Prospective randomized comparison of human oocyte freezing and vitrification: an update

Fioravanti, J.; Alegretti, J.R.; Hassun, P.A.; Motta, E.L.A.; Serafini, P.; Smith, Gary D.

doi:10.1016/j.fertnstert.2007.07.063

Cited by 4 publications

(2 citation statements)

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“…Oocyte donors are younger and do not adequately represent infertile population (7,12); hence we did not include donor oocyte (DO) cycles in the present study. We did not restrict our meta-analysis to randomized controlled trials (RCT), as there has been only one RCT with NDO, when the study was planned (13). The Institutional Review Board at New York Medical College exempted this study as de-identified existing databases were utilized for the purpose of the meta analysis.…”

Section: Methodsmentioning

confidence: 99%

Age-specific probability of live birth with oocyte cryopreservation: an individual patient data meta-analysis

Cıl

Bang

Oktay

2013

Fertility and Sterility

162

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Objective To estimate age-specific probabilities of live-birth with oocyte cryopreservation in non-donor (ND) egg cycles. Design Individual patient data (IPD) meta-analysis. Setting Assisted reproduction centers. Patients Infertile patients undergoing ND mature oocyte cryopreservation. Interventions PubMed was searched for the clinical studies on oocyte cryopreservation from January 1996 through July 2011. Randomized and non-randomized studies that used ND frozen-thawed mature oocytes with pregnancy outcomes were included. Authors of eligible studies were contacted to obtain IPD. Main outcome measures Live-birth probabilities based on age, cryopreservation method, and the number of oocytes thawed, injected, or embryos transferred. Results Original data from 10 studies including 2265 cycles from 1805 patients were obtained. Live-birth success rates declined with age regardless of the freezing technique. Despite this age-induced compromise, live-births continued to occur as late as to the ages of 42 and 44 with slowly-frozen (SF) and vitrified (VF) oocytes, respectively. Estimated probabilities of live-birth for VF oocytes were higher than those for SF. Conclusions The live-birth probabilities we calculated would enable more accurate counseling and informed decision of infertile women who consider oocyte cryopreservation. Given the success probabilities, we suggest that policy-makers should consider oocyte freezing as an integral part of prevention and treatment of infertility.

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Section: Methodsmentioning

confidence: 99%

Age-specific probability of live birth with oocyte cryopreservation: an individual patient data meta-analysis

Cıl

Bang

Oktay

2013

Fertility and Sterility

162

View full text Add to dashboard Cite

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“…Cleavage rates, day-3 embryo �uality and biochemical pregnancy rates were significantly higher in the vitrification group compared with the slow freezing one. Although statistically nonsignificant, survival, fertilization and clinical pregnancy rates were numerically in favor of vitrification [118].…”

Section: Clinical Outcome Of Oocyte Cryopreservationmentioning

confidence: 75%

Oocyte cryopreservation: a technical and clinical update

AbdelHafez

Desai

Ali

et al. 2009

Expert Review of Obstetrics & Gynecology

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The primary objective of this article is to review the most recent progress in oocyte cryopreservation using various slow-freezing and vitrification protocols. There is a significant improvement in the clinical outcomes with higher pregnancy rates following mature metaphase II oocyte cryopreservation. Moreover, some reassuring data were recently reported regarding the longterm safety of this technology. However, overall clinical pregnancy rates following oocyte cryopreservation remain less efficient than the more established practice of embryo cryopreservation. Oocyte cryopreservation is a viable alternative for fertility preservation for women at risk of premature ovarian failure due to diverse factors, such as gonadotoxic chemotherapy or radiotherapy. Currently, there are two distinct techniques for oocyte cryopreservation: slow freezing and vitrification. Oocyte vitrification is gaining popularity as the technique of choice; however, well-designed, randomized, controlled trials are still required to establish which method is the most efficient and safest for oocyte cryopreservation.

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