Prospective study of 424 cases of <i>Staphylococcus aureus</i> bacteraemia: determination of factors affecting incidence and mortality

Hill, Philip C.; Birch, M.; Chambers, Susan M.; Drinković, Dragana; Rb, Ellis-Pegler; Everts, Richard J.; Murdoch, David R.; Pottumarthy, Sudha; Roberts, Sally; Swager, C.; Taylor, Susan; Thomas, Mark G.; Wong, CW; Morris, Arthur J.

doi:10.1111/j.1444-0903.2001.00029.x

Cited by 161 publications

(68 citation statements)

References 24 publications

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“…The vast majority of S. aureus strains in New Zealand are methicillin susceptible (MSSA); the prevalence of methicillinresistant S. aureus (MRSA) remains low, at about 5% (12). New Zealand has a high incidence of S. aureus disease; the incidence of S. aureus bacteremia in the late 1990s was 41 cases per 100,000 adults per year (12).…”

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confidence: 99%

Incidence, Risk Factors, and Outcomes of Panton-Valentine Leukocidin-Positive Methicillin-Susceptible Staphylococcus aureus Infections in Auckland, New Zealand

et al. 2010

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Incidence, Risk Factors, and Outcomes of Panton-Valentine Leukocidin-Positive Methicillin-Susceptible Staphylococcus aureus Infections in Auckland, New Zealand

et al. 2010

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“…In a large study with 424 cases of S. aureus bacteremia performed in New Zealand [20] , older age than 60 years, feminine sex, diabetes, immunosuppression and lung as a source of bacteremia were identified as risk factors for mortality.…”

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confidence: 99%

Risk Factors for Bacteremia and Predictors of Mortality of Patients with Bloodstream Infection with Methicillin-Resistant Staphylococcus aureus

Bakowski¹,

Wey²,

Medeiros³

2008

American J. of Infectious Diseases

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Abstract:The objective of this study was to evaluate the incidence of infection and the risk factors associated to bacteraemia and mortality due to Methicillin-Resistant Staphylococcus Aureus (MRSA). This cohort study, conducted from August 2004 through November 2005, involved 60 consecutively identified patients with bloodstream MRSA infection. The control group included 240 non-infected patients, randomly selected and hospitalized on the day, or immediately after, results of blood culture of case patients were available. A case-control (1:4) study was conducted for evaluation of risk factors for bacteraemia and death. The incidence of infection was 1.99/1000 admissions. Mortality rates were 30% among patients and 5.38% among controls, with an attributed death rate of 24.6%. Multivariate analysis indicated the following risk factors for bacteraemia: severity predictors McCabe = 1, ASA>2 or APACHE II>10 (OR: 4.1; 95% CI: 1.8 -9.4) and use of central venous catheter (OR: 7.3; 95% CI: 2.4-22.2). University analysis showed as risk factors for mortality: age (OR: 1.08; 95% CI: 1.03-1.12), severity predictors McCabe = 1, ASA > 2 or APACHE II > 10 (OR: 9.13; 95% CI: 2.57-32.35), use of mechanical ventilation (OR: 10.32; 95% CI: 1.78-59.51) and use of corticoids (OR: 9.96; 95% CI: 2.69-36.78). Our results when investigating risk factors for bacteremia and mortality due to MRSA showed moderate influence of control group selection, in comparison to studies in which methicillinsensitive S. aureus infection is used as control.

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“…En los diversos estudios realizados se han identificado múltiples factores relacionados con aumento de la morbimortalidad, asociada con la bacteriemia por S. aureus (12,15,17,18,30,54,55). Se han identificado factores del huésped que se asocian con un desenlace adverso, como edad mayor de 60 años e inicio de la bacteriemia en la comunidad (56)(57)(58)(59)(60).…”

Section: Factores De Riesgo Y Pronósticosunclassified

“…Se han identificado factores del huésped que se asocian con un desenlace adverso, como edad mayor de 60 años e inicio de la bacteriemia en la comunidad (56)(57)(58)(59)(60). En este sentido también se han encontrado elementos de la anamnesis o del examen físico, como la presencia de cuerpos extraños o prótesis (52), la incapacidad de identificar el foco de la bacteriemia (12,51,59,61), la morbilidad asociada grave y previa (52,56,59,62), la presencia de lesiones vasculares cutáneas (16), las metástasis infecciosas y la presencia de choque séptico al ingreso (6).…”

Section: Factores De Riesgo Y Pronósticosunclassified

“…En los Estados Unidos, entre 1980 y 1990, se incrementaron los casos de bacteriemia por S. aureus en 283% en hospitales no universitarios y, en 176%, en hospitales universitarios (7,12,13). Según el lugar de adquisición de la bacteriemia por S. aureus se encuentra que 17% a 49% se originan en la comunidad, 51% a 83% son hospitalarias y 30% a 38% están asociadas con trabajadores de la salud (ver más adelante) (13)(14)(15)(16)(17).…”

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Enfoque terapéutico de la bacteriemia por Staphylococcus aureus

et al. 2007

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Staphylococcus aureus es un patógeno importante que causa cerca de 11% a 33% de las bacteriemias hospitalarias y un porcentaje importante de las adquiridas en la comunidad, con una tasa de complicaciones cercana a 50%. En la siguiente revisión se destaca la epidemiología de la bacteriemia por S. aureus, con especial referencia a la situación de este patógeno en Colombia, la frecuencia y los mecanismos de resistencia a los medicamentos más frecuentemente usados en este contexto, y se discuten los elementos semiológicos, clínicos y de laboratorio que influyen en el enfoque diagnóstico y terapéutico de los pacientes con bacteriemia por este microorganismo.Palabras clave: Staphylococcus aureus/patogenicidad, bacteriemia/terapia, bacteriemia/ epidemiología, agentes antibacterianos/uso terapéutico. Therapeutic approach to Staphylococcus aureus bacteremiaStaphylococcus aureus is an important human pathogen, responsible for 11-33% of the bacteremias acquired in the hospital setting and nearly 50% of those acquired in the community at large. The epidemiology of S. aureus bacteremia is discussed, with an special emphasis on the situation in Colombia and the resistance mechanisms against the major drug groups used for the treatment. The clinical keys and laboratory support for the appropriate clinical approaches are presented together with the therapeutic strategies for the treatment of patients with S. aureus bacteremia.

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Prospective study of 424 cases of Staphylococcus aureus bacteraemia: determination of factors affecting incidence and mortality

Abstract: Staphylococcus aureus bacteraemia is more likely to occur in certain ethnic groups, while mortality is associated with other identifiable risk factors and continues to be high. Intravenous catheters remain the most common and most preventable cause of SAB.

Cited by 161 publications

References 24 publications

Incidence, Risk Factors, and Outcomes of Panton-Valentine Leukocidin-Positive Methicillin-Susceptible Staphylococcus aureus Infections in Auckland, New Zealand

Incidence, Risk Factors, and Outcomes of Panton-Valentine Leukocidin-Positive Methicillin-Susceptible Staphylococcus aureus Infections in Auckland, New Zealand

Risk Factors for Bacteremia and Predictors of Mortality of Patients with Bloodstream Infection with Methicillin-Resistant Staphylococcus aureus

Enfoque terapéutico de la bacteriemia por Staphylococcus aureus

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