Prospective, multi-centre, randomised evaluation of the safety and efficacy of five dosing regimens of viscosupplementation with hylan G-F 20 in patients with symptomatic tibio-femoral osteoarthritis: a pilot study

Conrozier, Thierry; Jerosch, Jörg; Beks, P.J.; Kemper, F; Euller-Ziegler, L.; Bailleul, François; Chevalier, Xavier

doi:10.1007/s00402-008-0601-2

Cited by 63 publications

(60 citation statements)

References 17 publications

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“…In general, while CSs have shown to be more effective (especially on pain control) in the short term (<1 month), better results have been reported with HA at subsequent evaluations, providing only a moderate effect after 26 weeks (8,12,17,(33)(34)(35)(36)(37)(38)(39). Furthermore, the efficacy of repeated injections of HA, after a previous course of either HA or CSs, has also been proved (37,40). However, other studies neglected the efficacy of HA (41-44), reporting only small or no differences compared with CSs.…”

Section: Rationale: Css Vs Hamentioning

confidence: 93%

“…Furthermore, HA is considered safe also after a previous course of HA injections (35,37,40). Despite this evidence, the safety profile of intra-articular HA injections has recently been questioned (43).…”

Section: Adverse Events and Safetymentioning

confidence: 99%

“…HA is generally considered safe compared to CSs or saline (17,35,(40)(41)(42)52). Furthermore, HA is considered safe also after a previous course of HA injections (35,37,40).…”

Section: Adverse Events and Safetymentioning

confidence: 99%

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Hyaluronic acid vs corticosteroids in symptomatic knee osteoarthritis: a mini-review of the literature

Bisicchia

Tudisco

2017

ccmbm

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SummaryIntroduction. Although intra-articular injections of hyaluronic acid (HA) are common non-operative measures used in clinical practice in the management of symptomatic osteoarthritis, there is a great controversy on their efficacy and safety compared to corticosteroids (CSs). Efficacy. Conflicting results have been reported in clinical trials and meta-analysis due to methodological differences in study design, along with collection, analysis, and interpretation of data. Even if some studies reported small or no differences of HA compared with CSs (or inferred that HA is not more effective than saline as a placebo), in general CSs have shown to be superior in the short term (especially on pain control), while better results have been reported with HA at subsequent evaluations, but with only a moderate effect after 26 weeks. Safety. Mild or moderate adverse events have generally been reported after HA injections, the most common being injection site pain. HA is generally considered safe compared to CSs or saline. Furthermore, HA has shown to be safe also after a previous course of injections. Conclusions. Conflicting results have been reported on the efficacy and safety of HA. Guidelines are controversial and in most of the cases "uncertain" recommendations are provided due to inconclusive evidence in literature. However, HA does not seem to have significantly higher side effects when compared to saline or CSs injections, and provides better medium-term control of symptoms in patients with mild to moderate knee osteoarthritis.

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Section: Rationale: Css Vs Hamentioning

confidence: 93%

Section: Adverse Events and Safetymentioning

confidence: 99%

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Hyaluronic acid vs corticosteroids in symptomatic knee osteoarthritis: a mini-review of the literature

Bisicchia

Tudisco

2017

ccmbm

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“…Переносимость лечения в группах не различалась. При сравнении двух режи-мов введения гилана G-F 20 -однократное введение 6 мл и трехкратное введение по 2 мл 1 раз в неделю [53] -показано, что однократное введение препарата может быть столь же эффективным и переносимым, как и трехкратное.…”

Section: ответ на терапию нет ответа на терапиюunclassified

The 2014 guidelines for the management of osteoarthritis: Place of hyaluronic acid preparations

Чичасова¹,

Имаметдинова²

2015

RJTAO

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Остеоартроз (ОА) -хроническое заболевание суставов, приводящее к разрушению суставного хряща, образованию центральных и краевых остеофитов, деформациям и нару-шению функции, чрезвычайно распространен в популяции, особенно у лиц старше 60 лет. По разным данным, распро-страненность ОА в популяции составляет 10-12% [1], при-чем у четверти пациентов имеются явные нарушения функ-ции. Риск инвалидизации при гонартрозе выше, чем при

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“…Another prospective, randomized trial performed by Conrozier et al 18 demonstrated the efficacy and safety of a single 6 mL injection of hylan G-F 20, in a comparison of different dosing regimens in the treatment of knee osteoarthritis. This study suggests that a single 6 mL injection of hylan G-F 20 may be as efficacious and as well tolerated as 3 × 2 mL injections given one week apart.…”

mentioning

confidence: 99%

Treatment of osteoarthritis knee pain: update on use of intra-articular hylan G-F 20

Migliore¹

2010

ORR

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Background: Osteoarthritis is a public health concern, particularly in modern society, and is the leading osteoarticular pathology in developed countries. The increased prevalence of osteoarthritis with aging, coupled with the aging of populations, makes osteoarthritis a high priority health care problem. Viscosupplementation is a well established treatment option in knee osteoarthritis that is included in the professional guidelines for treatment of this joint disease. Objective: This review assessed the efficacy and safety of viscosupplementation with hylan G-F 20 (Synvisc ® ) in the management of joint pain in knee osteoarthritis. Methods: Three databases were searched, ie, Medline (1970Medline ( -2010, the Database of Abstract on Reviews and Effectiveness, and the Cochrane Database of Systematic Reviews. Reference lists of relevant articles were examined for additional references. Results: Eighteen studies were identified (six European, five Turkish, three US, two Canadian, one Swiss and one English), which reported efficacy of viscosupplementation in a total of 3689 patients undergoing viscosupplementation treatment with Synvisc for knee osteoarthritis compared with low molecular weight viscosupplementation, high molecular weight viscosupplementation, medium molecular weight viscosupplementation, placebo, corticosteroids, nonsteroidal anti-inflammatory drugs, and physical therapy. Conclusion: Synvisc viscosupplementation in the treatment of knee osteoarthritis is a safe and effective therapeutic option that could also reduce the direct and indirect costs related to this disease.

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Prospective, multi-centre, randomised evaluation of the safety and efficacy of five dosing regimens of viscosupplementation with hylan G-F 20 in patients with symptomatic tibio-femoral osteoarthritis: a pilot study

Cited by 63 publications

References 17 publications

Hyaluronic acid vs corticosteroids in symptomatic knee osteoarthritis: a mini-review of the literature

Hyaluronic acid vs corticosteroids in symptomatic knee osteoarthritis: a mini-review of the literature

The 2014 guidelines for the management of osteoarthritis: Place of hyaluronic acid preparations

Treatment of osteoarthritis knee pain: update on use of intra-articular hylan G-F 20

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