Prospective Markers for Early Diagnosis and Prognosis of Sporadic Pancreatic Ductal Adenocarcinoma

Tobi, Martin; Kim, Mijin; Weinstein, Douglas; Rambus, Mary Ann; Hatfield, James S.; Adsay, Volkan; Levi, Edi; Evans, Douglas B.; Lawson, Michael J.; Fligiel, Suzanne E. G.

doi:10.1007/s10620-012-2387-x

Cited by 16 publications

(13 citation statements)

References 32 publications

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“…26,27 Polymorphisms of HBD-1 and HBD-2 have been associated with severe acute pancreatitis, 28 and the detection of human defensin α 5 (HAD-5) in pancreatic metaplasia has been seen as an indicator of the adenoma-carcinoma sequence. 29 In the present study, HNP-1 was found to be expressed at a significantly higher level in malignant human pancreatic tissue than in healthy pancreas or in CP. These findings support the hypothesis that defensins, in particular HNP-1, may represent an important link between chronic inflammation and malignant transformation in the pancreas.…”

Section: Discussionsupporting

confidence: 49%

“…26,27 Likewise, severe acute pancreatitis has been associated with polymorphisms of defensin genes, 28 and defensins have been detected in pancreatic metaplasia. 29 We assume that disturbances of the regulative function of defensins, possibly triggered by chronic inflammation, could promote malignant transformation and tumor growth within the pancreas. During the inflammatory process, defensins may either be switched off or the cancer may abuse their functions.…”

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confidence: 99%

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Antimicrobial Peptide Human Neutrophil Peptide 1 as a Potential Link Between Chronic Inflammation and Ductal Adenocarcinoma of the Pancreas

Pausch¹,

Adolph²,

Felix³

et al. 2018

Pancreas

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Section: Discussionsupporting

confidence: 49%

mentioning

confidence: 99%

Antimicrobial Peptide Human Neutrophil Peptide 1 as a Potential Link Between Chronic Inflammation and Ductal Adenocarcinoma of the Pancreas

Pausch¹,

Adolph²,

Felix³

et al. 2018

Pancreas

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“…Adnab-9: Adnab-9 is a murine monoclonal antibody that has previously been implicated in the diagnosis of gastrointestinal tumors[ 448 , 449 ]. Adnab-9 detection in stools has a sensitivity and specificity of 80% and 87% for detection PC[ 450 , 451 ].…”

Section: Faecal Biomarkersmentioning

confidence: 99%

Biomarkers in the diagnosis of pancreatic cancer: Are we closer to finding the golden ticket?

O’Neill

Stoita

2021

WJG

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Pancreatic cancer (PC) is a leading cause of cancer related mortality on a global scale. The disease itself is associated with a dismal prognosis, partly due to its silent nature resulting in patients presenting with advanced disease at the time of diagnosis. To combat this, there has been an explosion in the last decade of potential candidate biomarkers in the research setting in the hope that a diagnostic biomarker may provide a glimmer of hope in what is otherwise quite a substantial clinical dilemma. Currently, serum carbohydrate antigen 19-9 is utilized in the diagnostic work-up of patients diagnosed with PC however this biomarker lacks the sensitivity and specificity associated with a gold-standard marker. In the search for a biomarker that is both sensitive and specific for the diagnosis of PC, there has been a paradigm shift towards a focus on liquid biopsy and the use of diagnostic panels which has subsequently proved to have efficacy in the diagnosis of PC. Currently, promising developments in the field of early detection on PC using diagnostic biomarkers include the detection of microRNA (miRNA) in serum and circulating tumour cells. Both these modalities, although in their infancy and yet to be widely accepted into routine clinical practice, possess merit in the early detection of PC. We reviewed over 300 biomarkers with the aim to provide an in-depth summary of the current state-of-play regarding diagnostic biomarkers in PC (serum, urinary, salivary, faecal, pancreatic juice and biliary fluid).

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“…The presence of Adnab-9 in stools has been shown to be associated with PC precursor lesions. As a fecal biomarker, Adnab-9 has a sensitivity of 80% and a specificity of 87% for the detection of PC [ 25 ]. In the future, effective tumor markers can be used to aid in the diagnosis of the presymptomatic PC, treatment assessment, and then monitoring for disease recurrence.…”

Section: Diagnosis and Stagingmentioning

confidence: 99%

Pancreatic Cancer Epidemiology, Detection, and Management

Zhang

Zeng

Chen

et al. 2016

Gastroenterology Research and Practice

148

116

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PC (pancreatic cancer) is the fourth most common cause of death due to cancer worldwide. The incidence and mortality rates have been increasing year by year worldwide, and this review has analyzed the most recent incidence and mortality data for pancreatic cancer occurrence in China. Several possible risk factors have been discussed here, involving known established risk factors and novel possible risk factors. The development of this cancer is a stepwise progression through intraepithelial neoplasia to carcinoma. Though early and accurate diagnosis is promising based on a combination of recent techniques including tumor markers and imaging modalities, lacking early clinical symptoms makes the diagnosis late. Correct staging is critical because treatment is generally based on this parameter. Treatment options have improved throughout the last decades. However, surgical excision remains the primary therapy and efficacy of conventional chemoradiotherapy for PC is limited. Recently, some novel new therapies have been developed and will be applied in clinics soon. This review will provide an overview of pancreatic cancer, including an understanding of the developments and controversies.

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Prospective Markers for Early Diagnosis and Prognosis of Sporadic Pancreatic Ductal Adenocarcinoma

Abstract: Our study suggests that Adnab-9 may be an effective marker for diagnosis and prognosis of PDA. Adnab-9 may be reflective of the presence of Paneth cells confirmed by Defensin-5 staining. These cells may modulate the biological activity of the cancer and confer a better prognosis.

Cited by 16 publications

References 32 publications

Antimicrobial Peptide Human Neutrophil Peptide 1 as a Potential Link Between Chronic Inflammation and Ductal Adenocarcinoma of the Pancreas

Antimicrobial Peptide Human Neutrophil Peptide 1 as a Potential Link Between Chronic Inflammation and Ductal Adenocarcinoma of the Pancreas

Biomarkers in the diagnosis of pancreatic cancer: Are we closer to finding the golden ticket?

Pancreatic Cancer Epidemiology, Detection, and Management

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