Prospective study of peritoneal recurrence after curative surgery for gastric cancer

Roviello, Franco; Marrelli, Daniele; Manzoni, Giovanni De; Morgagni, Paolo; Leo, Alberto Di; Saragoni, Luca; Stefano, Alfonso De

doi:10.1002/bjs.4164

Cited by 203 publications

(149 citation statements)

References 28 publications

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“…The finding of univariate analysis regarding to age at diagnosis is in line with another research that showed significant correlation between age at diagnosis and recurrent GC (Roviello et al, 2003;Lai et al, 2009). Thus, it showed older age was significantly related to the progress of GC recurrent.…”

Section: 2639 Gastric Cancer Recurrence and Associated Factors In Iransupporting

confidence: 89%

Prediction of Time to Recurrence and Influencing Factors for Gastric Cancer in Iran

Roshanaei

Ghannad²,

Safari³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Background: The patterns of gastric cancer recurrence vary across societies. We designed the current study in an attempt to evaluate and reveal the outbreak of the recurrence patterns of gastric cancer and also prediction of time to recurrence and its effected factors in Iran. Conclusions: We found that pathologic stage, tumor grade and tumor site significantly affect on the recurrence of GC which has a high positive prognostic value and might be functional for better follow-up and selecting the patients at risk. We also showed time to recurrence to be an important factor for follow-up of patients.

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Section: 2639 Gastric Cancer Recurrence and Associated Factors In Iransupporting

confidence: 89%

Prediction of Time to Recurrence and Influencing Factors for Gastric Cancer in Iran

Roshanaei

Ghannad²,

Safari³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…9,15 In the randomized Taiwan trial, the number of patients who relapsed beyond 3 years after extended dissection was limited, but several relapses occurred over time in the D1 group making overall and disease-free survival curves of the two groups to diverge more clearly after 36 months. 4 This figure was also evident in the final results of the randomized Dutch trial in pN1 and pN2 subgroups 16 and, similarly, in our experience.…”

Section: Extent Of Lymphadenectomy and Tumour Recurrencementioning

confidence: 99%

Super-extended (D3) lymphadenectomy in advanced gastric cancer

Roviello¹,

Pedrazzani²,

Marrelli³

et al. 2010

European Journal of Surgical Oncology (EJSO)

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Purpose: To analyze our experience with D3 lymphadenectomy in the treatment of advanced GC with specific reference to post-operative morbidity and mortality, incidence of para-aortic node (PAN) metastases, and long-term prognosis.Methods: Short-and long-term results of D3 lymphadenectomy were analyzed in 286 patients with advanced GC.Results: PAN metastases were demonstrated in 37 patients. PAN involvement was significantly higher in upper third tumours (29%) compared to middle and lower third (7%; P < 0.001). Eighty patients developed postoperative complications, being pulmonary disorders (6%), abdominal abscesses (4.5%) and pancreatic fistulas (3%) the most frequently observed. In-hospital mortality was 2%. Overall 5-year survival rate for R0 pT2-4 patients was 52%. When considering survival in relation to nodal involvement, both pN3 and non-regional lymph node metastases (M1a) patients showed a chance of long-term survival: 5-year survival was 31% for pN3 and 17% for M1a cases. Furthermore, the 5-year survival rate was remarkably high (about 60%) even in pN2 and pN3 subsets when no serosal invasion (pT2) was demonstrated.Conclusions: D3 lymphadenectomy should be considered in specialized centers for curative surgery of advanced GC, especially for upper third tumours, providing that an acceptable morbidity and no increase in mortality can be offered.

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“…PC accounts for 35% of synchronous metastasis and is the sole site of metastasis in 9% of cases [3]. In the recurrent setting, peritoneal carcinomatosis can occur in up to 46% of cases and as the only site in up to 40% of cases [3,[43][44][45][46][47][48].…”

Section: Discussionmentioning

confidence: 99%

Survival outcomes after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal carcinomatosis from gastric cancer: a systematic review

Chia

Seshadri

Képénékian³

et al. 2016

Pleura and Peritoneum

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Background: The current treatment of choice for peritoneal carcinomatosis from gastric cancer is systemic chemotherapy. Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) is a new aggressive form of loco-regional treatment that is currently being used in pseudomyxoma peritoneii, peritoneal mesothelioma and peritoneal carcinomatosis from colorectal cancer. It is still under investigation for its use in gastric cancer. Methods: The literature between 1970 and 2016 was surveyed systematically through a review of published studies on the treatment outcomes of CRS and HIPEC for peritoneal carcinomatosis from gastric cancer. Results: Seventeen studies were included in this review. The median survival for all patients ranged from 6.6 to 15.8 months. The 5-years overall survival ranged from 6 to 31%. For patients with complete cytoreduction, the median survival was 11.2 to 43.4 months and the 5-years overall survival was 13 % to 23%. Important prognostic factors were found to be a low peritoneal carcarcinomatosis index (PCI) score and the completeness of cytoreduction.

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Prospective study of peritoneal recurrence after curative surgery for gastric cancer

Abstract: Radical surgery offers a low probability of cure in patients with diffuse-mixed type of gastric cancer and involvement of the serosa, due to a high risk of peritoneal recurrence. These patients might benefit from adjuvant therapies to prevent peritoneal carcinomatosis.

Cited by 203 publications

References 28 publications

Prediction of Time to Recurrence and Influencing Factors for Gastric Cancer in Iran

Prediction of Time to Recurrence and Influencing Factors for Gastric Cancer in Iran

Super-extended (D3) lymphadenectomy in advanced gastric cancer

Survival outcomes after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal carcinomatosis from gastric cancer: a systematic review

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