Prospective multicenter survey for Nursing and Healthcare-associated Pneumonia in Japan

Imamura, Yoshifumi; Miyazaki, Taiga; Watanabe, Akira; Tsukada, Hiroki; Nagai, Hirokazu; Hasegawa, Yoshinori; Tomono, Kazunori; Ito, Isao; Teramoto, Shinji; Ishida, Tadashi; Kadota, Jun‐ichi; Kohno, Shigeru; Mukae, Hiroshi

doi:10.1016/j.jiac.2022.03.030

Cited by 11 publications

(9 citation statements)

References 20 publications

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“…In contrast, the NHCAP category will likely continue to be used in Japan, because of the significant differences in the medical care systems of Japan and the West [10]. Japanese multicenter prospective studies of NHCAP patients showed that most NHCAP patients were elderly and terminal state patients, indicating the need for consideration of both medical and ethical aspects when deciding treatment plans for pneumonia [30].…”

Section: Tablementioning

confidence: 99%

Comparative study of bacterial flora in bronchoalveolar lavage fluid of pneumonia patients based on their pneumonia subtypes and comorbidities using 16S ribosomal RNA gene analysis

Nemoto

Yatera

Akata

et al. 2022

Journal of Infection and Chemotherapy

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Section: Tablementioning

confidence: 99%

Comparative study of bacterial flora in bronchoalveolar lavage fluid of pneumonia patients based on their pneumonia subtypes and comorbidities using 16S ribosomal RNA gene analysis

Nemoto

Yatera

Akata

et al. 2022

Journal of Infection and Chemotherapy

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“…The characteristics of the included studies are shown in Table 2 . Among these 21 studies, five 6 , 13 , 18 , 30 , 36 and 16 4 , 7 , 14 , 19 , 31 – 35 , 37 – 43 were prospective and retrospective studies, respectively. The category of pneumonia was eight 7 , 19 , 31 , 33 , 36 , 38 , 39 , 42 , seven 13 , 18 , 32 , 34 , 35 , 41 , 43 , and six 4 , 6 , 14 , 30 , 37 , 40 for HCAP, NHCAP, and NHAP, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…5.4 software. In eight studies 14 , 18 , 30 – 35 where AUC was not described in the paper, the AUC was calculated based on the receiver operator characteristic (ROC) curves that were obtained from the raw data of the number of patients and fatalities for each severity grade using STATA 14 software. Statistical significance was set at a p -value of < 0.05.…”

Section: Methodsmentioning

confidence: 99%

Utility of pneumonia severity assessment tools for mortality prediction in healthcare-associated pneumonia: a systematic review and meta-analysis

Noguchi,

Katsurada,

Yatera

et al. 2024

Sci Rep

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Accurate prognostic tools for mortality in patients with healthcare-associated pneumonia (HCAP) are needed to provide appropriate medical care, but the efficacy for mortality prediction of tools like PSI, A-DROP, I-ROAD, and CURB-65, widely used for predicting mortality in community-acquired and hospital-acquired pneumonia cases, remains controversial. In this study, we conducted a systematic review and meta-analysis using PubMed, Cochrane Library (trials), and Ichushi web database (accessed on August 22, 2022). We identified articles evaluating either PSI, A-DROP, I-ROAD, or CURB-65 and the mortality outcome in patients with HCAP, and calculated the pooled sensitivities, specificities, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and the summary area under the curves (AUCs) for mortality prediction. Additionally, the differences in predicting prognosis among these four assessment tools were evaluated using overall AUCs pooled from AUC values reported in included studies. Eventually, 21 articles were included and these quality assessments were evaluated by QUADAS-2. Using a cut-off value of moderate in patients with HCAP, the range of pooled sensitivity, specificity, PLR, NLR, and DOR were found to be 0.91–0.97, 0.15–0.44, 1.14–1.66, 0.18–0.33, and 3.86–9.32, respectively. Upon using a cut-off value of severe in those patients, the range of pooled sensitivity, specificity, PLR, NLR, and DOR were 0.63–0.70, 0.54–0.66, 1.50–2.03, 0.47–0.58, and 2.66–4.32, respectively. Overall AUCs were 0.70 (0.68–0.72), 0.70 (0.63–0.76), 0.68 (0.64–0.73), and 0.67 (0.63–0.71), respectively, for PSI, A-DROP, I-ROAD, and CURB-65 (p = 0.66). In conclusion, these severity assessment tools do not have enough ability to predict mortality in HCAP patients. Furthermore, there are no significant differences in predictive performance among these four severity assessment tools.

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“…Older adults with medical comorbidities had an increased incidence of community- and hospital-acquired pneumonia. 36 37 In older adults and people with disabilities, swallowing dysfunction is a risk factors for pneumonia. 38 39 Previous studies have suggested that the swallowing function significantly changes with age due to decreased oropharyngeal skeletal muscle strength and reduced peristalsis, which requires multiple swallowing.…”

Section: Discussionmentioning

confidence: 99%

The Association Between Antihypertensive Drug Use and Hospitalization for Pneumonia in the General Population: A Case-Crossover Study Using the National Health Insurance Database of Korea

et al. 2022

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Background Previous studies have reported an association between pneumonia risk and the use of certain drugs. We investigated the relationship between antihypertensive drugs and pneumonia in the general population. Methods This case-crossover study utilized the nationwide data of South Korea. We included participants who were hospitalized for pneumonia. A single case period was defined as 30 days before pneumonia onset, and two control periods were established (90–120 and 150–180 days before pneumonia onset). Further, we performed sensitivity and subgroup analyses (according to the presence of diabetes, documented disability, and whether participants were aged ≥ 70 years). We used conditional logistic regression models adjusted for covariates, such as angiotensin-converting-enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), other antihypertensives, statins, antipsychotics, benzodiazepine, and the number of outpatient visits. Results In total, 15,463 subjects were included in this study. ACE inhibitors (adjusted odds ratio [aOR], 0.660; 95% confidence interval [CI], 0.558–0.781), ARBs (aOR, 0.702; 95% CI, 0.640–0.770), and other antihypertensive drugs (aOR, 0.737; 95% CI, 0.665–0.816) were significantly associated with reduced pneumonia risk. Subgroup analyses according to the presence of diabetes mellitus, documented disability, and whether participants were aged ≥ 70 years consistently showed the association of antihypertensives with a reduced risk of hospitalization for pneumonia. Conclusion All antihypertensive drug types were related to a lower risk of hospitalization for pneumonia in the general population. Our results implied that frequent medical service usage and protective immunity were primarily related to a reduced risk of pneumonia in the general population of South Korea.

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Prospective multicenter survey for Nursing and Healthcare-associated Pneumonia in Japan

Cited by 11 publications

References 20 publications

Comparative study of bacterial flora in bronchoalveolar lavage fluid of pneumonia patients based on their pneumonia subtypes and comorbidities using 16S ribosomal RNA gene analysis

Comparative study of bacterial flora in bronchoalveolar lavage fluid of pneumonia patients based on their pneumonia subtypes and comorbidities using 16S ribosomal RNA gene analysis

Utility of pneumonia severity assessment tools for mortality prediction in healthcare-associated pneumonia: a systematic review and meta-analysis

The Association Between Antihypertensive Drug Use and Hospitalization for Pneumonia in the General Population: A Case-Crossover Study Using the National Health Insurance Database of Korea

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