Prospective study on burns treated with Integra®, a cellulose sponge and split thickness skin graft

Protease-sensitive atelocollagen hydrogels promote healing in a diabetic wound model

“…4,5 In contrast to skin substitutes, 6 wound dressings are temporarily applied to the wound bed, in order to ensure a defined environment in terms of moisture (to minimise the risk of tissue maceration) and exudate management (to retain growth factors, MMPs and specific cells key to healing). 7,8 Furthermore, an ideal wound dressing should (i) provide thermal insulation and oxygen exchange; (ii) protect damaged tissue from secondary infections and bacterial contamination; (iii) display low adherence in situ to enable complete dressing removal without debris formation and integration with the host tissue; (iv) control activity of up-regulated MMPs, such as MMP-9, 9,10,11,12,13,14,15,16,17 in order to promote wound healing; (v) not induce any toxic response to tissue microenvironment.…”

Efficacy of dermal substitute on deep dermal to full thickness burn injury: a systematic review

“…All the studies included used DRTs on deep dermal to full thickness burn injuries. Burn wounds that were considered clinically to be deep dermal to full thickness for were treated acutely with early excision and grafted within 7 days of the injury except for the study by Peck et al ., where the burn injuries were treated with sequential excision within 2 weeks of injury . After early excision, the wounds were immediately covered with either dermal substitute or STSG.…”

“…Six of the seven studies included adults while two of the seven studies, Heimbach et al . and Branski et al ., included paediatrics in their study population . Peck et al .…”

“…( n = 85). The rest of the studies had relatively small sample sizes ranging from seven to 20 . Six of the seven studies were performed on burn injures with TBSA >25% .…”

“…Six of the seven studies were performed on burn injures with TBSA >25% . Five of the seven studies had long‐term follow‐up reaching to at least 12 months or more . The study by Peck et al .…”