Prospective Memory Influences Social Functioning in People With First-Episode Schizophrenia

Lui, Simon; Zhang, Ruiting; Lau, Wing-Cheong; Liu, Amy C.Y.; Chui, William W.H.; Wang, Ya; Tsang, Kirby C.M.; Yeung, Hera K.H.; Cheung, Eric F. C.; Chan, Raymond C.K.

doi:10.4088/jcp.21m14114

Cited by 6 publications

(5 citation statements)

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“…Our observations about the central role of neurocognition in shaping functional capacity are in agreement with the prior studies. For instance, a prospective study of individuals with FEP, based on a network analysis, revealed that working memory appears to have the highest centrality in predicting social functioning (30). Another cross-sectional study of stable outpatients with schizophrenia demonstrated that working memory de cits measured using the letter number sequencing task were among the most central nodes predicting social functioning (31).…”

Section: Discussionmentioning

confidence: 99%

Assessment of interrelationships between cognitive performance, symptomatic manifestation and social functioning in the acute and clinical stability phase of schizophrenia: Insights from a network analysis

Misiak

Piotrowski

Samochowiec

2023

Preprint

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Background: It has been shown that various aspects of clinical manifestation of schizophrenia are strongly related to social functioning. However, it remains unknown as to whether similar factors predict social functioning at various stages of psychosis. Therefore, the present study aimed to compare the effects of interconnections between various domains of psychopathology and neurocognition on social functioning in people during acute phase of psychosis and those during remission of positive and disorganization symptoms using a network analysis. Methods: Two independent samples of individuals with schizophrenia spectrum disorders were enrolled (n = 208). Clinical assessment covered the levels of functioning, positive, negative and depressive symptoms. Cognition was recorded using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Results: Both networks did not differ significantly on the majority of network comparison tests, except of significantly higher strength centrality of negative symptoms in participants during clinical stability. In both networks, the majority of centrality metrics had the highest values for the RBANS attention score that is a sum of scores from two tasks (digit span and coding). In both networks, social functioning was directly connected to positive, negative and depressive symptoms as well as the RBANS scores of attention and language. Conclusions: Findings from the present study indicate the central role of cognitive deficits, especially those related to attention, processing speed, and working memory in shaping functional impairments regardless of schizophrenia phase. Therapeutic interventions that aim to improve functional capacity need to target these domains of neurocognitive performance.

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Section: Discussionmentioning

confidence: 99%

Assessment of interrelationships between cognitive performance, symptomatic manifestation and social functioning in the acute and clinical stability phase of schizophrenia: Insights from a network analysis

Misiak

Piotrowski

Samochowiec

2023

Preprint

View full text Add to dashboard Cite

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“…Our observations about the central role of neurocognition in shaping functional capacity are in agreement with the prior studies. For instance, a prospective study of individuals with FEP, based on a network analysis, revealed that working memory appears to have the highest centrality in predicting social functioning [ 41 ]. Another cross-sectional study of stable outpatients with schizophrenia demonstrated that working memory deficits measured using the letter number sequencing task were among the most central nodes predicting social functioning [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

Assessment of interrelationships between cognitive performance, symptomatic manifestation and social functioning in the acute and clinical stability phase of schizophrenia: insights from a network analysis

Misiak,

Piotrowski,

Samochowiec

2023

BMC Psychiatry

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Background It has been shown that various aspects of clinical manifestation of schizophrenia are strongly related to social functioning. However, it remains unknown as to whether similar factors predict social functioning at various stages of psychosis. Therefore, the present study aimed to compare the effects of interconnections between various domains of psychopathology and neurocognition on social functioning in people during acute phase of psychosis and those during remission of positive and disorganization symptoms using a network analysis. Methods Two independent samples of individuals with schizophrenia spectrum disorders were enrolled (89 inpatients during acute phase and 90 outpatients during remission of positive and disorganization symptoms). Clinical assessment covered the levels of functioning, positive, negative and depressive symptoms. Cognition was recorded using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Data were analyzed by means of the network analysis. Two separate networks of clinical symptoms, social functioning, and cognition (i.e., in patients during acute phase of psychosis and remitted outpatients with schizophrenia) were analyzed and compared with respect to the measures of centrality (betweenness, closeness, strength, and expected influence) and edge weights. Results In both networks, the majority of centrality metrics (expected influence, strength, and closeness) had the highest values for the RBANS scores of attention (the sum of scores from two tasks, i.e., digit span and coding) and immediate memory. In both networks, social functioning was directly connected to positive, negative and depressive symptoms as well as the RBANS scores of attention and language. Additionally, in remitted patients, social functioning was directly connected to the RBANS score of immediate memory. Conclusions Findings from the present study indicate the central role of cognitive deficits, especially those related to attention, processing speed, working and immediate memory in shaping functional impairments regardless of schizophrenia phase. Therapeutic interventions that aim to improve functional capacity need to target these domains of neurocognitive performance.

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“…This study has been approved by the New Territories West Cluster Research Ethics Committee (Protocol number: NTWC/CREC/823/10; NTWC/CREC/1293/14; UW14-325). The participants of this study have completed additional assessments (including endophenotyping using behavioural and neuroimaging measures), and the findings have been reported elsewhere (Cheung et al, 2015;Chiu et al, 2018;Deng et al, 2019;Lui et al, 2022Lui et al, , 2021Lui et al, , 2016Lui et al, , 2015.…”

Section: Participantsmentioning

confidence: 92%

Pathway-Specific Polygenic Scores Improve Cross-Ancestry Prediction of Psychosis and Clinical Outcomes

Tubbs,

Leung,

Zhong

et al. 2023

Preprint

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Psychotic disorders are debilitating conditions with disproportionately high public health burden. Genetic studies indicate high heritability, but current polygenic scores (PGS) account for only a fraction of variance in psychosis risk. PGS often show poor portability across ancestries, performing significantly worse in non-European populations. Pathway-specific PGS (pPGS), which restrict PGS to genomic locations within distinct biological units, could lead to increased mechanistic understanding of pathways that lead to risk and improve cross-ancestry prediction by reducing noise in genetic predictors. This study examined the predictive power of genome-wide PGS and nine pathway-specific pPGS in a unique Chinese-ancestry sample of deeply-phenotyped psychosis patients and non-psychiatric controls. We found strong evidence for the involvement of schizophrenia-associated risk variants within ”nervous system development” (p=2.5e-4) and ”regulation of neuron differentiation” pathways (p=3.0e-4) in predicting risk for psychosis. We also found the “ion channel complex” pPGS, with weights derived from GWAS of bipolar disorder, to be strongly associated with the number of inpatient psychiatry admissions a patient experiences (p=1.5e-3) and account for a majority of the signal in the overall bipolar PGS. Importantly, although the schizophrenia genome-wide PGS alone explained only 3.7% of the variance in liability to psychosis in this Chinese ancestry sample, the addition of the schizophrenia-weighted pPGS for “nervous system development” and “regulation of neuron differentiation” increased the variance explained to 6.9%, which is on-par with the predictive power of PGS in European ancestry samples. Thus, not only can pPGS provide greater insight into mechanisms underlying genetic risk for disease and clinical outcomes, but may also improve cross-ancestry risk prediction accuracy.

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Prospective Memory Influences Social Functioning in People With First-Episode Schizophrenia

Cited by 6 publications

References 0 publications

Assessment of interrelationships between cognitive performance, symptomatic manifestation and social functioning in the acute and clinical stability phase of schizophrenia: Insights from a network analysis

Assessment of interrelationships between cognitive performance, symptomatic manifestation and social functioning in the acute and clinical stability phase of schizophrenia: Insights from a network analysis

Assessment of interrelationships between cognitive performance, symptomatic manifestation and social functioning in the acute and clinical stability phase of schizophrenia: insights from a network analysis

Pathway-Specific Polygenic Scores Improve Cross-Ancestry Prediction of Psychosis and Clinical Outcomes

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