2018
DOI: 10.1007/s12325-018-0666-4
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Prospective Evaluation of Two iStent® Trabecular Stents, One iStent Supra® Suprachoroidal Stent, and Postoperative Prostaglandin in Refractory Glaucoma: 4-year Outcomes

Abstract: Introduction: This study evaluates long-term outcomes of two trabecular micro-bypass stents, one suprachoroidal stent, and postoperative prostaglandin in eyes with refractory open angle glaucoma (OAG). Methods: Prospective ongoing 5-year study of 80 eligible subjects (70 with 4-year follow-up) with OAG and IOP C 18 mmHg after prior

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Cited by 67 publications
(50 citation statements)
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“…This stent allows circumvention of the damaged trabecular meshwork by creating a direct route from the anterior chamber to Schlemm's canal. Considerable evidence has shown the stents' ability to provide meaningful postoperative reductions in IOP and medication burden for up to 5 years with or without concomitant cataract surgery, and in various subtypes and severities of glaucoma [11][12][13][14][15][16][17]. Moreover, these benefits have occurred with favorable safety and minimal disruption to ocular structures.…”
Section: Introductionmentioning
confidence: 99%
“…This stent allows circumvention of the damaged trabecular meshwork by creating a direct route from the anterior chamber to Schlemm's canal. Considerable evidence has shown the stents' ability to provide meaningful postoperative reductions in IOP and medication burden for up to 5 years with or without concomitant cataract surgery, and in various subtypes and severities of glaucoma [11][12][13][14][15][16][17]. Moreover, these benefits have occurred with favorable safety and minimal disruption to ocular structures.…”
Section: Introductionmentioning
confidence: 99%
“…[32][33][34][35][36] iStent, Trabectome, and Xen had the highest number of prospective studies. There were 29 prospective studies of the iStent (25 iStent, 3 iStent inject, 62-64 1 iStent +Supra), 65 with quality scores ranging from −1 to 5. There were 16 prospective studies of the Trabectome, [66][67][68][69][70][71][72][73][74][75][76][77][78][79][80][81] but many described the outcomes of patients who had Trabectome using data from the Trabectome Database; thus, while the data were collected prospectively, the research questions were asked retrospectively, and many of these studies had lower quality scores based on lack of control group.…”
Section: Resultsmentioning
confidence: 99%
“…Although of interest in clinical practice, scant studies have accessed the role of combining MIGS [54], and only limited evidence is available to demonstrate whether combining MIGS is additive with respect to IOP control [55]. In our experience, ECP can be combined with outflow-targeted procedures such as KDB goniotomy to optimize IOP reduction, and this can be done cautiously but successfully in eyes with severe disease for whom the alternative might be incisional surgery.…”
Section: Combination Migsmentioning
confidence: 96%