Prospective Study of Correlation between Carotid Intimal Medial Thickness and Non Alcoholic Fatty Liver Disease Along with Its Grades

Abstract

Abstract:This study was performed to study correlation between CIMT and NAFLD. This was hospital-based prospective study conducted at the Department of Medicine, Hamidia Hospital and Gandhi Medical College, Bhopal during period of May 2014 to Nov 2014. 100 patients with ultrasonographically proven NAFLD patients from OPD and IPD(45 males and 55 females)AND 100 patients (47 males 53 males) without NAFLD on ultrasonography abdomen were studied. The grade of NAFLD was also taken into correlation for CIMT thickness. After obtaining informed written consent, the general information of patients was recorded on a proforma. After overnight fasting, blood samples was drawn for complete hemogram, blood urea , serum creatinine, lipid profile and serum Mg. Carotid intima media thickness (CIMT) was measured by B mode ultrasound using a 7.5MHz transducer. Descriptive and inferential statistical analyses were performed using SPSS version 20.0.the study shows that average age in NAFLD group was 77.7yrs and was higher than in control group that was 56.33yrs .The study shows that mean BMI is higher in subjects with NAFLD in both males and females as compared to that in non NAFLD group. The study shows that mean Waist/hip ratio is higher in subjects with NAFLD in both males and females as compared to that in non NAFLD group. Serum SGOT and SGPT levels were found to be significantly higher in subjects with NAFLD as compared to that in non NAFLD group.The study shows that CIMT on both sides were higher on NAFLD group as compared to non NAFLD group. We concluded that patients with NAFLD have significant positive correlation, and CIMT (significantly correlated positively with grades of NAFLD as well).It is suggested that since NAFLD along with the grades is associated with inflammation of liver, metabolicsyndrome, increased CIMT(which is a proven marker for atherosclerosis an d a predictor of CAD and CVA).so now with further research and analysis NAFLD could also be considered as a marker for atherosclerosis and as extended spectrum of metabolic syndrome.