reduction in patients after blood stem cell transplantation

“…Several groups have uniformly shown that the aggregation response was largely reduced during PC storage. This was in particular true in PC at the end of their shelf life on day 4 and 5 leading to the clear recommendation to transfuse fresh PC, as done in our study.…”

“…Notably, a reduced PC storage time may not only improve bacterial safety, but also result in a better preserved platelet function. Several studies have demonstrated a steep decrease in ex vivo platelet function with increasing storage time , which might also translate into reduced clinical efficacy. We therefore studied the efficacy of PC transfusion in two well‐characterized cohorts of patients, receiving PC transfusions before and after the introduction of a reduced PC storage time.…”

Effects of storage duration and volume on the quality of leukoreduced apheresis‐derived platelets: implications for pediatric transfusion medicine

“…However, unlike preservation of metabolic function, PLT aggregation has consistently been shown to decrease over storage in both random-donor and LR-ADP products. [8][9][10][11] While these reports have exclusively used single agonists for PLT function testing, it has been argued that using pairs of agonists during in vitro function testing may optimally recreate in vivo conditions as physiologically PLT aggregation occurs in response to the synergistic action of a combination of agonists at sites of injury. 12,13 As a result, we deliberately decided to use a mixture of ADP and collagen as agonist.…”

Impact of tobacco smoking on platelet function in apheresis products in vitro

“…PCs are generally produced from whole blood preparations (buffy coat) or by apheresis techniques (apheresis‐PCs), which is superior regarding the in vitro haemostatic quality of platelets [1]. It is well known that platelet quality decreases during storage [2]. Moreover, some donor‐related factors (e.g.…”