Prospective, randomized trial examining the role of gentamycin-containing collagen sponge in the reduction of postoperative morbidity in rectal cancer patients: early results and surprising outcome at 3-year follow-up

Abstract

The use of the gentamycin collagen sponge after excision of rectal cancer is safe and reduces the rate of early postoperative complications. The reasons for the lower rate of distant metastasis in the GRM(+) group are not clear, but the patients enjoy significant survival benefits.

Randomized clinical trial of local gentamicin–collagen treatment in advancement flap repair for anal fistula

“…Local application of gentamicin-collagen has been used both to prevent and treat surgical wound infection 12 -14 . This treatment has been demonstrated to improve perineal wound healing after abdominoperineal excision of rectal cancer 15 and to reduce postoperative complications after rectal cancer surgery 16 . The primary aim of the present study was to evaluate whether local antibiotic treatment with gentamicin-collagen improves healing after endoanal advancement flap repair for anal fistula.…”

Gentamicin/Collagen Sponge Use May Reduce the Risk of Surgical Site Infections for Patients Undergoing Cardiac Operations: A Meta-Analysis

“…Identical systemic prophylactic antimicrobial regimens were given to both the intervention and control groups in eight studies [6][7][8][9][10]12,13,16]. One study used different antimicrobial regimens for the intervention and control groups [15].…”

“…Twenty-two articles were potentially relevant and were reviewed in detail. Of these, 13 were included in the final analysis [5][6][7][8][9][10][11][12][13][14][15][16][17].…”

“…Despite the routine use of systemic prophylactic antimicrobial agents, SSIs continue to be associated with substantial morbidity following various types of surgery. Alternative methods of antimicrobial prophylaxis have therefore been studied, including the application of antimicrobial agents locally within a surgical incision [2][3][4].A number of studies have examined the efficacy of implanting gentamicin/collagen sponges in surgical incisions to reduce the risk of SSI [2,[5][6][7][8][9][10][11][12][13][14][15][16][17]. Currently, this method of delivering antimicrobial agents is approved in 54 countries and these sponges have been used in more than two million patients; however, they are not approved for use in the United States [18].…”

Gentamicin–Collagen Sponge for Infection Prophylaxis in Colorectal Surgery

“…Several studies suggest that the sponge may be effective in the prevention and treatment of infections after general surgery. 6,13,14 In a single-center, randomized trial, patients who underwent colorectal surgery and received a sponge had a 70% decrease in surgical-site infection, as compared with those who did not receive a sponge. 6 The current phase 3 trial was designed to confirm these promising data and support regulatory approval in the United States.…”