Prospective multiparametric CMR characterization and MicroRNA profiling of anthracycline cardiotoxicity: A pilot translational study

Harries, Iwan; Biglino, Giovanni; Ford, K L; Nelson, Martin; Rego, Gui; Srivastava, Prashant K.; Williams, Mark; Berlot, B; Gárate, Estefania De; Baritussio, Anna; Liang, Kate; Baquedano, Mai; Chavda, Nikesh; Lawton, Christopher; Shearn, Andrew I U; Otton, Sophie; Lowry, Lisa; Nightingale, Angus; Plana, Juan Carlos; Marks, David; Emmanueli, Costanza; Bucciarelli-Ducci, Chiara

doi:10.1016/j.ijcha.2022.101134

Cited by 4 publications

(4 citation statements)

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“… 55 Additionally, increased miR-181a-3p levels at baseline, before the start of chemotherapy, were associated with less LVEF recovery 6 months after the end of treatment in adults. 57 Moreover, in adult patients with breast cancer, a decline in miR-181b/c levels was associated with a rise in cTnI and/or cTnT. 49 …”

Section: Circulating Mirna In Response To Anthracyclines In Patientsmentioning

confidence: 99%

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Circulating MicroRNA as Biomarkers of Anthracycline-Induced Cardiotoxicity

Boen,

Cherubin,

Franssen

et al. 2024

JACC: CardioOncology

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Section: Circulating Mirna In Response To Anthracyclines In Patientsmentioning

confidence: 99%

“… 55 In adults with lymphoma, miR-221-3p was reduced at baseline in patients with poor recovery of LVEF after the end of DOX treatment, compared to those with good recovery. 57 …”

Section: Circulating Mirna In Response To Anthracyclines In Patientsmentioning

confidence: 99%

Circulating MicroRNA as Biomarkers of Anthracycline-Induced Cardiotoxicity

Boen,

Cherubin,

Franssen

et al. 2024

JACC: CardioOncology

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“…Clinical CMR results, when combined with biomarkers such as cTn and NPs, can enhance risk stratification [108] and enable observations of cardiac tissue structure. Harries et al [109] conducted a study on 24 patients with hematologic malignancies who were undergoing anthracycline chemotherapy. The researchers conducted CMR and echocardiograms and sequenced circulating miRNAs at three different time points: before starting chemotherapy, upon completion of chemotherapy, and 6 months after completing chemotherapy.…”

Section: Cardiac Magnetic Resonance Imaging Combined With Proteomics ...mentioning

confidence: 99%

Precision Cardio-oncology: Update on Omics-Based Diagnostic Methods

Kuang,

Kong,

Yan

et al. 2024

Curr. Treat. Options in Oncol.

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Opinion statementCardio-oncology is an emerging interdisciplinary field dedicated to the early detection and treatment of adverse cardiovascular events associated with anticancer treatment, and current clinical management of anticancer-treatment-related cardiovascular toxicity (CTR-CVT) remains limited by a lack of detailed phenotypic data. However, the promise of diagnosing CTR-CVT using deep phenotyping has emerged with the development of precision medicine, particularly the use of omics-based methodologies to discover sensitive biomarkers of the disease. In the future, combining information produced by a variety of omics methodologies could expand the clinical practice of cardio-oncology. In this review, we demonstrate how omics approaches can improve our comprehension of CTR-CVT deep phenotyping, discuss the positive and negative aspects of available omics approaches for CTR-CVT diagnosis, and outline how to integrate multiple sets of omics data into individualized monitoring and treatment. This will offer a reliable technical route for lowering cardiovascular morbidity and mortality in cancer patients and survivors.

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“…With a comprehensive panel of functional assays, the authors could show that part of the cardioprotection afforded by the anti-CD47 antibody was attributable to a boosted ability of neutrophils to phagocytose apoptotic cardiomyocytes. Unlike other anti-tumor therapies, which are frequently associated with cardiotoxicity [11] , [12] , CD47-targeting approaches that augment macrophage-mediated removal of tumor cells might cause less harm to the heart and may even exert a cardioprotective effect after MI.…”

Section: Insights Into Culprit Pathways Driving Myocardial Inflammationmentioning

confidence: 99%