Prospective pilot study to explore the melatonin level in brain tumor patients undergoing radiotherapy

Panciroli, Claudia; Esteve, Anna; Muñoz-Ferrer, Aida; Abad, Jorge; Balaña, Carmen; Lucente, Giuseppe; Comas, S.; Villà, Salvador

doi:10.1007/s11325-021-02365-5

Cited by 2 publications

(10 citation statements)

References 17 publications

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“…Ten studies exclusively included high-grade glioma (HGG) samples [ 17 , 24 , 25 , 30 , 36 , 37 , 40 , 43 , 46 , 47 ], while seven exclusively included low-grade glioma (LGG) samples [ 21 , 23 , 27 , 31 , 35 , 39 , 42 ]. Seventeen studies involved mixed samples of LGG and HGG [ 14 – 16 , 19 , 20 , 22 , 26 , 28 , 29 , 32 – 34 , 38 , 39 , 41 , 44 , 45 ].…”

Section: Resultsmentioning

confidence: 99%

“…In addition to these validated sleep or symptom assessment tools, validated HRQoL assessments that included at least 1 sleep-related item were also reported, including the EORTC QLQ-C30 [ 16 , 23 – 25 , 27 , 28 , 30 , 31 , 34 , 35 , 39 – 47 ] & BN20 [ 16 , 18 , 24 , 25 , 28 , 30 , 31 , 39 , 45 , 47 ] modules, describing insomnia and drowsiness, respectively, as well as the MDASI-BT [ 14 , 15 , 39 ]. Finally, a small number of studies also included objective assessments including actigraphy [ 21 ] and polysomnography (PSG) [ 38 ].…”

Section: Resultsmentioning

confidence: 99%

“…All 34 included articles were published between 1998 and 2022, consisting of 16 cross-sectional studies [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29], 7 randomised control trials (RCT) [30][31][32][33][34][35][36], 4 quasi-experimental studies [37][38][39][40], and 7 cohort studies [41][42][43][44][45][46][47]. The results of the included articles were informed by 4,694 PBT survivors and 120 caregivers, with sample sizes ranging from 12 to 621 with an age range of 18-86 years.…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

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Prevalence and management of sleep disturbance in adults with primary brain tumours and their caregivers: a systematic review

et al. 2023

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Purpose The aims of this systematic review were to (1) examine the prevalence, severity, manifestations, and clinical associations/risk factors of sleep disturbance in primary brain tumour (PBT) survivors and their caregivers; and (2) determine whether there are any sleep-focused interventons reported in the literature pertaining to people affected by PBT. Methods This systematic review was registered with the international register for systematic reviews (PROSPERO: CRD42022299332). PubMed, EMBASE, Scopus, PsychINFO, and CINAHL were electronically searched for relevant articles reporting sleep disturbance and/or interventions for managing sleep disturbance published between September 2015 and May 2022. The search strategy included terms focusing on sleep disturbance, primary brain tumours, caregivers of PBT survivors, and interventions. Two reviewers conducted the quality appraisal (JBI Critical Appraisal Tools) independently, with results compared upon completion. Results 34 manuscripts were eligible for inclusion. Sleep disturbance was highly prevalent in PBT survivors with associations between sleep disturbance and some treatments (e.g., surgical resection, radiotherapy, corticosteroid use), as well as other prevalent symptoms (e.g., fatigue, drowsiness, stress, pain). While the current review was unable to find any sleep-targeted interventions, preliminary evidence suggests physical activity may elicit beneficial change on subjectively reported sleep disturbance in PBT survivors. Only one manuscript that discussed caregivers sleep disturbance was identified. Conclusions Sleep disturbance is a prevalent symptom experienced by PBT survivors, yet there is a distinct lack of sleep-focused interventions in this population. This includes a need for future research to include caregivers, with only one study identified. Future research exploring interventions directly focused on the management of sleep disturbance in the context of PBT is warranted.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

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Prevalence and management of sleep disturbance in adults with primary brain tumours and their caregivers: a systematic review

et al. 2023

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“…In contrast, in a prospective pilot study, Panciroli et al [ 23 ] assessed if the radiotherapy dose decreased the melatonin levels as well as the quality of life and sleep in brain tumour patients. No statistically significant differences in salivary melatonin and cortisol concentrations were observed at each timepoint, as well as according to the radiotherapy dose delivered throughout the study.…”

Section: Discussionmentioning

confidence: 99%

“… Quality assessment, including the main potential risk of bias (risk level: green—low, yellow—unspecified, red—high; quality score: green—good, yellow—intermediate, red—poor) [ 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 ]. …”

Section: Figurementioning

confidence: 99%

Salivary Melatonin Changes in Oncological Patients: A Systematic Review

2022

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Melatonin is known as a regulator of circadian sleep and waking rhythm. This hormone secreted by the pineal gland also has protective, oncostatic, and antioxidant properties. This systematic review was designed to answer the question “Is there a relationship between salivary melatonin changes and oncological diseases?”. Following the inclusion and exclusion criteria, ten studies were included, according to PRISMA statement guidelines. In all included studies, the diagnostic material was unstimulated whole saliva, in which the melatonin changes were determined by different laboratory methods. Most studies concerned changes in melatonin levels in patients with brain tumours due to a direct effect on the circadian rhythm centres. Other studies focused on disorders of melatonin secretion and its inclusion as a diagnostic marker in patients with prostate cancer and oral squamous cell carcinoma. The association between melatonin changes and sleep quality and chronotype in patients with newly diagnosed lung cancer and lymphoma survivors was also investigated. In conclusion, our systematic review may suggest trends for melatonin secretion alterations in oncological patients. However, due to the significant heterogeneity of the included reports, it is not possible to clearly determine a link between changes in salivary melatonin levels and the oncological diagnosis.

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Prospective pilot study to explore the melatonin level in brain tumor patients undergoing radiotherapy

Cited by 2 publications

References 17 publications

Prevalence and management of sleep disturbance in adults with primary brain tumours and their caregivers: a systematic review

Prevalence and management of sleep disturbance in adults with primary brain tumours and their caregivers: a systematic review

Salivary Melatonin Changes in Oncological Patients: A Systematic Review

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