Prospective study relating genotype profiles with race performance in racing pigeons

Kolvenbag, Geert; Scott, Mark; Kloet, Arne de; Kloet, Ed de

doi:10.1007/s13353-022-00697-w

Cited by 3 publications

(6 citation statements)

References 8 publications

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“…While there are limitations with a retrospective analysis of genotype relating to race performance, in our report such analysis was used to test the hypothesis generated from our large prospective study [7]. It is very encouraging to see that our results indicate that pigeons in our family of birds with the genotype DRD4 CCCT and F-KER TT seem to be very likely consistent Top10% race performers over all distances including the final longest distance of around 325-400 miles.…”

Section: Discussionmentioning

confidence: 70%

“…In the quest to identify genotypes relating to race performance in racing pigeons multiple studies reported about the effect of variability in a single gene [1][2][3][4][5][6][7][8][9][10][11][12]. Most frequently reported genes are LDHA, DRD4, F-KER, and more recently CRY1.…”

Section: Introductionmentioning

confidence: 99%

“…Variability in these genes could potentially impact race performance. The first genotype profile based on a multivariate analysis involving genotype analyses of LDHA, DRD4, F-KER, and MSTN was reported by Kolvenbag et al [7].…”

Section: Introductionmentioning

confidence: 99%

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Consistent Race Performance in Racing Pigeons: A Case Report Confirming a Favorable Genetic Profile

Kolvenbag

2024

Corpus J Vet Dairy Sci

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A recent multivariate analysis showed that racing pigeons had a better race performance based on DRD4 and F-KER genotypes that were independently statistically significant and those racing pigeons with both DRD4 CCCT and F-KER TT had the lowest race coefficient, i.e. the best race performance. This result indicated that 50% birds with this genotype were consistently in the top 10% in the race results. To date, this is the first multigene genotype reported relating to race performance. In 2023, a consistently performing racing pigeon scored in or around the top 10% in all races of a 5 race series ranging from 100 mile to 350 miles. Retrospectively, this bird was shown to have indeed DRD4 CCCT and F-KER TT. Another bird while distantly family related, showed top performance only in the final long distance race but lacked consistency throughout the race series; this bird not have the consistency genotype profile. We pose the hypothesis that birds with both DRD4 CCCT and F-KER TT are more likely to score consistently in the Top 10% in a race series than birds without. This would need to be confirmed in a larger study in particular including Ace Champion birds with consistent top 10% race performance.

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Section: Discussionmentioning

confidence: 70%

Section: Introductionmentioning

confidence: 99%

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Consistent Race Performance in Racing Pigeons: A Case Report Confirming a Favorable Genetic Profile

Kolvenbag

2024

Corpus J Vet Dairy Sci

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“…Previous studies have shown that mRNA expression of MSTN is significantly higher in breast muscle than in other tissues and increases with at 1-28 days (Liu et al, The MSTN gene exon 3 c.C861T (p.T287T) synonymous mutation has been observed in the meat, carrier and ornamental pigeon populations (Dybus et al, 2013). The T allele frequency is higher in the meat pigeon population, and statistical correlation between the mutation and competition ability cannot be obtained in the carrier pigeon population owing to the low gene frequency of mutant TT (Dybus et al, 2018;Kolvenbag et al, 2022). However, there is a lack of correlation validation between MSTN p.T287T and MM phenotype data.…”

Section: Discussionmentioning

confidence: 99%

Genome‐wide association study of growth traits and validation of key mutations (MSTN c.C861T) associated with the muscle mass of meat pigeons

Hou,

Wang,

et al. 2023

Animal Genetics

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Selective breeding of meat pigeons is primarily based on growth traits, especially muscle mass (MM). Identification of functional genes and molecular markers of growth and slaughter traits through a genome‐wide association study (GWAS) will help to elucidate the underlying molecular mechanisms and provide a theoretical basis for the selective breeding of meat pigeons. The phenotypic data of body weight (BW) and body size (BS) of 556 meat pigeons at 52 and 80 weeks of age were collected. In total, 160 434 high‐quality single nucleotide polymorphism sites were obtained by restriction site‐associated DNA sequencing. The GWAS analysis revealed that MSTN, IGF2BP3 and NCAPG/LCORL were important candidate genes affecting the growth traits of meat pigeons. IGF2BP3 and NCAPG/LCORL were highly correlated to BW and BS, which are related to overall growth and development, while MSTN was associated with pectoral thickness and BW. Phenotypic association validation with the use of two meat pigeon populations found that the MSTN mutation c.C861T determines the MM. These results provide new insights into the genetic mechanisms underlying phenotypic variations of growth traits and MM in commercial meat pigeons. The identified markers and genes provide a theoretical basis for the selective breeding of meat pigeons.

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“…In pigeon research, a candidate gene may be proposed, and, using homing and non-homing pigeons ( Columba livia domestica ) and racing records, potential associations between racing performance and DNA polymorphisms can be uncovered. In the group of potential genetic markers of pigeons’ racing performance are the LDHA gene [ 30 , 31 , 32 , 33 ], DRD4 [ 34 , 35 ], FCBP ( F-KER ) [ 35 , 36 , 37 ], CRY1 [ 38 ] and MSTN [ 39 ]. In whole genome analyses of 95 pigeons of various breeds, polymorphisms in the GSR and LRP8 genes have been identified as a potential markers of racing performance in homing pigeons [ 40 , 41 ].…”

Section: Introductionmentioning

confidence: 99%

Calcium/Calmodulin-Dependent Serine Protein Kinase (CASK) Gene Polymorphisms in Pigeons

Dybus,

Kulig,

Grzesiak

et al. 2023

Animals

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Calcium/calmodulin-dependent serine protein kinase (CASK) is an multidomain protein involved in tissue development and cell signalling. In skeletal muscle, it is involved in the development of neuromuscular junctions. The participation of a pigeon in racing is a great physical effort that causes many changes in the skeletal muscles. Thus, the purpose of the study was to detect the nucleotide sequence variability in the calcium/calmodulin-dependent serine kinase (CASK) gene in domestic pigeons (Columba livia domestica) and assess the potential impact of DNA polymorphisms on the flight performance of pigeons. The research included a total of 517 individuals. DNA was extracted from the blood. A DNA fragment from nucleotides 8689 to 9049 of the CASK (NW_004973256.1 sequence) of six unrelated pigeons were sequenced. One of the detected polymorphic sites (g.8893G > A), located a very close to the start codon, was selected for genotyping in all individuals. The association studies included a total of 311 young homing pigeons that participated in racing competitions. The homing pigeons showed higher frequencies of the AA genotype than non-homing ones (p < 0.05). In rock pigeons only the GG genotype was found. Further research could confirm the functionality of the CASK g.8893G > A SNP in shaping the racing phenotype of pigeons, and the AA genotype could be useful as a selection criterion in pigeon breeding.

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Prospective study relating genotype profiles with race performance in racing pigeons

Cited by 3 publications

References 8 publications

Consistent Race Performance in Racing Pigeons: A Case Report Confirming a Favorable Genetic Profile

Consistent Race Performance in Racing Pigeons: A Case Report Confirming a Favorable Genetic Profile

Genome‐wide association study of growth traits and validation of key mutations (MSTN c.C861T) associated with the muscle mass of meat pigeons

Calcium/Calmodulin-Dependent Serine Protein Kinase (CASK) Gene Polymorphisms in Pigeons

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