Prospective, Multicenter Evaluation of Highly Concentrated Fibrin Glue in the Treatment of Complex Cryptogenic Perianal Fistulas

Zmora, Oded; Neufeld, David; Ziv, Yehiel; Tulchinsky, Hagit; Scott, Dan; Khaikin, Marat; Stepansky, Albert; Rabau, Micha; Koller, Moshe

doi:10.1007/s10350-005-0199-1

Cited by 57 publications

(37 citation statements)

References 20 publications

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“…Overall, the recurrence rate in our study was 30%, which was similar to the recurrence rates in the studies of Zmora et al, [8], Sentovich et al, [11],Chan et al, [7] and Cintron et al, [10] [Table/ Fig-5]. …”

Section: Resultssupporting

confidence: 89%

“…The mean age (48.5 years) in our study was similar to that in the studies of Chan et al, [7] and Zmora et al, [8].…”

Section: Discussionsupporting

confidence: 91%

“…Zmora et al, [8], in his study, reported that a 75% recurrence occurred within 1 month and that a 89% recurrence occurred within 2 months of the procedure. In our study, only 1 patient who appeared to be healed at 3 months, showed a discharge at 6 months of follow up, there by proving that the maximum recurrence occurred before 6 months.…”

Section: Resultsmentioning

confidence: 87%

“…If a failure occurs after 1 attempt, then the patient should be offered various surgical options. In few studies, healing rates of 25% (Zmora et al, [8]) and 80% (Lindsey et al, [19] were noticed, after regluing, probably because of some technical flaws during the first attempt. If the technique is standardized and a learning curve is achieved, there should be no reason for a patient of fistula in ano, to have any different result after regluing as compared to that in the 1 st attempt.…”

Section: Resultsmentioning

confidence: 99%

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The Role of Fibrin Glue in the Treatment of High and Low Fistulas in Ano

Mishra¹

2013

JCDR

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Section: Resultssupporting

confidence: 89%

“…The mean age (48.5 years) in our study was similar to that in the studies of Chan et al, [7] and Zmora et al, [8].…”

Section: Discussionsupporting

confidence: 91%

Section: Resultsmentioning

confidence: 87%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

The Role of Fibrin Glue in the Treatment of High and Low Fistulas in Ano

Mishra¹

2013

JCDR

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“…Recentemente, foi realizado um estudo prospectivo multicêntrico, envolvendo sessenta pacientes portadores de fístulas anais complexas de origem criptogênica 6 . Os pacientes recebiam preparo intestinal com fosfato sódico, na véspera do procedimento, assim como antibioticoterapia profilática, com cefonicid (1 g) e metronidazol (500 mg), administrados antes da indução da anestesia.…”

Section: Atualização _______________________ ________________________unclassified

O emprego da cola de fibrina no tratamento das fístulas anais

Lopes-Paulo

2006

Rev bras. colo-proctol.

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O emprego de cola de fibrina no tratamento de fístulas anais tem sido relatado em diversos estudos, com a finalidade de obliterar o trajeto fistuloso, criando uma matriz para sua cicatrização definitiva. O método consiste na curetagem e lavagem do trajeto fistuloso, seguidas pela injeção da cola. Esse procedimento pode ser associado ao avanço de retalhos endorretais ou outros métodos para obliteração do orifício interno, o que pode aumentar sua eficácia. Os índices de cicatrização descritos variam de 30 a 50 % em média. A sua utilização não prejudica a realização de outros procedimentos, em caso de insucesso, o que pode torná-lo uma opção para o tratamento inicial das fístulas anais.

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Surgical intervention for anorectal fistula

Jacob

Perakath

Keighley³

2010

Cochrane Database of Systematic Reviews

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BACKGROUND: Surgery for anorectal fistula may result in recurrence, or impairment of continence. The ideal treatment for anorectal fistulae should be associated with low recurrence rates, minimal incontinence and good quality of life.OBJECTIVE: To assess the efficacy and morbidity of operative procedures for chronic anal fistula, primary outcomes being recurrence and incontinence. SELECTION CRITERIA: Randomised controlled trials comparing operative procedures for anorectal fistulae were considered. Non randomised trials and cohort studies were examined where data on recurrence and function were available. CRITERIA FOR CONSIDERING STUDIES FOR THIS RE-DATA COLLECTION AND ANALYSIS: Two reviewers (TJ and BP) independently selected the trials for inclusion in the review. Disagreements were solved by discussion. Where disagreement persisted and published results made data extraction difficult, we obtained clarification from the authors. REVMAN 5 was used for statistical analysis. Quality of the trials were assessed and allowances made for subgroup analysis and prevention of publication bias, using funnel plots if needed.MAIN RESULTS: Ten randomized controlled trials were available for analysis. The quality of included studies was adequate, though in some trials the numbers were small and they were inadequately powered for equivalence or to detect significant differences. Comparisons were made between various modalities of treatments. There were no significant difference in recurrence rates or incontinence rates in any of the studied comparisons except in the case of advancement flaps. There were more recurrences in the glue plus flap group, a significant difference that favoured the flap only technique. It was also noted that Fibrin glue and advancement flap procedures report low incontinence rates. In the review of literature of non-randomized trials, most trials on fibrin glue indicate good healing in simple fistulae with low incontinence rates. AUTHORS' CONCLUSIONS:There are very few randomized controlled trials comparing the various modalities of surgery for fistula in ano. While post operative pain, time to healing and discharge

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Prospective, Multicenter Evaluation of Highly Concentrated Fibrin Glue in the Treatment of Complex Cryptogenic Perianal Fistulas

Abstract: Injection of fibrin glue for the treatment of perianal fistulas is safe, simple, and associated with early return to normal activity. Although moderately successful, it may preclude extensive surgery in more than one-half of these patients.

Cited by 57 publications

References 20 publications

The Role of Fibrin Glue in the Treatment of High and Low Fistulas in Ano

The Role of Fibrin Glue in the Treatment of High and Low Fistulas in Ano

O emprego da cola de fibrina no tratamento das fístulas anais

Surgical intervention for anorectal fistula

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