Prospective study on the cytological aspects of the nasal respiratory epithelium in premenopausal women taking 30 mcg ethinylestradiol and 3 mg drospirenone oral contraceptive

Caruso, Salvatore; Grillo, Calogero; Agnello, Carmela; Mari, Lucia Di; Cianci, Antonio

doi:10.1016/j.contraception.2007.12.010

Cited by 8 publications

(5 citation statements)

References 28 publications

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“…Since this hypothesis, several authors researched the relationship between the hormone level and nasal phenotypic modifications. Some authors observed the same cytological changes between nasal mucosa and vaginal epithelium according to the menstrual cycle (Armengot, Basterra, & Marco, 1990; Caruso et al, 2001; Caruso et al, 2006; Caruso, Serra, Grillo, Agnello, et al, 2008; Henderson, 1956; Nappi et al, 2003; Navarrete‐Palacios et al, 2003; Philpott, Conboy, Al‐Azzawi, & Murty, 2004; Toppozada et al, 1981, 1984). They also observed some characteristics in nasal mucosa related to high levels of estrogen such as: vasodilation, enhancement of the vascularization, and increase of glandular secretion.…”

Section: Estrogen and Its Impact In Nasal Mucosamentioning

confidence: 84%

“…Caruso et al (Caruso, Serra, Grillo, Agnello, et al, 2008; Caruso, Serro, Grillo, Maiolino, et al, 2008) published two studies about the relationship between female hormonal cycle and nasal mucosa. The first one observed cytological aspects of the nasal epithelium in women before menopause using pills with 30 μg of ethinylestradiol and one with postmenopausal women receiving 1 mg ethinyl estradiol.…”

Section: Introductionmentioning

confidence: 99%

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Estrogen receptors and their roles in the immune and respiratory systems

Millas

Barros²

2021

The Anatomical Record

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Estrogen is an important hormone for health in both genders. It is indispensable to glucose homeostasis, immune robustness, bone health, cardiovascular health, and neural functions. The main way that estrogen acts in the cells is through estrogen receptors (ERs). The presence of specific estrogen receptors is required for estrogen to have its characteristic ubiquitous action in almost all tissues. Estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ) are the major isoforms of estrogen that are highly specific in humans and enable selective hormonal actions in different tissues. This article reviews some of the observed estrogen actions and effects in different tissues and cells through these specific receptors. This ubiquitous, almost ordinary hormone may reveal itself as a significant factor that helped us to better understand the complexity of the human immune system response against respiratory infections, including the COVID-19, and especially in the current state of this painful pandemic.

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Section: Estrogen and Its Impact In Nasal Mucosamentioning

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Estrogen receptors and their roles in the immune and respiratory systems

Millas

Barros²

2021

The Anatomical Record

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“…It seems to have a direct activity on the neuronal conduction time into the audiological system [16]. Another study done in this regard was conducted to determine the effects of the monophasic oral contraceptive containing 30 mcg ethinylestradiol and 3 mg drospirenone on the nasal respiratory epithelium in premenopausal women, which showed that maturation index of the nasal respiratory epithelium seems to depend on the variation of the ovarian steroids during the menstrual cycle and on the iatrogenic effects of oral contraception [17]. …”

Section: Discussionmentioning

confidence: 99%

Hearing Performance in the Follicular-Luteal Phase of the Menstrual Cycle

Emami

Gohari

Ramezani

et al. 2018

International Journal of Otolaryngology

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Introduction Estrogen has a protective role on auditory function. It may have an excitatory action on auditory nerve fibers and can have a neuroprotective effect. Progesterone has a mainly inhibitory action on the central nervous system, which may balance the mainly excitatory action of estrogen. Objective To determine changes in hearing performance with pure tone audiometry (PTA), tympanometry, distortion product otoacoustic emissions (DPOAEs), and auditory brainstem responses (ABR) as hormonal changes occur from follicular to luteal phase. Materials and Methods Twenty healthy female volunteers (age 19 ± 30 years) with normal menstrual cycle and without any hearing problems are included in this case-control study. Hearing evaluation was performed on the 13th day of the menstrual cycle (follicular phase) and then on the 22nd day (luteal phase). Results All of the participants had normal results in follicular phase. In luteal phase, four cases showed abnormalities as follows: reduced hearing thresholds 250 Hz (mean= 15 dBHL), increased amplitudes of DPOAE (mean= 3 dBspl), decreased middle ear pressure (mean= -110 dapa), and delayed ABR interpeak latencies (mean of IPLs I-III= 0.4 and mean of IPLs III-V= 0.6 ms). Conclusions In some women, changing of ovarian hormones may induce fluctuating hearing and increased progesterone in luteal phase can lead to abnormal outcomes in auditory function. However, elevated estrogen modifies its consequences in follicular phase.

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“…The study of experimental animals and livestock stimulated its development [15,16] . Knowledge of vaginal epithelia not being the only target structure in the action of steroid hormones is likewise permanently developed [17][18][19] .…”

Section: Discussionmentioning

confidence: 99%

Contribution of Hormonal Cytology in Girls and Adolescents to Reproductive Health: A Traditional Technique Monitoring Recent Problems

Dušková¹,

Goldová²,

Matiášková³

et al. 2017

Acta Cytologica

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Objective: To study the contribution of hormonal cytology in contemporary disturbances of fertility. Design: Over a 10-year period (2006-2015), 6,688 vaginal fornix cytologies of 2,350 patients were investigated. For a more detailed analysis, a 3-year period from 2013 to 2015 was chosen. Four hundred and fifty-two patientswere investigated, many of them several times and for a period longer than the 3 years analyzed. Results: The main disorders examined and treated via a gentle hormonal medication support and life style corrections by a pediatric gynecologist were: pubertas praecox - thelarche praecox and early menarche; dysfunctional juvenile metrorrhagia; central and peripheral endocrine disorders; eating disorders - anorexia mentalis and bulimia; obesity; excessive sport activities; autoimmune disorders, and others. Normalization of the menstrual cycle was achieved while monitoring progress with a series of hormonal cytologies in a majority of patients. Conclusions: Hormonal cytology is a non-invasive and economical method, illustrating the direct effect of steroid on target cells. It contributes to reproductive health support by: (a) indicating the possible need and type of steroid therapy; (b) monitoring the normalization of cycle disturbances; (c) ruling out or indicating the need for more detailed steroid metabolism investigation. Thus, it represents a basic but valuable means of examination in child and adolescent gynecology.

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Prospective study on the cytological aspects of the nasal respiratory epithelium in premenopausal women taking 30 mcg ethinylestradiol and 3 mg drospirenone oral contraceptive

Cited by 8 publications

References 28 publications

Estrogen receptors and their roles in the immune and respiratory systems

Estrogen receptors and their roles in the immune and respiratory systems

Hearing Performance in the Follicular-Luteal Phase of the Menstrual Cycle

Contribution of Hormonal Cytology in Girls and Adolescents to Reproductive Health: A Traditional Technique Monitoring Recent Problems

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