Prospective, Randomized Comparison of Same-Day Dose of 2 Different Bowel Cleanser for Afternoon Colonoscopy

Gweon, Tae‐Geun; Kim, Sang Woo; Noh, Yong-sun; Hwang, Seawon; Kim, Nayoung; Lee, Yoonbum; Lee, Soon-Wook; Lee, Sung Won; Lee, Jong Yul; Lim, Chul-Hyun; Kim, Hyung Hun; Kim, Jin Su; Cho, Yu Kyung; Park, Jae Myung; Lee, In Seok; Choi, Myung‐Gyu

doi:10.1097/md.0000000000000628

Cited by 27 publications

(23 citation statements)

References 21 publications

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“…Thus, it is necessary to improve the visualization of colonoscopy through better methods of intestinal cleansing 6 , 9 , 23 . The use of Aquanet EC-2000 ® (AQ) equipment increases the efficiency of retrograde bowel lavage.…”

Section: Introductionmentioning

confidence: 99%

New Bowel Preparation Technique for Colonoscopy: Clinical Trial Comparing Aquanet and Mannitol

Kaiser-Júnior

DE-Quadros

Flamini-Júnior

et al. 2018

ABCD, arq. bras. cir. dig.

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Background:Fifty-five percent of Americans aged 50-65 are submitted to colonoscopy. For over 65-year, this number increases to 64%. In Brazil, it is forecast that the population submitted to colonoscopy will grow, even though inadequate preparation is still a major problem. Aim:To analyze the quality of a new intestinal preparation technique, Aquanet EC-2000®, compared to oral Mannitol solution. Methods:This prospective longitudinal study enrolled 200 patients with indication for colonoscopy. The sample was randomly allocated to two groups of 100; one group received Aquanet EC-2000® to prepare for colonoscopy and the other Mannitol solution. The Boston scale was used to analyze the results. Results:As expected both preparations produced similar results with the bowel cleansing of the different regions of the colon being classified as Boston scale 3 (excellent) in most patients (p>0.05). Conclusion:The results of bowel preparation using Aquanet EC-2000® were similar to using Mannitol solution.

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Section: Introductionmentioning

confidence: 99%

New Bowel Preparation Technique for Colonoscopy: Clinical Trial Comparing Aquanet and Mannitol

Kaiser-Júnior

DE-Quadros

Flamini-Júnior

et al. 2018

ABCD, arq. bras. cir. dig.

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“…On the other hand, sodium picosulfate solution, a combination of magnesium oxide and citric acid, manufactured by Ferring Pharmaceuticals, Parsippany, NJ, has been demonstrated to have fewer adverse effects. It is an effective, low volume bowel cleansing product with excellent effectiveness, adequate tolerance, and less electrolyte imbalance compared to PEG [ 10 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Aquanet Bowel Cleansing Device Versus Oral Sodium Picosulfate for Pre-Endoscopy Bowel Preparation: Propensity Score Analysis for Interventional Effectiveness Evaluation

Kaiser¹,

Quadros²,

Faria³

et al. 2018

Gastroenterol Res

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BackgroundColonoscopy procedures are commonly performed and have high success rates. However, poor or inadequate bowel preparation is one of the most common reasons for a repeated or failed colonoscopy. We therefore performed an observational study followed by propensity score modeling to evaluate and compare the quality of bowel preparation with the use of Aquanet bowel cleansing devices (BCDs) versus the use of oral sodium picosulfate solution.MethodsWe performed a prospective cross-sectional study to compare the quality of pre-endoscopic bowel preparation using a BCD with oral solution. Our major outcome of interest was the quality of bowel preparation as measured through the Boston bowel preparation (BBP) scale. Our main predictor was the method of bowel preparation. The bowel was prepared using either sodium picosulfate or the BCD.ResultsA total of 314 participants were part of this study. The average age of the participants was 54 years and most of the participants were females (81%). Sodium picosulfate was associated with better scores at each segment. After propensity scoring with a 1:1 match and further adjusting for the unbalanced variable (age), we found that despite the apparent superior cleansing performance of sodium picosulfate over the BCD, the difference was not statistically significant.ConclusionThis study reinforces previous reports regarding the quality, safety and comfort of BCDs, indicating that this technique should be considered for colonoscopy preparation. In the future, randomized controlled trials should be performed to validate these preliminary findings.

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“…However, several previous studies reported no aspiration when bowel preparation was finished 2 hours before colonoscopy. [ 18 , 22 ] To investigate aspiration risk, we measured the volume of fluid in the stomach, which was <30 mL and did not differ between the 2 groups. The American Society of Anesthesiologists recommends at least 2 hours of fasting from the intake of clear liquids to before sedation.…”

Section: Discussionmentioning

confidence: 99%

“…Although willingness to reuse the cleansing regimen was lower than reported in previous studies, [ 15 , 22 ] in this study we used 4L PEG, which was related to patient inconvenience because of the large volume. [ 18 ] Future studies should compare the safety and tolerability of same-day dosing with PEG with those of split-dose regimen.…”

Section: Discussionmentioning

confidence: 99%

“…The composite safety profile included vital signs, laboratory test results, and questionnaire findings. [ 18 ] Vital signs and laboratory parameters included in the health check-up program were checked on the day of colonoscopy. Serum hemoglobin concentration, hematocrit, white blood cell (WBC) count, and concentrations of glucose, sodium, potassium, chloride, calcium, phosphorus, creatinine, and blood urea nitrogen (BUN) were checked.…”

Section: Methodsmentioning

confidence: 99%

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Validation of same-day bowel preparation regimen using 4L polyethylene glycol

Huh

Gweon²,

Seo³

et al. 2018

Medicine

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A split-dose regimen is the recommended method of bowel preparation for colonoscopy. However, for colonoscopy performed in the afternoon, same-day preparation is recommended rather than a split-dose regimen. No study has compared the efficacy of same-day bowel-cleansing for morning colonoscopy (MC) and afternoon colonoscopy (AC). The aims of this study were to evaluate the bowel-cleansing efficacy, adverse events, and patient tolerability of same-day bowel preparation for colonoscopy using 4L polyethylene glycol (PEG).The medical records of consecutive patients who underwent colonoscopy at our healthcare center over 3 months were retrospectively reviewed. Colonoscopy was performed between 10:00 and 16:00. Study subjects were assigned to the MC or AC group according to their colonoscopy start time (MC group, before 12:00; AC group, after 12:00). Study subjects were instructed to drink 500-mL PEG every 15 minutes. In the MC group, bowel cleansing was started at 05:00 and finished at 07:00. For the AC group, 2L PEG was consumed from 07:00, and the remaining 2L PEG was started 3 hours before colonoscopy. The composite safety profile included vital signs, laboratory test results, and questionnaire findings. Laboratory testing of subjects and completion of the questionnaire were performed before colonoscopy. The questionnaire asked about adverse events and tolerability of the bowel cleansing regimen. Bowel-cleansing efficacy was assessed using the Boston bowel preparation scale (BBPS). Bowel-cleansing efficacy, tolerability, and safety profile were compared between the 2 groups.Two hundred and ninety-one subjects were included (MC group, 169; AC group, 122).The BBPS did not differ between the 2 groups (7.3 ± 0.8 vs. 7.3 ± 0.8, P = .68). There were no instances of electrolyte imbalance or hemodynamic instability in either group. The tolerability of the bowel-cleansing regimen did not differ between the 2 groups (P = .59).The bowel-cleansing efficacy, safety profile, and patient tolerability of MC and AC were comparable. A same-day dose of 4L PEG is a feasible bowel preparation method.

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Prospective, Randomized Comparison of Same-Day Dose of 2 Different Bowel Cleanser for Afternoon Colonoscopy

Cited by 27 publications

References 21 publications

New Bowel Preparation Technique for Colonoscopy: Clinical Trial Comparing Aquanet and Mannitol

New Bowel Preparation Technique for Colonoscopy: Clinical Trial Comparing Aquanet and Mannitol

Aquanet Bowel Cleansing Device Versus Oral Sodium Picosulfate for Pre-Endoscopy Bowel Preparation: Propensity Score Analysis for Interventional Effectiveness Evaluation

Validation of same-day bowel preparation regimen using 4L polyethylene glycol

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